Imperial College London
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ProfessorJenniferQuint

Faculty of Medicine, School of Public Health

Professor of Respiratory Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 8821j.quint

 
 
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Location

 

.922Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Whittaker:2020:10.2147/COPD.S278981,
author = {Whittaker, H and Pimenta, J and Jarvis, D and Kiddle, S and Quint, J},
doi = {10.2147/COPD.S278981},
journal = {International Journal of COPD},
pages = {3079--3091},
title = {Characteristics associated with accelerated lung function decline in a primary care population with chronic obstructive pulmonary disease},
url = {http://dx.doi.org/10.2147/COPD.S278981},
volume = {2020},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Estimates for lung function decline in chronic obstructive pulmonary disease (COPD) have differed by study setting and have not been described in a UK primary care population.Purpose: To describe rates of FEV1 and FVC decline in COPD and investigate characteristics associated with accelerated decline.Patients and Methods: Current/ex-smoking COPD patients (35 years+) who had at least 2 FEV1 or FVC measurements ≥ 6 months apart were included using Clinical Practice Research Datalink. Patients were followed up for a maximum of 13 years. Accelerated rate of lung function decline was defined as the fastest quartile of decline using mixed linear regression, and association with baseline characteristics was investigated using logistic regression.Results: A total of 72,683 and 50,649 COPD patients had at least 2 FEV1 or FVC measurements, respectively. Median rates of FEV1 and FVC changes or decline were − 18.1mL/year (IQR: − 31.6 to − 6.0) and − 22.7mL/year (IQR: − 39.9 to − 6.7), respectively. Older age, high socioeconomic status, being underweight, high mMRC dyspnoea and frequent AECOPD or severe AECOPD were associated with an accelerated rate of FEV1 and FVC decline. Current smoking, mild airflow obstruction and inhaled corticosteroid treatment were additionally associated with accelerated FEV1 decline whilst women, sputum production and severe airflow obstruction were associated with accelerated FVC decline.Conclusion: Rate of FEV1 and FVC decline was similar and showed similar heterogeneity. Whilst FEV1 and FVC shared associations with baseline characteristics, a few differences highlighted the importance of both lung function measures in COPD progression. We identified important characteristics that should be monitored for disease progression.
AU  - Whittaker,H
AU  - Pimenta,J
AU  - Jarvis,D
AU  - Kiddle,S
AU  - Quint,J
DO  - 10.2147/COPD.S278981
EP  - 3091
PY  - 2020///
SN  - 1176-9106
SP  - 3079
TI  - Characteristics associated with accelerated lung function decline in a primary care population with chronic obstructive pulmonary disease
T2  - International Journal of COPD
UR  - http://dx.doi.org/10.2147/COPD.S278981
UR  - https://www.dovepress.com/characteristics-associated-with-accelerated-lung-function-decline-in-a-peer-reviewed-article-COPD
UR  - http://hdl.handle.net/10044/1/85049
VL  - 2020
ER  -
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