Publications
18 results found
Creese H-M, 2023, Discontinuation and adherence to oral 5-aminosalicylic-acid maintenance treatment in adolescents and young adults with ulcerative colitis: a retrospective cohort study in primary care, British Journal of General Practice, ISSN: 0960-1643
Creese H-M, Creese H-M, 2023, Risk Factors of Persistent Adolescent Thinness: Findings from the UK Millennium Cohort Study, BMC Public Health, ISSN: 1471-2458
Jayasooriya N, Baillie S, Blackwell J, et al., 2022, IMPACT OF TIME TO DIAGNOSIS ON INFLAMMATORY BOWEL DISEASE OUTCOMES: A SYSTEMATIC REVIEW AND META-ANALYSIS, Annual Meeting of the British-Society-of-Gastroenterology (BSG), Publisher: BMJ PUBLISHING GROUP, Pages: A52-A53, ISSN: 0017-5749
Blackwell J, Saxena S, Jayasooriya N, et al., 2022, Stoma Formation in Crohn's Disease and the Likelihood of Antidepressant Use: A Population-Based Cohort Study, CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, Vol: 20, Pages: E703-E710, ISSN: 1542-3565
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- Citations: 1
Jayasooriya N, Blackwell J, Saxena S, et al., 2022, Antidepressant medication use in Inflammatory Bowel Disease: a nationally representative population-based study, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Vol: 55, Pages: 1330-1341, ISSN: 0269-2813
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- Citations: 2
Jayasooriya N, Ballie S, Blackwell J, et al., 2022, Systematic review and meta-analysis: Diagnostic delay and the subsequent impact on the disease course of adult Inflammatory Bowel Disease, Publisher: OXFORD UNIV PRESS, Pages: I552-I552, ISSN: 1873-9946
Jayasooriya N, Ballie S, Blackwell J, et al., 2022, Systematic review and meta-analysis: Diagnostic delay and the subsequent impact on the disease course of adult Inflammatory Bowel Disease, Publisher: OXFORD UNIV PRESS, Pages: I552-I552, ISSN: 1873-9946
Reyes BD, Hargreaves DS, Creese H, 2021, Early-life maternal attachment and risky health behaviours in adolescence: Findings from the United Kingdom Millennium Cohort Study, BMC Public Health, Vol: 21, Pages: 1-11, ISSN: 1471-2458
BackgroundEarly uptake of multiple risky behaviours during adolescence, such as substance use, antisocial and sexual behaviours, can lead to poor health outcomes without timely interventions. This study investigated how early-life maternal attachment, or emotional bonds between mothers and infants, influenced later risky behaviours in adolescence alongside other potential explanatory pathways using the United Kingdom Millennium Cohort Study.MethodsTotal maternal attachment scores measured at 9 months using the Condon (1998) Maternal Postnatal Attachment Scale compared higher and lower attachment, where mothers in the lowest 10th percentile represented lower attachment. Multiple risky behaviours, defined as two or more risky behaviours (including smoking cigarettes, vaping, alcohol consumption, illegal drug use, antisocial behaviour, criminal engagement, unsafe sex, and gambling), were scored from 0 to 8 at age 17. Five multivariate logistic regression models examined associations between maternal attachment and multiple risky behaviours among Millennium Cohort Study members (n = 7796). Mediation analysis sequentially adjusted for blocks of explanatory mechanisms, including low attachment mechanisms (multiple births, infant prematurity, sex, breastfeeding, unplanned pregnancy and maternal age at birth), maternal depression, and social inequalities (single-parent status, socioeconomic circumstance by maternal education and household income) at 9 months and poor adolescent mental health at 14 years.ResultsChildren of mothers with lower maternal attachment at 9 months had 23% increased odds of multiple risky behaviours at 17 years (OR: 1.23, 95% CI: 1.00–1.50) in the unadjusted baseline model. All five explanatory blocks attenuated baseline odds. Low attachment mechanisms attenuated 13%, social inequalities 17%, and poor mental health 17%. Maternal depression attenuated the highest proportion (26%) after fully adjusting fo
Jayasooriya N, Pollok R, Blackwell J, et al., 2021, ADHERENCE AND DISCONTINUATION OF ORAL 5-AMINOSALICYLIC ACID AMONGST ADOLESCENTS AND YOUNG ADULTS WITH ULCERATIVE COLITIS, Publisher: BMJ PUBLISHING GROUP, Pages: A30-A31, ISSN: 0017-5749
