Imperial College London
Alternate

ProfessorJesusGil

Faculty of Medicine, Institute of Clinical Sciences

Professor of Cell Proliferation
 
 
 
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Contact

 

+44 (0)20 3313 8263jesus.gil

 
 
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Location

 

ICTEM room 230ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Augert:2009:10.1038/embor.2008.255,
author = {Augert, A and Payré, C and Launoit, YD and Gil, J and Lambeau, G and Bernard, D},
doi = {10.1038/embor.2008.255},
journal = {EMBO Rep},
title = {The M-type receptor PLA2R regulates senescence through the p53 pathway},
url = {http://dx.doi.org/10.1038/embor.2008.255},
year = {2009}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Senescence is a stable proliferative arrest induced by various stresses such as telomere erosion, oncogenic or oxidative stress. Compelling evidence suggests that it acts as a barrier against tumour development. Describing new mechanisms that favour an escape from senescence can thus reveal new insights into tumorigenesis. To identify new genes controlling the senescence programme, we performed a loss-of-function genetic screen in primary human fibroblasts. We report that knockdown of the M-type receptor PLA2R (phospholipase A2 receptor) prevents the onset of replicative senescence and diminishes stress-induced senescence. Interestingly, expression of PLA2R increases during replicative senescence, and its ectopic expression results in premature senescence. We show that PLA2R regulates senescence in a reactive oxygen species-DNA damage-p53-dependent manner. Taken together, our study identifies PLA2R as a potential new tumour suppressor gene crucial in the induction of cellular senescence through the activation of the p53 pathway.
AU  - Augert,A
AU  - Payré,C
AU  - Launoit,YD
AU  - Gil,J
AU  - Lambeau,G
AU  - Bernard,D
DO  - 10.1038/embor.2008.255
PY  - 2009///
TI  - The M-type receptor PLA2R regulates senescence through the p53 pathway
T2  - EMBO Rep
UR  - http://dx.doi.org/10.1038/embor.2008.255
UR  - http://www.nature.com/embor/journal/vaop/ncurrent/abs/embor2008255.html
ER  -
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