Imperial College London
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DrHannahMaude

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Research Associate
 
 
 
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Contact

 

hannah.maude12

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jobbins:2023:10.1016/j.tem.2023.08.007,
author = {Jobbins, AM and Yu, S and Paterson, HAB and Maude, H and Kefala-Stavridi, A and Speck, C and Cebola, I and Vernia, S},
doi = {10.1016/j.tem.2023.08.007},
journal = {Trends in Endocrinology and Metabolism},
pages = {823--837},
title = {Pre-RNA splicing in metabolic homeostasis and liver disease},
url = {http://dx.doi.org/10.1016/j.tem.2023.08.007},
volume = {34},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The liver plays a key role in sensing nutritional and hormonal inputs to maintain metabolic homeostasis. Recent studies into pre-mRNA splicing and alternative splicing (AS) and their effects on gene expression have revealed considerable transcriptional complexity in the liver, both in health and disease. While the contribution of these mechanisms to cell and tissue identity is widely accepted, their role in physiological and pathological contexts within tissues is just beginning to be appreciated. In this review, we showcase recent studies on the splicing and AS of key genes in metabolic pathways in the liver, the effect of metabolic signals on the spliceosome, and therapeutic intervention points based on RNA splicing.
AU  - Jobbins,AM
AU  - Yu,S
AU  - Paterson,HAB
AU  - Maude,H
AU  - Kefala-Stavridi,A
AU  - Speck,C
AU  - Cebola,I
AU  - Vernia,S
DO  - 10.1016/j.tem.2023.08.007
EP  - 837
PY  - 2023///
SN  - 1043-2760
SP  - 823
TI  - Pre-RNA splicing in metabolic homeostasis and liver disease
T2  - Trends in Endocrinology and Metabolism
UR  - http://dx.doi.org/10.1016/j.tem.2023.08.007
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37673766
UR  - http://hdl.handle.net/10044/1/109900
VL  - 34
ER  -
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