Publications
522 results found
Guess ND, Dornhorst A, Frost G, 2014, Effect of Inulin on Glucose Homeostasis in Subjects with Prediabetes, PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 73, Pages: E17-E17, ISSN: 0029-6651
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- Citations: 2
Steele K, Dickin E, Keerio MD, et al., 2013, Breeding low-glycemic index barley for functional food, FIELD CROPS RESEARCH, Vol: 154, Pages: 31-39, ISSN: 0378-4290
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- Citations: 10
Tan S-T, Rai B, Boustead L, et al., 2013, Assessing the Contribution of Dietary Factors to the Increased Prevalence of Insulin Resistance Amongst Uk Indian Asians Compared to Europeans, Scientific Sessions and Resuscitation Science Symposium of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0009-7322
Jones J, Barr S, Jennings C, et al., 2013, Training opportunities in preventive cardiology: MSc, Diploma and Certificate in Preventive Cardiology, British Journal of Cardiology, Vol: 20, ISSN: 0969-6113
Thomas EL, Fitzpatrick JA, Frost G, et al., 2013, Metabolic Syndrome, Overweight and Fatty Liver, Handbook of Nutrition and Food, 3rd Edition., Editors: Heber
Sam A, Busbridge M, Amin A, et al., 2013, Hepcidin levels in diabetes mellitus and polycystic ovary syndrome, Diabetic Medicine, Vol: 30, Pages: 1495-1499, ISSN: 0742-3071
Ismael NA, Posma JM, Frost G, et al., 2013, The role of metabonomics as a tool for augmenting nutritional information in epidemiological studies, Electrophoresis, Vol: 34, Pages: 2776-2786
Most chronic diseases have been demonstrated to have a link to nutrition. Within food and nutritional research there is a major driver to understand the relationship between diet and disease in order to improve health of individuals. However, the lack of accurate dietary intake assessment in free-living populations, makes accurate estimation of how diet is associated with disease risk difficult. Thus, there is a pressing need to find solutions to the inaccuracy of dietary reporting.Metabolic profiling of urine or plasma can provide an unbiased approach to characterizing dietary intake and various high throughput analytical platforms have been used in order to implement targeted and non-targeted assays in nutritional clinical trials and nutritional epidemiology studies.This review describes firstly the challenges presented in interpreting the relationship between diet and health within individual and epidemiological frameworks. Secondly we aim to explore how metabonomics can benefict different types of nutritional studies and discuss the critical importance of selecting appropriate analytical techniques in these studies. Thirdly we propose a strategy capable of providing accurate assessment of food intake within an epidemioligical framework in order establish accurate associations between diet and health.
Pedersen C, Lefevre S, Peters V, et al., 2013, Gut hormone release and appetite regulation in healthy non-obese participants following oligofructose intake. A dose-escalation study, APPETITE, Vol: 66, Pages: 44-53, ISSN: 0195-6663
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- Citations: 54
Goff LM, Griffin BA, Lovegrove JA, et al., 2013, Ethnic differences in beta-cell function, dietary intake and expression of the metabolic syndrome among UK adults of South Asian, black African-Caribbean and white-European origin at high risk of metabolic syndrome, DIABETES & VASCULAR DISEASE RESEARCH, Vol: 10, Pages: 315-323, ISSN: 1479-1641
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- Citations: 28
Sleeth M, Psichas A, Frost G, 2013, Weight gain and insulin sensitivity: a role for the glycaemic index and dietary fibre?, BRITISH JOURNAL OF NUTRITION, Vol: 109, Pages: 1539-1541, ISSN: 0007-1145
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- Citations: 3
Tan TM, Field BCT, McCullough KA, et al., 2013, Coadministration of Glucagon-Like Peptide-1 During Glucagon Infusion in Humans Results in Increased Energy Expenditure and Amelioration of Hyperglycemia, DIABETES, Vol: 62, Pages: 1131-1138, ISSN: 0012-1797
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- Citations: 162
Aljuraiban GS, Chan Q, Griep LO, et al., 2013, Relation of Nutrient-rich Diet to Blood Pressure and BMI: The INTERMAP Study, Scientific Sessions of the American-Heart-Association on Epidemiology and Prevention/Physical Activity, Nutrition and Metabolism, Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0009-7322
Guess ND, Dornhorst A, Frost GS, 2013, Fermentable Carbohydrate Decreases Food Intake and Promotes Weight Loss in Overweight Subjects with Prediabetes, DIABETIC MEDICINE, Vol: 30, Pages: 77-77, ISSN: 0742-3071
Behary P, Frost G, Baynes K, 2013, Relationship between eating behaviour pattern and glycaemic control in patients with Type 2 diabetes, DIABETIC MEDICINE, Vol: 30, Pages: 177-177, ISSN: 0742-3071
Dogan M, Brooks L, Bowe JE, et al., 2013, Expression and function of GPR43 in islets of Langerhans, DIABETIC MEDICINE, Vol: 30, Pages: 35-35, ISSN: 0742-3071
Jensen MG, Pedersen C, Kristensen M, et al., 2013, Review: efficacy of alginate supplementation in relation to appetite regulation and metabolic risk factors: evidence from animal and human studies, OBESITY REVIEWS, Vol: 14, Pages: 129-144, ISSN: 1467-7881
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- Citations: 43
Goff LM, Cowland DE, Hooper L, et al., 2013, Low glycaemic index diets and blood lipids: A systematic review and meta-analysis of randomised controlled trials, NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, Vol: 23, Pages: 1-10, ISSN: 0939-4753
