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@article{Hannan:2021:1361-6579/abd67a,
author = {Hannan, S and Aristovich, K and Faulkner, M and Avery, J and Walker, MC and Holder, DS},
doi = {1361-6579/abd67a},
journal = {Physiological Measurement},
pages = {1--19},
title = {Imaging slow brain activity during neocortical and hippocampal epileptiform events with electrical impedance tomography},
url = {http://dx.doi.org/10.1088/1361-6579/abd67a},
volume = {42},
year = {2021}
}

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TY  - JOUR
AB  - Objective. Electrical impedance tomography (EIT) is an imaging technique that produces tomographic images of internal impedance changes within an object using surface electrodes. It can be used to image the slow increase in cerebral tissue impedance that occurs over seconds during epileptic seizures, which is attributed to cell swelling due to disturbances in ion homeostasis following hypersynchronous neuronal firing and its associated metabolic demands. In this study, we characterised and imaged this slow impedance response during neocortical and hippocampal epileptiform events in the rat brain and evaluated its relationship to the underlying neural activity. Approach. Neocortical or hippocampal seizures, comprising repeatable series of high-amplitude ictal spikes, were induced by electrically stimulating the sensorimotor cortex or perforant path of rats anaesthetised with fentanyl-isoflurane. Transfer impedances were measured during ≥30 consecutive seizures, by applying a sinusoidal current through independent electrode pairs on an epicortical array, and combined to generate an EIT image of slow activity. Main results. The slow impedance responses were consistently time-matched to the end of seizures and EIT images of this activity were reconstructed reproducibly in all animals (p < 0.03125, N = 5). These displayed foci of activity that were spatially confined to the facial somatosensory cortex and dentate gyrus for neocortical and hippocampal seizures, respectively, and encompassed a larger volume as the seizure progressed. Centre-of-mass analysis of reconstructions revealed that this activity corresponded to the true location of the epileptogenic zone, as determined by EEG recordings and fast neural EIT measurements which were obtained simultaneously. Significance. These findings suggest that the slow impedance response presents a reliable marker of hypersynchronous neuronal activity during epileptic seizures and can thus be utilised for investigating the
AU  - Hannan,S
AU  - Aristovich,K
AU  - Faulkner,M
AU  - Avery,J
AU  - Walker,MC
AU  - Holder,DS
DO  - 1361-6579/abd67a
EP  - 19
PY  - 2021///
SN  - 0967-3334
SP  - 1
TI  - Imaging slow brain activity during neocortical and hippocampal epileptiform events with electrical impedance tomography
T2  - Physiological Measurement
UR  - http://dx.doi.org/10.1088/1361-6579/abd67a
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000615222100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://iopscience.iop.org/article/10.1088/1361-6579/abd67a
UR  - http://hdl.handle.net/10044/1/93412
VL  - 42
ER  -

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