Imperial College London
Alternate

ProfessorStratosPistikopoulos

Faculty of Engineering, Department of Chemical Engineering

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 6620e.pistikopoulos

 
 
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Location

 

C508Roderic Hill BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Krieger:2012:10.3182/20120829-3-HU-2029.00080,
author = {Krieger, A and Panoskaltsis, N and Mantalaris, A and Georgiadis, MC and Pistikopoulos, EN},
doi = {10.3182/20120829-3-HU-2029.00080},
journal = {IFAC Proceedings Volumes (IFAC-PapersOnline)},
pages = {385--390},
title = {Analysis of an individualized physiologically based model for anesthesia control},
url = {http://dx.doi.org/10.3182/20120829-3-HU-2029.00080},
volume = {45},
year = {2012}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - This paper presents a physiologically based, patient-specific, compartmental model for volatile anesthesia, consisting of a multiple blood and tissue compartmental model, adjusted to the weight, height, sex and age of the patient The predicted hypnotic effect measured by the Bispectral Index is linked to the arterial anesthetic concentration by an effect site compartment and the Hill-Equation To gain an in-depth understanding about the inuence of individual patient variables and characteristics, the pharmacokinetic and pharmacodynamic variables are analyzed for application of the model in future model predictive control In this study the pharmacodynamic variables are identified to have a higher inuence on the modeling output and are therefore more important to be identified accurately The initial sensitivity of the patient is calculated based on default physiological variables and updated during the course of anesthesia as a function of the obtained measurement of the Bispectral Index. © 2012 IFAC.
AU  - Krieger,A
AU  - Panoskaltsis,N
AU  - Mantalaris,A
AU  - Georgiadis,MC
AU  - Pistikopoulos,EN
DO  - 10.3182/20120829-3-HU-2029.00080
EP  - 390
PY  - 2012///
SN  - 1474-6670
SP  - 385
TI  - Analysis of an individualized physiologically based model for anesthesia control
T2  - IFAC Proceedings Volumes (IFAC-PapersOnline)
UR  - http://dx.doi.org/10.3182/20120829-3-HU-2029.00080
VL  - 45
ER  -
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