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- Citations: 98
Carter M, Alwan NA, Burley V, et al., 2012, Use of information and communication technology to improve dietary assessment and tackle obesity, Public Health Science: a national conference dedicated to new research in public health
Arora T, Anastasovska J, Gibson G, et al., 2012, Effect of <i>Lactobacillus acidophilus</i> NCDC 13 supplementation on the progression of obesity in diet-induced obese mice, BRITISH JOURNAL OF NUTRITION, Vol: 108, Pages: 1382-1389, ISSN: 0007-1145
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- Citations: 66
Morgan LM, Shi J-W, Hampton SM, et al., 2012, Effect of meal timing and glycaemic index on glucose control and insulin secretion in healthy volunteers, BRITISH JOURNAL OF NUTRITION, Vol: 108, Pages: 1286-1291, ISSN: 0007-1145
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- Citations: 97
Walker CG, Loos RJF, Mander AP, et al., 2012, Genetic predisposition to type 2 diabetes is associated with impaired insulin secretion but does not modify insulin resistance or secretion in response to an intervention to lower dietary saturated fat, GENES AND NUTRITION, Vol: 7, Pages: 529-536, ISSN: 1555-8932
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- Citations: 4
Hill NE, Murphy KG, Brett S, et al., 2012, CAN THE GASTRIC HORMONE GHRELIN ATTENUATE CATABOLISM AND ENHANCE RECOVERY AND REHABILITATION IN A RODENT MODEL OF ZYMOSAN PERITONITIS?, INTENSIVE CARE MEDICINE, Vol: 38, Pages: S122-S122, ISSN: 0342-4642
Backhouse K, Sarac I, Shojaee-Moradie F, et al., 2012, Fatty acid flux and oxidation are increased by rimonabant in obese women, METABOLISM-CLINICAL AND EXPERIMENTAL, Vol: 61, Pages: 1220-1223, ISSN: 0026-0495
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- Citations: 9
Arora T, Loo RL, Anastasovska J, et al., 2012, Differential Effects of Two Fermentable Carbohydrates on Central Appetite Regulation and Body Composition, PLOS ONE, Vol: 7, ISSN: 1932-6203
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- Citations: 57
Bell J, Frost G, Thomas E, et al., 2012, Liposome encapsulated acetate (Lita) for the treatment of metabolic and oncogenic diseases
Cellular metabolic deregulation is a central premise in the development of many chronic diseases including cancer. Recently, there has been renewed interest in the potential of metabolic engineering, through the use of small molecules, to achieve metabolic retransformation of abnormal cells and tissues. However, making sufficient and sustain metabolic impact though this methods can be difficult, as it requires both identification of suitable small molecule(s) and an appropriate mode of delivery. Here we present a unique approach to tackle metabolic deregulation in vivo by the use of short-chain fatty acids (SCFAs) encapsulated in a liposomal nanoparticle delivery system. We demonstrate that liposomal delivery of the SCFA acetate leads to improved metabolic fitness of several organs, including liver and adipose tissue. Furthermore, treatment of mice consuming a high fat diet resulted in a significant reduction in hepatic fat accumulation, a reduction in inflammatory markers and modulation in key genes associated with fat metabolism, including UCP2, ACOX1 and CPT1A. These phenotypic and molecular events were underpinned by modulations in the epigenetic regulation of the liver. Finally, significant antitumor effects were observed in a xenograft murine model, including significant inhibition of tumour growth, following treatment. Our results demonstrate that this delivery system, liposomal encapsulated SCFAs, can be utilised as a novel method for the treatment of malignant transformation and metabolic deregulation in vivo.
Bodinham CL, Smith L, Wright J, et al., 2012, Dietary Fibre Improves First-phase Insulin Secretion in Overweight Individuals, PLOS ONE, Vol: 7, ISSN: 1932-6203
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- Citations: 58
Frost G, Wilkinson J, 2012, Compounds and their effects on appetite control and insulin sensitivity
Imperial innovations filed a UK priority patent application No1213629.7 entitled “compounds and their effects on appetite control and insulin sensitivity” in the name of Imperial Innovations and the University of Glasgow on the 31st of July 2012. We have filed a subsequent PCT application on the 31st of July 2013. The covers composition of matter and on a number of [novel prodrugs] or [propionate inulin esters] specifically designed to deliver short chain fatty acids to the gut. The patent also has claims directed to formulations and use in reduction of appetite/food intake/calorie intake. Claims are also directed and improving insulin sensitivity in a subject and for the treatment or prevention of diabetes or obesity.
Darzi J, Frost GS, Robertson MD, 2012, Effects of a novel propionate-rich sourdough bread on appetite and food intake, EUROPEAN JOURNAL OF CLINICAL NUTRITION, Vol: 66, Pages: 789-794, ISSN: 0954-3007
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- Citations: 25
Thomas EL, Al Saud NB, Durighel G, et al., 2012, The effect of preterm birth on adiposity and metabolic pathways and the implications for later life, CLINICAL LIPIDOLOGY, Vol: 7, Pages: 275-288, ISSN: 1758-4299
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- Citations: 13
Thomas EL, Frost G, Taylor-Robinson SD, et al., 2012, Excess body fat in obese and normal-weight subjects, NUTRITION RESEARCH REVIEWS, Vol: 25, Pages: 150-161, ISSN: 0954-4224
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- Citations: 104
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