Imperial College London
Alternate

DrIstvanNagy

Faculty of Medicine, Department of Surgery & Cancer

Reader in Nociceptive Mechanisms
 
 
 
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Contact

 

+44 (0)20 3315 8897i.nagy Website

 
 
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Assistant

 

Miss Steffi Klier +44 (0)20 3315 8816

 
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Location

 

G345Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Nagy:2008:10.1007/978-0-387-74349-3_1,
author = {Nagy, I and White, JPM and Paule, CC and Köfalvi, A},
booktitle = {Cannabinoids and the Brain},
doi = {10.1007/978-0-387-74349-3_1},
pages = {3--13},
title = {An historical introduction to the endocannabinoid and endovanilloid systems},
url = {http://dx.doi.org/10.1007/978-0-387-74349-3_1},
year = {2008}
}
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RIS format (EndNote, RefMan)

TY  - CHAP
AB  - Cannabis and chili pepper have been used for medical, gastronomical and recreational purposes for at least 8,000 years. Nevertheless, it was discovered only eight years ago that the cloned neuronal targets of their active principles, delta9-tetrahydrocannabinol (Δ9-THC) and capsaicin are related to each other, as they all can be activated by some arachidonic acid-derivative endogenous ligands. Here, we will summarize the history of man's relationship with cannabis and capsaicin, and we will detail the most important scientific keystones in the evolution of cannabinoid and vanilloid research, featuring the list of cannabinoid and capsaicin effects, the discovery of endogenous ligands and the cloning of receptors, namely, the CB1 and the CB2 cannabinoid receptor as well as the TRPV1 vanilloid receptor, where the endogenous and the plant-derived substances act upon. This chapter serves, therefore, as an introduction to Cannabinoids and the Brain, the book which will extensively describe the neuronal and, to some extent, the peripheral cannabinoid and vanilloid systems in molecular, pharmacological, physiological, pathological and neuropsychiatric viewpoints.
AU  - Nagy,I
AU  - White,JPM
AU  - Paule,CC
AU  - Köfalvi,A
DO  - 10.1007/978-0-387-74349-3_1
EP  - 13
PY  - 2008///
SN  - 9780387743486
SP  - 3
TI  - An historical introduction to the endocannabinoid and endovanilloid systems
T1  - Cannabinoids and the Brain
UR  - http://dx.doi.org/10.1007/978-0-387-74349-3_1
ER  -
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