Imperial College London
Alternate

ProfessorElaineHolmes

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Chemical Biology
 
 
 
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Contact

 

+44 (0)20 7594 3220elaine.holmes

 
 
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Location

 

661Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wolfer:2017:10.1186/s12967-017-1171-2,
author = {Wolfer, AM and Scott, AJ and Rueb, C and Gaudin, M and Darzi, A and Nicholson, JK and Holmes, E and Kinross, JM},
doi = {10.1186/s12967-017-1171-2},
journal = {JOURNAL OF TRANSLATIONAL MEDICINE},
title = {Longitudinal analysis of serum oxylipin profile as a novel descriptor of the inflammatory response to surgery},
url = {http://dx.doi.org/10.1186/s12967-017-1171-2},
volume = {15},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background:Oxylipins are potent lipid mediators demonstrated to initiate and regulate inflammation yet little is known regarding their involvement in the response to surgical trauma. As key modulators of the inflammatory response, oxylipins have the potential to provide novel insights into the physiological response to surgery and the pathophysiology of post-operative complications. We aimed to investigate the effects of major surgery on longitudinal oxylipin profile.Methods:Adults patients undergoing elective laparoscopic or open colorectal resections were included. Primary outcomes were serum oxylipin profile quantified by ultra high-performance liquid chromatography-mass spectrometry, serum white cell count and C-reactive protein concentration. Serum samples were taken at three time-points: pre-operative (day zero), early post-operative (day one) and late post-operative (day four/five).Results:Some 55 patients were included, of which 33 (60%) underwent surgery that was completed laparoscopically. Pre-operative oxylipin profiles were characterised by marked heterogeneity but surgery induced a common shift resulting in more homogeneity at the early post-operative time-point. By the late post-operative phase, oxylipin profiles were again highly variable. This evolution was driven by time-dependent changes in specific oxylipins. Notably, the levels of several oxylipins with anti-inflammatory properties (15-HETE and four regioisomers of DHET) were reduced at the early post-operative point before returning to baseline by the late post-operative period. In addition, levels of the pro-inflammatory 11-HETE rose in the early post-operative phase while levels of anti-thrombotic mediators (9-HODE and 13-HODE) fell; concentrations of all three oxylipins then remained fairly static from early to late post-operative phases. Compared to those undergoing laparoscopic surgery, patients undergoing open surgery had lower levels of some anti-inflammatory oxylipins (8,9-DHET and 17-HD
AU  - Wolfer,AM
AU  - Scott,AJ
AU  - Rueb,C
AU  - Gaudin,M
AU  - Darzi,A
AU  - Nicholson,JK
AU  - Holmes,E
AU  - Kinross,JM
DO  - 10.1186/s12967-017-1171-2
PY  - 2017///
SN  - 1479-5876
TI  - Longitudinal analysis of serum oxylipin profile as a novel descriptor of the inflammatory response to surgery
T2  - JOURNAL OF TRANSLATIONAL MEDICINE
UR  - http://dx.doi.org/10.1186/s12967-017-1171-2
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000400612100002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/48646
VL  - 15
ER  -
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