Imperial College London
Alternate

ProfessorElioRiboli

Faculty of Medicine, School of Public Health

Chair in Cancer Epidemiology and Prevention
 
 
 
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Contact

 

e.riboli Website CV

 
 
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Assistant

 

Ms Julieta Dourado +44 (0)20 7594 3426

 
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Location

 

152Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@inproceedings{Heath:2020:10.1017/S0029665120001275,
author = {Heath, A and Muller, D and van, den Brandt P and Papadimitriou, N and Critselis, E and Weiderpass, E and Riboli, E and Tsilidis, K and Tzoulaki, I},
doi = {10.1017/S0029665120001275},
pages = {E179--E179},
publisher = {CAMBRIDGE UNIV PRESS},
title = {Nutrient-wide association study of 92 foods and nutrients and breast cancer risk},
url = {http://dx.doi.org/10.1017/S0029665120001275},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - CPAPER
AB  - Several dietary factors have been extensively investigated for associations with risk of breast cancer, but to date unequivocal evidence only exists for alcohol consumption. We sought to systematically evaluate the association between 92 dietary factors and breast cancer risk using a nutrient-wide association study approach. Using data from 272,098 women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we assessed dietary intake of 92 foods and nutrients estimated by dietary questionnaires. Cox regression with age as the time scale and adjustment for potential confounders, was used to quantify the association between each food or nutrient and risk of breast cancer. A false discovery rate (FDR) of 0.05 was used to select the set of foods and nutrients to evaluate in the independent replication cohort, the Netherlands Cohort Study (NLCS). During a median follow-up time of 15 years, 10,979 incident invasive breast cancers were identified in the women from the EPIC study. Six foods and nutrients were associated with risk of breast cancer when controlling the FDR at 0.05. Higher intake of alcohol overall was associated with a higher risk of breast cancer (hazard ratio (HR) for a 1 SD increment in intake = 1.05, 95% confidence interval (CI) 1.03–1.07), as was beer/cider intake and wine intake (HRs per 1 SD increment = 1.05, 95% CI 1.03–1.06 and 1.04, 95% CI 1.02–1.06, respectively), whereas higher intakes of fibre, apple/pear, and carbohydrates were associated with a lower risk of breast cancer (HRs per 1 SD increment = 0.96, 95% CI 0.94–0.98; 0.96, 95% CI 0.94–0.99; and 0.96, 95% CI 0.95–0.98, respectively). When evaluated in the NLCS (2368 invasive breast cancer cases), estimates for each of these foods and nutrients were similar in magnitude and direction, with the exception of beer/cider intake, which was not associated with risk of breast cancer in the NLCS. Our findings confirm the we
AU  - Heath,A
AU  - Muller,D
AU  - van,den Brandt P
AU  - Papadimitriou,N
AU  - Critselis,E
AU  - Weiderpass,E
AU  - Riboli,E
AU  - Tsilidis,K
AU  - Tzoulaki,I
DO  - 10.1017/S0029665120001275
EP  - 179
PB  - CAMBRIDGE UNIV PRESS
PY  - 2020///
SN  - 0029-6651
SP  - 179
TI  - Nutrient-wide association study of 92 foods and nutrients and breast cancer risk
UR  - http://dx.doi.org/10.1017/S0029665120001275
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000546638800112&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://www.cambridge.org/core/journals/proceedings-of-the-nutrition-society/article/nutrientwide-association-study-of-92-foods-and-nutrients-and-breast-cancer-risk/5F52A056C594CDC9C6BBD05A8B44BB81
UR  - http://hdl.handle.net/10044/1/104138
ER  -
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