Imperial College London
Alternate

ProfessorJimmyBell

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3506 4608jimmy.bell Website

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hameed:2017:10.1016/j.celrep.2017.05.066,
author = {Hameed, S and Patterson, M and Dhillo, W and Rahman, S and Ma, Y and Holton, C and Gogakos, A and Yeo, G and Lam, B and Polex-Wolf, J and Fenske, W and Bell, J and Anastasovska, J and Samarut, J and Bloom, S and Bassett, J and Williams, G and Gardiner, JV},
doi = {10.1016/j.celrep.2017.05.066},
journal = {Cell Reports},
pages = {2202--2209},
title = {Thyroid hormone receptor beta in the ventromedial hypothalamus is essential for the physiological regulation of food intake and body weight},
url = {http://dx.doi.org/10.1016/j.celrep.2017.05.066},
volume = {19},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The obesity epidemic is a significant global health issue. Improved understanding of the mechanisms that regulate appetite and body weight will provide the rationale for the design of anti-obesity therapies. Thyroid hormones play a key role in metabolic homeostasis through their interaction with thyroid hormone receptors (TRs), which function as ligand-inducible transcription factors. The TR-beta isoform (TRβ) is expressed in the ventromedial hypothalamus (VMH), a brain area important for control of energy homeostasis. Here, we report that selective knockdown of TRβ in the VMH of adult mice results in severe obesity due to hyperphagia and reduced energy expenditure. The observed increase in body weight is of a similar magnitude to murine models of the most extreme forms of monogenic obesity. These data identify TRβ in the VMH as a major physiological regulator of food intake and energy homeostasis.
AU  - Hameed,S
AU  - Patterson,M
AU  - Dhillo,W
AU  - Rahman,S
AU  - Ma,Y
AU  - Holton,C
AU  - Gogakos,A
AU  - Yeo,G
AU  - Lam,B
AU  - Polex-Wolf,J
AU  - Fenske,W
AU  - Bell,J
AU  - Anastasovska,J
AU  - Samarut,J
AU  - Bloom,S
AU  - Bassett,J
AU  - Williams,G
AU  - Gardiner,JV
DO  - 10.1016/j.celrep.2017.05.066
EP  - 2209
PY  - 2017///
SN  - 2211-1247
SP  - 2202
TI  - Thyroid hormone receptor beta in the ventromedial hypothalamus is essential for the physiological regulation of food intake and body weight
T2  - Cell Reports
UR  - http://dx.doi.org/10.1016/j.celrep.2017.05.066
UR  - https://www.sciencedirect.com/science/article/pii/S2211124717307234?via%3Dihub
UR  - http://hdl.handle.net/10044/1/48619
VL  - 19
ER  -
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