Jayasooriya N, Saxena S, Blackwell J, et al., 2021, IMPACT OF CONSULTATION FREQUENCY AND TIME TO DIAGNOSIS ON SUBSEQUENT INFLAMMATORY BOWEL DISEASE OUTCOMES, Annual Meeting of the British-Society-of-Gastroenterology (BSG), Publisher: BMJ PUBLISHING GROUP, Pages: A78-A78, ISSN: 0017-5749
Creese H, Lai E, Mason K, et al., 2021, Disadvantage in early-life and persistent asthma in adolescents: a UK cohort study, THORAX, Vol: 77, Pages: 854-864, ISSN: 0040-6376
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- Citations: 1
Creese H, Saxena S, Nicholls D, et al., 2021, Internalized weight bias in the relationship between mental health and obesity in UK adolescents, Publisher: OXFORD UNIV PRESS, Pages: 562-562, ISSN: 1101-1262
Blackwell J, Saxena S, Petersen I, et al., 2021, Depression in individuals who subsequently develop inflammatory bowel disease: a population-based nested case-control study, GUT, Vol: 70, Pages: 1642-1648, ISSN: 0017-5749
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- Citations: 15
Blackwell J, Alexakis C, Saxena S, et al., 2021, The association between antidepressant medication use and steroid dependency in patients with ulcerative colitis: a population-based study, BMJ Open Gastroenterology, Vol: 8, ISSN: 2054-4774
Background: Animal studies indicate a potential protective role of antidepressant medication (ADM) in models of colitis but the effect of their use in humans with ulcerative colitis (UC) remains unclear. Objective: To study the relationship between ADM use and corticosteroid dependency in UC. Design: Using the Clinical Practice Research Datalink we identified patients diagnosed with UC between 2005-2016. We grouped patients according to serotonin selective reuptake inhibitor (SSRI) and tricyclic antidepressant (TCA) exposure in the 3 years following diagnosis: 'continuous users', 'intermittent users' and 'non users'. We used logistic regression to estimate the adjusted risk of corticosteroid dependency between ADM exposure groups. Results: We identified 6373 patients with UC. 5,230 (82%) use no ADMs, 627 (10%) were intermittent SSRI users and 282 (4%) were continuous SSRI users, 246 (4%) were intermittent TCA users and 63 (1%) were continuous TCA users. Corticosteroid dependency was more frequent in continuous SSRI and TCA users compared with non-users (19% vs. 24% vs. 14%, respectively, χ2 p=0.002). Intermittent SSRI and TCA users had similar risks of developing corticosteroid dependency to non-users (SSRI: OR 1.19, 95%CI 0.95-1.50, TCA: OR 1.14, CI 0.78-1.66). Continuous users of both SSRIs and TCAs had significantly higher risks of corticosteroid dependency compared to non-users (SSRI: OR 1.62, CI 1.15-2.27, TCA: OR 2.02, CI 1.07-3.81). Conclusions: Continuous ADM exposure has no protective effect in routine clinical practice in UC and identifies a population of patients requiring more intensive medical therapy. ADM use is a flag for potentially worse clinical outcomes in UC.
Jayasooriya N, Saxena S, Blackwell J, et al., 2021, Impact of consultation frequency and time to diagnosis on subsequent Inflammatory Bowel Disease outcomes, Publisher: OXFORD UNIV PRESS, Pages: S242-S243, ISSN: 1873-9946
Creese H-M, Hope S, Christie D, et al., 2021, Is earlier obesity associated with poorer executive functioning later in childhood? Findings from the Millennium Cohort Study, PEDIATRIC OBESITY, Vol: 16, ISSN: 2047-6310
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- Citations: 2
Creese H-M, Taylor-Robinson D, Saglani S, et al., 2020, Primary care of children and young people with asthma during the Covid-19 era, British Journal of General Practice, Vol: 70, Pages: 528-529, ISSN: 0960-1643
Around 1.1 million children and young people (CYP)currently receive treatment for asthma in the United Kingdom (UK)(1). The UK performs poorly compared with other European countries in children's outcomes of asthma management and has had amongst the highest number of reported asthma deaths in Europesince 1998 (2). We evaluate evidenceofthe impact of Covid-19 on CYP with asthma and consider what actionsgeneral practitioners can take to protect these children from serious harm.
Creese H, Mason K, Schluter DK, et al., 2020, Early years pathways to inequalities in childhood asthma? A causal mediation analysis, EUPHA, Publisher: OXFORD UNIV PRESS, Pages: V434-V434, ISSN: 1101-1262
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