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@article{Gasull:2019:10.1016/j.envres.2018.11.027,
author = {Gasull, M and Pumarega, J and Kiviranta, H and Rantakokko, P and Raaschou-Nielsen, O and Bergdahl, IA and Sandanger, TM and Goñi, F and Cirera, L and Donat-Vargas, C and Alguacil, J and Iglesias, M and Tjønneland, A and Overvad, K and Mancini, FR and Boutron-Ruault, M-C and Severi, G and Johnson, T and Kühn, T and Trichopoulou, A and Karakatsani, A and Peppa, E and Palli, D and Pala, V and Tumino, R and Naccarati, A and Panico, S and Verschuren, M and Vermeulen, R and Rylander, C and Nøst, TH and Rodríguez-Barranco, M and Molinuevo, A and Chirlaque, M-D and Ardanaz, E and Sund, M and Key, T and Ye, W and Jenab, M and Michaud, D and Matullo, G and Canzian, F and Kaaks, R and Nieters, A and Nöthlings, U and Jeurnink, S and Chajes, V and Matejcic, M and Gunter, M and Aune, D and Riboli, E and Agudo, A and Gonzalez, CA and Weiderpass, E and Bueno-de-Mesquita, B and Duell, EJ and Vineis, P and Porta, M},
doi = {10.1016/j.envres.2018.11.027},
journal = {Environmental Research},
pages = {417--433},
title = {Methodological issues in a prospective study on plasma concentrations of persistent organic pollutants and pancreatic cancer risk within the EPIC cohort},
url = {http://dx.doi.org/10.1016/j.envres.2018.11.027},
volume = {169},
year = {2019}
}

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TY  - JOUR
AB  - BACKGROUND: The use of biomarkers of environmental exposure to explore new risk factors for pancreatic cancer presents clinical, logistic, and methodological challenges that are also relevant in research on other complex diseases. OBJECTIVES: First, to summarize the main design features of a prospective case-control study -nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort- on plasma concentrations of persistent organic pollutants (POPs) and pancreatic cancer risk. And second, to assess the main methodological challenges posed by associations among characteristics and habits of study participants, fasting status, time from blood draw to cancer diagnosis, disease progression bias, basis of cancer diagnosis, and plasma concentrations of lipids and POPs. Results from etiologic analyses on POPs and pancreatic cancer risk, and other analyses, will be reported in future articles. METHODS: Study subjects were 1533 participants (513 cases and 1020 controls matched by study centre, sex, age at blood collection, date and time of blood collection, and fasting status) enrolled between 1992 and 2000. Plasma concentrations of 22 POPs were measured by gas chromatography - triple quadrupole mass spectrometry (GC-MS/MS). To estimate the magnitude of the associations we calculated multivariate-adjusted odds ratios by unconditional logistic regression, and adjusted geometric means by General Linear Regression Models. RESULTS: There were differences among countries in subjects' characteristics (as age, gender, smoking, lipid and POP concentrations), and in study characteristics (as time from blood collection to index date, year of last follow-up, length of follow-up, basis of cancer diagnosis, and fasting status). Adjusting for centre and time of blood collection, no factors were significantly associated with fasting status. Plasma concentrations of lipids were related to age, body mass index, fasting, country, and smoking. We detected and quan
AU  - Gasull,M
AU  - Pumarega,J
AU  - Kiviranta,H
AU  - Rantakokko,P
AU  - Raaschou-Nielsen,O
AU  - Bergdahl,IA
AU  - Sandanger,TM
AU  - Goñi,F
AU  - Cirera,L
AU  - Donat-Vargas,C
AU  - Alguacil,J
AU  - Iglesias,M
AU  - Tjønneland,A
AU  - Overvad,K
AU  - Mancini,FR
AU  - Boutron-Ruault,M-C
AU  - Severi,G
AU  - Johnson,T
AU  - Kühn,T
AU  - Trichopoulou,A
AU  - Karakatsani,A
AU  - Peppa,E
AU  - Palli,D
AU  - Pala,V
AU  - Tumino,R
AU  - Naccarati,A
AU  - Panico,S
AU  - Verschuren,M
AU  - Vermeulen,R
AU  - Rylander,C
AU  - Nøst,TH
AU  - Rodríguez-Barranco,M
AU  - Molinuevo,A
AU  - Chirlaque,M-D
AU  - Ardanaz,E
AU  - Sund,M
AU  - Key,T
AU  - Ye,W
AU  - Jenab,M
AU  - Michaud,D
AU  - Matullo,G
AU  - Canzian,F
AU  - Kaaks,R
AU  - Nieters,A
AU  - Nöthlings,U
AU  - Jeurnink,S
AU  - Chajes,V
AU  - Matejcic,M
AU  - Gunter,M
AU  - Aune,D
AU  - Riboli,E
AU  - Agudo,A
AU  - Gonzalez,CA
AU  - Weiderpass,E
AU  - Bueno-de-Mesquita,B
AU  - Duell,EJ
AU  - Vineis,P
AU  - Porta,M
DO  - 10.1016/j.envres.2018.11.027
EP  - 433
PY  - 2019///
SN  - 0013-9351
SP  - 417
TI  - Methodological issues in a prospective study on plasma concentrations of persistent organic pollutants and pancreatic cancer risk within the EPIC cohort
T2  - Environmental Research
UR  - http://dx.doi.org/10.1016/j.envres.2018.11.027
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30529143
UR  - http://hdl.handle.net/10044/1/66459
VL  - 169
ER  -

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