Imperial College London
Alternate

DrJonathanSwann

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 0728j.swann

 
 
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Location

 

660Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mayneris-Perxachs:2016:10.1038/srep19780,
author = {Mayneris-Perxachs, J and Lima, AAM and Guerrant, RL and Leite, Á and Moura, AF and Lima, NL and Soares, AM and Havt, A and Moore, SR and Pinkerton, R and Swann, JR},
doi = {10.1038/srep19780},
journal = {Scientific Reports},
title = {Urinary N-methylnicotinamide and β-aminoisobutyric acid predict catch-up growth in undernourished Brazilian children},
url = {http://dx.doi.org/10.1038/srep19780},
volume = {6},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Enteric infections, enteropathy and undernutrition in early childhood are preventable risk factors for child deaths, impaired neurodevelopment, and later life metabolic diseases. However, the mechanisms linking these exposures and outcomes remain to be elucidated, as do biomarkers for identifying children at risk. By examining the urinary metabolic phenotypes of nourished and undernourished children participating in a case-control study in Semi-Arid Brazil, we identified key differences with potential relevance to mechanisms, biomarkers and outcomes. Undernutrition was found to perturb several biochemical pathways, including choline and tryptophan metabolism, while also increasing the proteolytic activity of the gut microbiome. Furthermore, a metabolic adaptation was observed in the undernourished children to reduce energy expenditure, reflected by increased N-methylnicotinamide and reduced β-aminoisobutyric acid excretion. Interestingly, accelerated catch-up growth was observed in those undernourished children displaying a more robust metabolic adaptation several months earlier. Hence, urinary N-methylnicotinamide and β-aminoisobutyric acid represent promising biomarkers for predicting short-term growth outcomes in undernourished children and for identifying children destined for further growth shortfalls. These findings have important implications for understanding contributors to long-term sequelae of early undernutrition, including cognitive, growth, and metabolic functions.
AU  - Mayneris-Perxachs,J
AU  - Lima,AAM
AU  - Guerrant,RL
AU  - Leite,Á
AU  - Moura,AF
AU  - Lima,NL
AU  - Soares,AM
AU  - Havt,A
AU  - Moore,SR
AU  - Pinkerton,R
AU  - Swann,JR
DO  - 10.1038/srep19780
PY  - 2016///
SN  - 2045-2322
TI  - Urinary N-methylnicotinamide and β-aminoisobutyric acid predict catch-up growth in undernourished Brazilian children
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/srep19780
UR  - http://hdl.handle.net/10044/1/29784
VL  - 6
ER  -
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