Graham Wheeler is Deputy Head of Statistics at Imperial Clinical Trials Unit (ICTU) and Senior Lecturer in the School of Public Health. His clinical trial work includes studies in oncology, obesity, and diabetes management. Graham’s statistical research focusses on novel adaptive designs for clinical trials and improving their use in practice, Bayesian methods, and early phase trial problems. He is the co-lead for the “Introduction to Statistical Thinking and Data Analysis” module for Imperial College’s MPH course, and supervises students on the MPH and MSc Epidemiology degree programmes.
External to Imperial, Graham serves on several Independent Data Monitoring Committees as Chair and Independent Statistician, including trials in oncology, rheumatoid arthritis, and critical care. He also sits on the committees for the Early Phase Clinical Trials section of the NIHR Statistics Group, the NCRI’s Teenage and Young Adult & Germ Cell Therapy group, and is a member of the MRC Experimental Medicine Panel and a Statistical Ambassador for the Royal Statistical Society.
Graham holds degrees from the University of Warwick, the London School of Hygiene & Tropical Medicine, and Peterhouse, Cambridge. His PhD thesis developed adaptive designs for early phase clinical trials with a focus on oncology studies. Alongside his doctoral research, Graham was a Visiting Research Scholar at Columbia University's Mailman School of Public Health, funded by an MRC Centenary Award. Following a post-doctoral position at the MRC Biostatistics Unit, Graham moved to a Senior Statistician post in the CRUK & UCL Cancer Trials Centre at University College London in 2016, before joining Imperial College in March 2021.
et al., 2022, Addition of probenecid to oral beta-lactam antibiotics: a systematic review and meta-analysis, Journal of Antimicrobial Chemotherapy, ISSN:0305-7453
et al., 2022, Visualising harms in publications of randomised controlled trials: consensus and recommendations, Bmj: British Medical Journal, Vol:377, ISSN:0959-535X
et al., 2022, Early phase clinical trials extension to guidelines for the content of statistical analysis plans, Bmj, Vol:376, ISSN:1759-2151, Pages:1-10
et al., 2022, Effects of a group-based weight management programme on anxiety and depression: A randomised controlled trial (RCT), Plos One, Vol:17, ISSN:1932-6203, Pages:1-12
et al., 2021, Durable responses and low toxicity after fast off-rate CD19 chimeric antigen receptor-T therapy in adults with relapsed or refractory B-cell acute lymphoblastic leukemia., Journal of Clinical Oncology, Vol:39, ISSN:0732-183X, Pages:1-13