Imperial College London
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DrGiovanniSena

Faculty of Natural Sciences, Department of Life Sciences

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 7448g.sena Website

 
 
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Location

 

450Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nakajima:2001:10.1038/35095061,
author = {Nakajima, K and Sena, G and Nawy, T and Benfey, PN},
doi = {10.1038/35095061},
journal = {Nature},
pages = {307--311},
title = {Intercellular movement of the putative transcription factor SHR in root patterning},
url = {http://dx.doi.org/10.1038/35095061},
volume = {413},
year = {2001}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Positional information is pivotal for establishing developmental patterning in plants1,2,3, but little is known about the underlying signalling mechanisms. The Arabidopsis root radial pattern is generated through stereotyped division of initial cells and the subsequent acquisition of cell fate4. short-root (shr) mutants do not undergo the longitudinal cell division of the cortex/endodermis initial daughter cell, resulting in a single cell layer with only cortex attributes5,6. Thus, SHR is necessary for both cell division and endodermis specification5,6. SHR messenger RNA is found exclusively in the stele cells internal to the endodermis and cortex, indicating that it has a non-cell-autonomous mode of action6. Here we show that the SHR protein, a putative transcription factor, moves from the stele to a single layer of adjacent cells, where it enters the nucleus. Ectopic expression of SHR driven by the promoter of the downstream gene SCARECROW (SCR) results in autocatalytic reinforcement of SHR signalling, producing altered cell fates and multiplication of cell layers. These results support a model in which SHR protein acts both as a signal from the stele and as an activator of endodermal cell fate and SCR-mediated cell division.
AU  - Nakajima,K
AU  - Sena,G
AU  - Nawy,T
AU  - Benfey,PN
DO  - 10.1038/35095061
EP  - 311
PY  - 2001///
SN  - 0028-0836
SP  - 307
TI  - Intercellular movement of the putative transcription factor SHR in root patterning
T2  - Nature
UR  - http://dx.doi.org/10.1038/35095061
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000171040500039&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/35095061
UR  - http://hdl.handle.net/10044/1/80564
VL  - 413
ER  -
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