Imperial College London
Portrait Picture

Professor José R Penadés

Faculty of Medicine, Department of Infectious Disease

Director MRC Centre for Molecular Bacteriology & Infection
 
 
 
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Contact

 

+44 (0)20 7594 8533j.penades Website

 
 
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Assistant

 

Mrs Anna Lee +44 (0)20 7594 2954

 
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Location

 

Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Arredondo-Alonso:2023:10.1038/s41467-023-39052-w,
author = {Arredondo-Alonso, S and Blundell-Hunter, G and Fu, Z and Gladstone, RA and Fillol-Salom, A and Loraine, J and Cloutman-Green, E and Johnsen, PJ and Samuelsen, Ø and Pöntinen, AK and Cléon, F and Chavez-Bueno, S and De, la Cruz MA and Ares, MA and Vongsouvath, M and Chmielarczyk, A and Horner, C and Klein, N and McNally, A and Reis, JN and Penadés, JR and Thomson, NR and Corander, J and Taylor, PW and McCarthy, AJ},
doi = {10.1038/s41467-023-39052-w},
journal = {Nature Communications},
pages = {1--17},
title = {Evolutionary and functional history of the Escherichia coli K1 capsule},
url = {http://dx.doi.org/10.1038/s41467-023-39052-w},
volume = {14},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Escherichia coli is a leading cause of invasive bacterial infections in humans. Capsule polysaccharide has an important role in bacterial pathogenesis, and the K1 capsule has been firmly established as one of the most potent capsule types in E. coli through its association with severe infections. However, little is known about its distribution, evolution and functions across the E. coli phylogeny, which is fundamental to elucidating its role in the expansion of successful lineages. Using systematic surveys of invasive E. coli isolates, we show that the K1-cps locus is present in a quarter of bloodstream infection isolates and has emerged in at least four different extraintestinal pathogenic E. coli (ExPEC) phylogroups independently in the last 500 years. Phenotypic assessment demonstrates that K1 capsule synthesis enhances E. coli survival in human serum independent of genetic background, and that therapeutic targeting of the K1 capsule re-sensitizes E. coli from distinct genetic backgrounds to human serum. Our study highlights that assessing the evolutionary and functional properties of bacterial virulence factors at population levels is important to better monitor and predict the emergence of virulent clones, and to also inform therapies and preventive medicine to effectively control bacterial infections whilst significantly lowering antibiotic usage.
AU  - Arredondo-Alonso,S
AU  - Blundell-Hunter,G
AU  - Fu,Z
AU  - Gladstone,RA
AU  - Fillol-Salom,A
AU  - Loraine,J
AU  - Cloutman-Green,E
AU  - Johnsen,PJ
AU  - Samuelsen,Ø
AU  - Pöntinen,AK
AU  - Cléon,F
AU  - Chavez-Bueno,S
AU  - De,la Cruz MA
AU  - Ares,MA
AU  - Vongsouvath,M
AU  - Chmielarczyk,A
AU  - Horner,C
AU  - Klein,N
AU  - McNally,A
AU  - Reis,JN
AU  - Penadés,JR
AU  - Thomson,NR
AU  - Corander,J
AU  - Taylor,PW
AU  - McCarthy,AJ
DO  - 10.1038/s41467-023-39052-w
EP  - 17
PY  - 2023///
SN  - 2041-1723
SP  - 1
TI  - Evolutionary and functional history of the Escherichia coli K1 capsule
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-023-39052-w
UR  - https://www.nature.com/articles/s41467-023-39052-w
UR  - http://hdl.handle.net/10044/1/104661
VL  - 14
ER  -
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