Publications
214 results found
Chambers JC, Kooner JS, 2001, Homocysteine: a novel risk factor for coronary heart disease in UK Indian Asians, HEART, Vol: 86, Pages: 121-122, ISSN: 1355-6037
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- Citations: 27
Chambers JC, Ueland PM, Wright M, et al., 2001, Investigation of relationship and protein-bound homocysteine between reduced, oxidized, and vascular endothelial function in healthy human subjects, CIRCULATION RESEARCH, Vol: 89, Pages: 187-192, ISSN: 0009-7330
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- Citations: 81
Chambers JC, Ueland PM, Wright M, et al., 2001, Investigation of relationship between reduced, oxidized, and protein-bound homocysteine and vascular endothelial function in healthy human subjects., Circ Res, Vol: 89, Pages: 187-192
Previous studies investigating homocysteine and vascular disease have relied on total plasma homocysteine as the sole index of homocysteine status. We examined the dynamic relationship between vascular endothelial function and concentrations of total, protein-bound oxidized, free oxidized, and reduced homocysteine to identify the homocysteine form associated with endothelial dysfunction in humans. We investigated 14 healthy volunteers (10 men, 4 women). Brachial artery flow-mediated dilatation was measured at baseline and at 30, 60, 120, 240, and 360 minutes after oral (1) L-methionine (50 mg/kg), (2) L-homocysteine (5 mg/kg), and (3) placebo. Plasma concentrations of total, protein-bound oxidized, free oxidized, and reduced homocysteine were measured at each time point, and nitroglycerin-induced dilatation at was assessed at 0, 120, and 360 minutes. Flow-mediated dilatation fell, and concentrations of total, protein-bound oxidized, free oxidized, and reduced homocysteine increased after oral homocysteine and oral methionine (all P<0.05 for difference in time course compared with placebo). Flow-mediated dilatation showed a reciprocal relationship with reduced homocysteine during both homocysteine and methionine loading. In both loading studies, peak reduction in flow-mediated dilatation coincided with maximal reduced homocysteine concentrations. In contrast, there was no consistent relationship between flow-mediated dilatation and free oxidized homocysteine, protein-bound oxidized homocysteine, or related species. Nitroglycerin-induced dilatation was unchanged by oral homocysteine and oral methionine (P>0.10 compared with placebo). Reduced homocysteine is closely associated with endothelial dysfunction during oral methionine and oral homocysteine loading. Our observations support the hypothesis that reduced homocysteine is the deleterious form of homocysteine for vascular function in vivo and suggest a less important role for other homocysteine species.
Chambers JC, Eda S, Bassett P, et al., 2001, C-reactive protein, insulin resistance, central obesity, and coronary heart disease risk in Indian Asians from the United Kingdom compared with European whites, CIRCULATION, Vol: 104, Pages: 145-150, ISSN: 0009-7322
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- Citations: 301
Chambers JC, Kooner JS, 2001, Homocysteine - an innocent bystander in vascular disease?, EUROPEAN HEART JOURNAL, Vol: 22, Pages: 717-719, ISSN: 0195-668X
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- Citations: 8
Malik IS, Bhatia VK, Kooner JS, 2001, Cost effectiveness of ramipril treatment for cardiovascular risk reduction, HEART, Vol: 85, Pages: 539-543, ISSN: 1355-6037
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- Citations: 27
Chambers JC, Fusi L, Malik IS, et al., 2001, Association of maternal endothelial dysfunction with preeclampsia, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol: 285, Pages: 1607-1612, ISSN: 0098-7484
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- Citations: 392
Chambers JC, Haskard DO, Kooner JS, 2001, Vascular endothelial function and oxidative stress mechanisms in patients with Behcet's syndrome, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 37, Pages: 517-520, ISSN: 0735-1097
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- Citations: 178
Malik IS, Bhatia VK, Kooner JS, 2001, Is ramipril cost-effective as well as clinically useful in reducing cardiovascular risk?, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 37, Pages: 511A-512A, ISSN: 0735-1097
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- Citations: 1
Bakhai A, Shibata MC, Collinson JR, et al., 2001, Bundle branch block carries a poor prognosis for patients presenting with acute coronary syndromes. Results from the prospective registry of acute ischaemic syndromes in the United Kingdom (PRAIS-UK), JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 37, Pages: 373A-373A, ISSN: 0735-1097
Chambers JC, Seddon MDI, Shah S, et al., 2001, Homocysteine - a novel risk factor for vascular disease, JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, Vol: 94, Pages: 10-13, ISSN: 0141-0768
