Imperial College London
Alternate

DR JAMES A HARKER

Faculty of Medicine, National Heart & Lung Institute

Senior Lecturer in Respiratory Science
 
 
 
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Contact

 

+44 (0)20 7594 3171j.harker

 
 
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Location

 

360Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Harker:2023:10.3389/fimmu.2023.1221562,
author = {Harker, JA and Greene, TT and Barnett, BE and Bao, P and Dolgoter, A and Zuniga, EI},
doi = {10.3389/fimmu.2023.1221562},
journal = {Frontiers in Immunology},
title = {IL-6 and IL-27 play both distinct and redundant roles in regulating CD4 T-cell responses during chronic viral infection},
url = {http://dx.doi.org/10.3389/fimmu.2023.1221562},
volume = {14},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The IL-6 cytokine family signals through the common signal transduction molecule gp130 combined with a cytokine-specific receptor. Gp130 signaling on CD4 T cells is vital in controlling chronic infection of mice with lymphocytic choriomeningitis virus clone 13 (LCMV Cl13), but the precise role of individual members of the IL-6 cytokine family is not fully understood. Transcriptional analysis highlighted the importance of gp130 signaling in promoting key processes in CD4 T cells after LCMV Cl13 infection, particularly genes associated with T follicular helper (Tfh) cell differentiation and IL-21 production. Further, Il27r−/−Il6ra−/− mice failed to generate antibody or CD8 T-cell immunity and to control LCMV Cl13. Transcriptomics and phenotypic analyses of Il27r−/−Il6ra−/− Tfh cells revealed that IL-6R and IL-27R signaling was required to activate key pathways within CD4 T cells. IL-6 and IL-27 signaling has distinct and overlapping roles, with IL-6 regulating Tfh differentiation, IL-27 regulating CD4 T cell survival, and both redundantly promoting IL-21.
AU  - Harker,JA
AU  - Greene,TT
AU  - Barnett,BE
AU  - Bao,P
AU  - Dolgoter,A
AU  - Zuniga,EI
DO  - 10.3389/fimmu.2023.1221562
PY  - 2023///
SN  - 1664-3224
TI  - IL-6 and IL-27 play both distinct and redundant roles in regulating CD4 T-cell responses during chronic viral infection
T2  - Frontiers in Immunology
UR  - http://dx.doi.org/10.3389/fimmu.2023.1221562
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:001047423800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://www.frontiersin.org/articles/10.3389/fimmu.2023.1221562/full
UR  - http://hdl.handle.net/10044/1/107048
VL  - 14
ER  -
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