Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Reader in Leukocyte Biology



+44 (0)20 7594 3162j.pease Website




109Sir Alexander Fleming BuildingSouth Kensington Campus





The Pease lab are interested in all aspects of chemokine biology with the ultimate view to therapeutically target ligands and receptors in pathological settings. 


Professor Shiranee Sriskandan, Imperial College London, Department of Medicine, SpyCEP and S. pyogenes virulence, 2010

Dr Arne Egesten, Department of Clinical Sciences, BMC B14, Tornavägen 10, SE–221 84 Lund, 2004

Dr Akos Heinemann, Department of Experimental and Clinical Pharmacology, Medical University Graz, A-8010 Graz, Austria, 2003

Guest Lectures

Cell Surface Binding of CXCL8 by Neutrophil Glycosaminoglycans Is Required for Efficient Navigation of Chemokine Gradients, Gordon Research Conference on Chemotactic Cytokines, PGA Catalunya Business and Convention Centre, Girona , Spain, 2016

Insights into biased agonist activity at chemokine receptor CCR4 by the identification of intrahelical and intracellular antagonist binding sites, First European Chemokine and Cell Migration Conference, Eurotel Victoria Villars-sur-Ollon, Switzerland, 2015

Biased Agonism at Chemokine Receptors - Challenge or Opportunity for Drug Discovery?, Gordon Research Conference on Chemotactic Cytokines, Mount Snow, West Dover, VT, USA, 2014

Natural and synthetic mutants illuminate chemokine biology., BSI Congress 2010,, Liverpool, UK., 2010

The CCR3/Eotaxin axis in asthma and allergy: lessons from small antagonists and agonists. 2009 BPS winter meeting, London, UK., BPS Winter meeting, London, UK, 2009

Molecular mechanisms underpinning the activation and antagonism of chemokine receptors., Human and viral chemokine receptors in cancer, mini symposium., Vrie Universiteit, Amsterdam, Netherlands., 2009

A sting in the tail of Serpentine Receptors, University of York. Biology Department, York, UK, 2009

Unravelling Serpentine Receptors., Animal Health Institute, Compton, UK, 2008

Unravelling Serpentine receptors., Pharmacology Department, University of Bath., Bath, UK., 2007

Walking the fine line between antagonism and agonism: small molecule antagonists and antagonists of chemokine receptors CCR1 and CCR3., Pharmacoepia Inc., Princeton, New Jersey, USA., 2007

Targeting chemokines and their receptors in allergic/respiratory inflammation., Royal Society of Medcine., London, UK., 2006

Chemokines and Their Receptors - What's the Big Attraction?, Institute for Animal Health, Compton, U.K., 2006

Chemokines and their receptors in inflammation – Bullets and targets, Royal Society of Medicine, London, UK, 2005

Assaying Chemokines and Chemotaxis, EuroSciCon, Birkbeck College, 2005

Anti-inflammatory Therapies - Chemokine Receptor Antagonists, Asthma Therapies 2004, Hilton Kensington, London, UK, 2004

Regulation of eosinophil trafficking in asthma and allergy, BIRAs Meeting, Drivers and Resolvers in Inflammation, The Barber Institute, University of Birmingham, UK, 2004

The eotaxin:CCR3 axis as a novel therapeutic target in the treatment of allergic disease., Symposium, "Immune Reactions of the Lung in Infection and Allergy” Hannover Medical School, Germany, 2004

The Molecular Biology of Chemokine Receptors., Department of Experimental and Clinical Pharmacology, University of Graz, Austria, 2003

Antagonism of the chemokine receptor CCR3 by synthetic and natural molecules, Department of Opthalmology, University College London, UK, 2002

The Molecular Biology of Chemokine Receptors : experiences with CCR3, Division of Cell and Molecular Biology, University of Reading, UK, 2002

Antagonism of Chemokine Receptors by Novel and Natural means, 5th World congress on Inflammation,, Edinburgh, U.K., 2001

Chemokine Receptor CCR3 - a novel target for future asthma therapies, Novartis Horsham Research Centre, Horsham UK, 2000

Chemokine receptors as novel therapeutic targets for the treatment of disease: Experiences with CCR3, Glaxo-Wellcome Research Centre, Stevenage, UK., 2000

Chemokine Receptors as Novel Therapeutic Targets., University of Brescia, Italy, 2000