Imperial College London
Alternate

Emeritus ProfessorJeremyNicholson

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Emeritus Professor of Biological Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 3195j.nicholson Website

 
 
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Assistant

 

Ms Wendy Torto +44 (0)20 7594 3225

 
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Location

 

Office no. 665Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lewis:2017:10.1038/s41598-017-05689-z,
author = {Lewis, MC and Merrifield, CA and Berger, B and Cloarec, O and Duncker, S and Mercenier, A and Nicholson, JK and Holmes, E and Bailey, M},
doi = {10.1038/s41598-017-05689-z},
journal = {Scientific Reports},
title = {Early intervention with Bifidobacterium lactis NCC2818 modulates the host-microbe interface independent of the sustained changes induced by the neonatal environment.},
url = {http://dx.doi.org/10.1038/s41598-017-05689-z},
volume = {7},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Inflammatory and metabolic diseases can originate during early-life and have been correlated with shifts in intestinal microbial ecology. Here we demonstrate that minor environmental fluctuations during the early neonatal period had sustained effects on the developing porcine microbiota and host-microbe interface. These inter-replicate effects appear to originate during the first day of life, and are likely to reflect very early microbiota acquisition from the environment. We statistically link early systemic inflammation with later local increases in inflammatory cytokine (IL-17) production, which could have important enteric health implications. Immunity, intestinal barrier function, host metabolism and host-microbiota co-metabolism were further modified by Bifidobacterium lactis NCC2818 supplementation, although composition of the in situ microbiota remained unchanged. Finally, our robust model identified novel, strong correlations between urinary metabolites (eg malonate, phenylacetylglycine, alanine) and mucosal immunoglobulin (IgM) and cytokine (IL-10, IL-4) production, thus providing the possibility of the development of urinary 'dipstick' tests to assess non-accessible mucosal immune development and identify early precursors (biomarkers) of disease. These results have important implications for infants exposed to neonatal factors including caesarean delivery, antibiotic therapy and delayed discharge from hospital environments, which may predispose to the development of inflammatory and metabolic diseases in later life.
AU  - Lewis,MC
AU  - Merrifield,CA
AU  - Berger,B
AU  - Cloarec,O
AU  - Duncker,S
AU  - Mercenier,A
AU  - Nicholson,JK
AU  - Holmes,E
AU  - Bailey,M
DO  - 10.1038/s41598-017-05689-z
PY  - 2017///
SN  - 2045-2322
TI  - Early intervention with Bifidobacterium lactis NCC2818 modulates the host-microbe interface independent of the sustained changes induced by the neonatal environment.
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-017-05689-z
UR  - https://www.ncbi.nlm.nih.gov/pubmed/28706260
UR  - http://hdl.handle.net/10044/1/51724
VL  - 7
ER  -
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