Imperial College London
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DrEhsanGhorani

Faculty of Medicine, Department of Surgery & Cancer

Clinical Senior Lecturer in Medical Oncology
 
 
 
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Contact

 

e.ghorani

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Porter:2021:10.1016/j.gore.2021.100782,
author = {Porter, A and Barcelon, JM and Budker, RL and Marsh, L and Moriarty, JM and Aguiar, X and Rao, J and Ghorani, E and Kaur, B and Maher, G and Seckl, MJ and Konecny, GE and Cohen, JG},
doi = {10.1016/j.gore.2021.100782},
journal = {Gynecologic Oncology Reports},
pages = {1--4},
title = {Treatment of metastatic placental site trophoblastic tumor with surgery, chemotherapy, immunotherapy and coil embolization of multiple pulmonary arteriovenous fistulate},
url = {http://dx.doi.org/10.1016/j.gore.2021.100782},
volume = {36},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Placental Site Trophoblastic Tumor (PSTT) is a rare malignancy that often presents with extensive disease and can be resistant to traditional treatments. We present the case of a woman with stage IV PSTT who was initially managed with neoadjuvant chemotherapy followed by tumor debulking. Adjuvant therapy was guided by further pathologic analysis that revealed high levels of staining for PD-L1 as well as the presence of tumor infiltrating lymphocytes (TILs). Subsequently, the patient was treated with traditional chemotherapy with the EP/EMA regimen with the addition of pembrolizumab. The patient’s treatment course was complicated by the development of pulmonary arteriovenous malformations, autoimmune thyroiditis thought to be secondary to immunotherapy, and significant tinnitus secondary to platinum agents. Currently the patient is in follow up and remains in a complete remission.
AU  - Porter,A
AU  - Barcelon,JM
AU  - Budker,RL
AU  - Marsh,L
AU  - Moriarty,JM
AU  - Aguiar,X
AU  - Rao,J
AU  - Ghorani,E
AU  - Kaur,B
AU  - Maher,G
AU  - Seckl,MJ
AU  - Konecny,GE
AU  - Cohen,JG
DO  - 10.1016/j.gore.2021.100782
EP  - 4
PY  - 2021///
SN  - 2352-5789
SP  - 1
TI  - Treatment of metastatic placental site trophoblastic tumor with surgery, chemotherapy, immunotherapy and coil embolization of multiple pulmonary arteriovenous fistulate
T2  - Gynecologic Oncology Reports
UR  - http://dx.doi.org/10.1016/j.gore.2021.100782
UR  - https://www.sciencedirect.com/science/article/pii/S2352578921000862?via%3Dihub
UR  - http://hdl.handle.net/10044/1/88821
VL  - 36
ER  -
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