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- Citations: 30
Chambers JC, Ueland PM, Obeid OA, et al., 2000, Improved vascular endothelial function after oral B vitamins - An effect mediated through reduced concentrations of free plasma homocysteine, CIRCULATION, Vol: 102, Pages: 2479-2483, ISSN: 0009-7322
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- Citations: 199
Chambers JC, Ireland H, Thompson E, et al., 2000, Methylenetetrahydrofolate reductase 677 <i>C</i>→<i>T</i> mutation and coronary heart disease risk in UK Indian Asians, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol: 20, Pages: 2448-2452, ISSN: 1079-5642
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- Citations: 49
Chambers JC, Refsum H, Obeid OA, et al., 2000, Oral B Vitamins improve vascular endothelial function in patients with coronary heart disease; An effect mediated through reduced concentrations of free plasma homocysteine., CIRCULATION, Vol: 102, Pages: 55-55, ISSN: 0009-7322
Chambers JC, Kooner JS, 2000, Inflammatory mechanisms may contribute to increased coronary heart disease mortality in UK Indian Asians, CIRCULATION, Vol: 102, Pages: 433-433, ISSN: 0009-7322
Chambers JC, Refsum H, Dore C, et al., 2000, Identification of the biologically active form of total plasma homocysteine in man, CIRCULATION, Vol: 102, Pages: 119-120, ISSN: 0009-7322
Chambers JC, Kooner JS, 2000, Homocysteine and heart disease in Indian Asians - Reply, LANCET, Vol: 355, Pages: 2250-2250, ISSN: 0140-6736
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- Citations: 1
Chambers JC, Obeid OA, Refsum H, et al., 2000, Plasma homocysteine concentrations and risk of coronary heart disease in UK Indian Asian and European men, LANCET, Vol: 355, Pages: 523-527, ISSN: 0140-6736
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- Citations: 210
Chambers JC, Wander GS, Kooner JS, 2000, Homocysteine and coronary heart disease amongst Indian Asians., Indian Heart J, Vol: 52, Pages: S5-S8, ISSN: 0019-4832
Chambers JC, Obeid OA, Kooner JS, 1999, Physiological increments in plasma homocysteine induce vascular endothelial dysfunction in normal human subjects, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol: 19, Pages: 2922-2927, ISSN: 1079-5642
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- Citations: 141
Chambers JC, Haskard DO, Kooner JS, 1999, Vascular endothelial function and oxidant stress mechanisms in patients with Behcet's disease, CIRCULATION, Vol: 100, Pages: 212-212, ISSN: 0009-7322
Chambers JC, Obeid OA, Refsum H, et al., 1999, Homocysteine and coronary heart disease risk in UK Indian Asians, CIRCULATION, Vol: 100, Pages: 869-869, ISSN: 0009-7322
Chambers JC, Fusi L, De Swiet M, et al., 1999, Endothelial function in women with single and multiple episodes of pre-eclampsia, CIRCULATION, Vol: 100, Pages: 106-106, ISSN: 0009-7322
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- Citations: 1
Chambers JC, McGregor A, Jean-Marie J, et al., 1999, Abnormalities of vascular endothelial function may contribute to increased coronary heart disease risk in UK Indian Asians, HEART, Vol: 81, Pages: 501-504, ISSN: 1355-6037
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- Citations: 54
Chambers JC, McGregor A, Jean-Marie J, et al., 1999, Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia - An effect reversible with vitamin C therapy, CIRCULATION, Vol: 99, Pages: 1156-1160, ISSN: 0009-7322
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- Citations: 377
Chambers JC, Lambiase P, Thomas N, et al., 1998, Endothelium dependent dilatation is impaired in first degree relatives of UK Indian Asian patients with premature coronary heart disease - evidence for a genetic influence., CIRCULATION, Vol: 98, Pages: 847-847, ISSN: 0009-7322
Chambers JC, Obeid O, Powell-Tuck J, et al., 1998, Elevated homocysteine concentrations are independently associated with hypertension in young men., CIRCULATION, Vol: 98, Pages: 517-517, ISSN: 0009-7322
Chambers JC, Rowley M, Medlock K, et al., 1998, Endothelium dependent dilation is impaired in healthy young women with a previous episode of pre-eclampsia., CIRCULATION, Vol: 98, Pages: 376-376, ISSN: 0009-7322
Chambers JC, Obeid O, McGregor A, et al., 1998, The relationship between hyperhomocysteinaemia and endothelial dysfunction is concentration-dependent, and present even at physiological levels., CIRCULATION, Vol: 98, Pages: 192-192, ISSN: 0009-7322
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- Citations: 4
Chambers JC, Obeid O, Hooper J, et al., 1998, Hyperhomocysteinamia may account for the excess coronary heart disease risk in UK Indian Asians compared to European whites., CIRCULATION, Vol: 98, Pages: 169-169, ISSN: 0009-7322
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