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@article{Taquet:2024:braincomms/fcad357,
author = {Taquet, M and Skorniewska, Z and Zetterberg, H and Geddes, JR and Mummery, CJ and Chalmers, JD and Ho, L-P and Horsley, A and Marks, M and Poinasamy, K and Raman, B and Leavy, OC and Richardson, M and Elneima, O and McAuley, HJC and Shikotra, A and Singapuri, A and Sereno, M and Saunders, RM and Harris, VC and Houchen-Wolloff, L and Mansoori, P and Greening, NJ and Harrison, EM and Docherty, AB and Lone, NI and Quint, J and Greenhalf, W and Wain, LV and Brightling, CE and Evans, RE and Harrison, PJ and Koychev, I and PHOSP-COVID, Study Collaborative Group},
doi = {braincomms/fcad357},
journal = {Brain Communications},
title = {Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury},
url = {http://dx.doi.org/10.1093/braincomms/fcad357},
volume = {6},
year = {2024}
}

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TY  - JOUR
AB  - A proportion of patients infected with severe acute respiratory syndrome coronavirus 2 experience a range of neuropsychiatric symptoms months after infection, including cognitive deficits, depression and anxiety. The mechanisms underpinning such symptoms remain elusive. Recent research has demonstrated that nervous system injury can occur during COVID-19. Whether ongoing neural injury in the months after COVID-19 accounts for the ongoing or emergent neuropsychiatric symptoms is unclear. Within a large prospective cohort study of adult survivors who were hospitalized for severe acute respiratory syndrome coronavirus 2 infection, we analysed plasma markers of nervous system injury and astrocytic activation, measured 6 months post-infection: neurofilament light, glial fibrillary acidic protein and total tau protein. We assessed whether these markers were associated with the severity of the acute COVID-19 illness and with post-acute neuropsychiatric symptoms (as measured by the Patient Health Questionnaire for depression, the General Anxiety Disorder assessment for anxiety, the Montreal Cognitive Assessment for objective cognitive deficit and the cognitive items of the Patient Symptom Questionnaire for subjective cognitive deficit) at 6 months and 1 year post-hospital discharge from COVID-19. No robust associations were found between markers of nervous system injury and severity of acute COVID-19 (except for an association of small effect size between duration of admission and neurofilament light) nor with post-acute neuropsychiatric symptoms. These results suggest that ongoing neuropsychiatric symptoms are not due to ongoing neural injury.
AU  - Taquet,M
AU  - Skorniewska,Z
AU  - Zetterberg,H
AU  - Geddes,JR
AU  - Mummery,CJ
AU  - Chalmers,JD
AU  - Ho,L-P
AU  - Horsley,A
AU  - Marks,M
AU  - Poinasamy,K
AU  - Raman,B
AU  - Leavy,OC
AU  - Richardson,M
AU  - Elneima,O
AU  - McAuley,HJC
AU  - Shikotra,A
AU  - Singapuri,A
AU  - Sereno,M
AU  - Saunders,RM
AU  - Harris,VC
AU  - Houchen-Wolloff,L
AU  - Mansoori,P
AU  - Greening,NJ
AU  - Harrison,EM
AU  - Docherty,AB
AU  - Lone,NI
AU  - Quint,J
AU  - Greenhalf,W
AU  - Wain,LV
AU  - Brightling,CE
AU  - Evans,RE
AU  - Harrison,PJ
AU  - Koychev,I
AU  - PHOSP-COVID,Study Collaborative Group
DO  - braincomms/fcad357
PY  - 2024///
SN  - 2632-1297
TI  - Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury
T2  - Brain Communications
UR  - http://dx.doi.org/10.1093/braincomms/fcad357
UR  - https://www.ncbi.nlm.nih.gov/pubmed/38229877
UR  - http://hdl.handle.net/10044/1/108983
VL  - 6
ER  -

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