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@article{Chambers:2015:10.1016/S2213-8587(15)00127-8,
author = {Chambers, JC and Loh, M and Lehne, B and Drong, A and Kriebel, J and Motta, V and Wahl, S and Elliott, HR and Rota, F and Scott, WR and Zhang, W and Tan, S-T and Campanella, G and Chadeau-Hyam, M and Yengo, L and Richmond, RC and Adamowicz-Brice, M and Afzal, U and Bozaoglu, K and Mok, ZY and Ng, HK and Pattou, F and Prokisch, H and Rozario, MA and Tarantini, L and Abbott, J and Ala-Korpela, M and Albetti, B and Ammerpohl, O and Bertazzi, PA and Blancher, C and Caiazzo, R and Danesh, J and Gaunt, TR and de, Lusignan S and Gieger, C and Illig, T and Jha, S and Jones, S and Jowett, J and Kangas, AJ and Kasturiratne, A and Kato, N and Kotea, N and Kowlessur, S and Pitkaeniemi, J and Punjabi, P and Saleheen, D and Schafmayer, C and Soininen, P and Tai, E-S and Thorand, B and Tuomilehto, J and Wickremasinghe, AR and Kyrtopoulos, SA and Aitman, TJ and Herder, C and Hampe, J and Cauchi, S and Relton, CL and Froguel, P and Soong, R and Vineis, P and Jarvelin, M-R and Scott, J and Grallert, H a},
doi = {10.1016/S2213-8587(15)00127-8},
journal = {The Lancet Diabetes & Endocrinology},
pages = {526--534},
title = {Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study},
url = {http://dx.doi.org/10.1016/S2213-8587(15)00127-8},
volume = {3},
year = {2015}
}

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TY  - JOUR
AB  - BackgroundIndian Asians, who make up a quarter of the world's population, are at high risk of developing type 2 diabetes. We investigated whether DNA methylation is associated with future type 2 diabetes incidence in Indian Asians and whether differences in methylation patterns between Indian Asians and Europeans are associated with, and could be used to predict, differences in the magnitude of risk of developing type 2 diabetes.MethodsWe did a nested case-control study of DNA methylation in Indian Asians and Europeans with incident type 2 diabetes who were identified from the 8-year follow-up of 25372 participants in the London Life Sciences Prospective Population (LOLIPOP) study. Patients were recruited between May 1, 2002, and Sept 12, 2008. We did epigenome-wide association analysis using samples from Indian Asians with incident type 2 diabetes and age-matched and sex-matched Indian Asian controls, followed by replication testing of top-ranking signals in Europeans. For both discovery and replication, DNA methylation was measured in the baseline blood sample, which was collected before the onset of type 2 diabetes. Epigenome-wide significance was set at p<1×10−7. We compared methylation levels between Indian Asian and European controls without type 2 diabetes at baseline to estimate the potential contribution of DNA methylation to increased risk of future type 2 diabetes incidence among Indian Asians.Findings1608 (11·9%) of 13535 Indian Asians and 306 (4·3%) of 7066 Europeans developed type 2 diabetes over a mean of 8·5 years (SD 1·8) of follow-up. The age-adjusted and sex-adjusted incidence of type 2 diabetes was 3·1 times (95% CI 2·8–3·6; p<0·0001) higher among Indian Asians than among Europeans, and remained 2·5 times (2·1–2·9; p<0·0001) higher after adjustment for adiposity, physical activity, family history of type 2 diabetes, and baselin
AU  - Chambers,JC
AU  - Loh,M
AU  - Lehne,B
AU  - Drong,A
AU  - Kriebel,J
AU  - Motta,V
AU  - Wahl,S
AU  - Elliott,HR
AU  - Rota,F
AU  - Scott,WR
AU  - Zhang,W
AU  - Tan,S-T
AU  - Campanella,G
AU  - Chadeau-Hyam,M
AU  - Yengo,L
AU  - Richmond,RC
AU  - Adamowicz-Brice,M
AU  - Afzal,U
AU  - Bozaoglu,K
AU  - Mok,ZY
AU  - Ng,HK
AU  - Pattou,F
AU  - Prokisch,H
AU  - Rozario,MA
AU  - Tarantini,L
AU  - Abbott,J
AU  - Ala-Korpela,M
AU  - Albetti,B
AU  - Ammerpohl,O
AU  - Bertazzi,PA
AU  - Blancher,C
AU  - Caiazzo,R
AU  - Danesh,J
AU  - Gaunt,TR
AU  - de,Lusignan S
AU  - Gieger,C
AU  - Illig,T
AU  - Jha,S
AU  - Jones,S
AU  - Jowett,J
AU  - Kangas,AJ
AU  - Kasturiratne,A
AU  - Kato,N
AU  - Kotea,N
AU  - Kowlessur,S
AU  - Pitkaeniemi,J
AU  - Punjabi,P
AU  - Saleheen,D
AU  - Schafmayer,C
AU  - Soininen,P
AU  - Tai,E-S
AU  - Thorand,B
AU  - Tuomilehto,J
AU  - Wickremasinghe,AR
AU  - Kyrtopoulos,SA
AU  - Aitman,TJ
AU  - Herder,C
AU  - Hampe,J
AU  - Cauchi,S
AU  - Relton,CL
AU  - Froguel,P
AU  - Soong,R
AU  - Vineis,P
AU  - Jarvelin,M-R
AU  - Scott,J
AU  - Grallert,H
AU  - Bollati,V
AU  - Elliott,P
AU  - McCarthy,MI
AU  - Kooner,JS
DO  - 10.1016/S2213-8587(15)00127-8
EP  - 534
PY  - 2015///
SN  - 2213-8587
SP  - 526
TI  - Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study
T2  - The Lancet Diabetes & Endocrinology
UR  - http://dx.doi.org/10.1016/S2213-8587(15)00127-8
UR  - http://hdl.handle.net/10044/1/39485
VL  - 3
ER  -

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