Publications
165 results found
Greaves DR, Häkkinen T, Lucas AD, et al., 2001, Linked chromosome 16q13 chemokines, macrophage-derived chemokine, fractalkine, and thymus- and activation-regulated chemokine, are expressed in human atherosclerotic lesions., Arterioscler Thromb Vasc Biol, Vol: 21, Pages: 923-929
Chemokines are important mediators of macrophage and T-cell recruitment in a number of inflammatory pathologies, and chemokines expressed in atherosclerotic lesions may play an important role in mononuclear cell recruitment and macrophage differentiation. We have analyzed the expression of the linked chromosome 16q13 genes that encode macrophage-derived chemokine (MDC/CCL22), thymus- and activation-regulated chemokine (TARC/CCL17), and the CX(3)C chemokine fractalkine (CX(3)CL1) in primary macrophages and human atherosclerotic lesions by reverse transcription-polymerase chain reaction and immunohistochemistry. We show that macrophage expression of the chemokines MDC, fractalkine, and TARC is upregulated by treatment with the Th2-type cytokines interleukin-4 and interleukin-13. High levels of MDC, TARC, and fractalkine mRNA expression are seen in some, but not all, human arteries with advanced atherosclerotic lesions. Immunohistochemistry shows that MDC, fractalkine, and TARC are expressed by a subset of macrophages within regions of plaques that contain plaque microvessels. We conclude that MDC, fractalkine, and TARC, which are chromosome 16q13 chemokines, could play a role in mononuclear cell recruitment into atherosclerotic lesions and influence the subsequent inflammatory response. Macrophage-expressed chemokines upregulated by interleukin-4 may be useful surrogate markers for the presence of Th2-type immune responses in human atherosclerotic lesions.
Boyle JJ, Wilson B, Bicknell R, et al., 2000, Expression of angiogenic factor thymidine phosphorylase and angiogenesis in human atherosclerosis, JOURNAL OF PATHOLOGY, Vol: 192, Pages: 234-242, ISSN: 0022-3417
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- Citations: 46
Boyle JJ, 1999, Vascular smooth muscle cell apoptosis in atherosclerosis, INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol: 80, Pages: 197-203, ISSN: 0959-9673
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- Citations: 15
Bennett MR, Boyle JJ, 1998, Apoptosis of vascular smooth muscle cells in atherosclerosis, ATHEROSCLEROSIS, Vol: 138, Pages: 3-9, ISSN: 0021-9150
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- Citations: 84
Bennett MR, Macdonald K, Chan SW, et al., 1998, Cooperative interactions between RB and p53 regulate cell proliferation, cell senescence, and apoptosis in human vascular smooth muscle cells from atherosclerotic plaques, CIRCULATION RESEARCH, Vol: 82, Pages: 704-712, ISSN: 0009-7330
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- Citations: 152
Bennett MR, Boyle JJ, 1998, Apoptosis in cardiovascular disease, HEART, Vol: 79, Pages: 313-313, ISSN: 1355-6037
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- Citations: 2
Jenkins JT, Boyle JJ, McKay IC, et al., 1997, Vascular remodelling in intramyocardial resistance vessels in hypertensive human cardiac transplant recipients, HEART, Vol: 77, Pages: 353-356, ISSN: 1355-6037
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- Citations: 15
Jenkins J, Boyle JJ, Moss VA, et al., 1997, Three-dimensional reconstruction of abnormal intramural coronary arteries in human cardiac allograft biopsies, JOURNAL OF PATHOLOGY, Vol: 181, Pages: 247-250, ISSN: 0022-3417
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- Citations: 2
Boyle JJ, Jenkins J, McKay IC, et al., 1997, An assessment of the distortion of arteries due to sectioning in endomyocardial biopsies, JOURNAL OF PATHOLOGY, Vol: 181, Pages: 243-246, ISSN: 0022-3417
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- Citations: 6
Boyle JJ, 1997, Association of coronary plaque rupture and atherosclerotic inflammation, JOURNAL OF PATHOLOGY, Vol: 181, Pages: 93-99, ISSN: 0022-3417
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- Citations: 113
BOYLE JJ, LAWRIE G, MCPHADEN AR, et al., 1995, ARTERIAL LESIONS ASSOCIATED WITH MEDIAL DISORGANIZATION AND FIBROSIS IN ENDOMYOCARDIAL BIOPSIES FROM HUMAN CARDIAC ALLOGRAFTS, HISTOPATHOLOGY, Vol: 27, Pages: 439-444, ISSN: 0309-0167
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- Citations: 4
LINDOP GBM, BOYLE JJ, MCEWAN P, et al., 1995, VASCULAR STRUCTURE, SMOOTH-MUSCLE CELL PHENOTYPE AND GROWTH IN HYPERTENSION, JOURNAL OF HUMAN HYPERTENSION, Vol: 9, Pages: 475-478, ISSN: 0950-9240
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- Citations: 9
HAMILTON CA, BOYLE JJ, HUANG YT, et al., 1994, AGONIST DESENSITIZATION OF ALPHA(1) ADRENOCEPTORS AND ENDOTHELIN-1 RECEPTORS COUPLED TO PHOSPHATIDYLINOSITOL METABOLISM, FUNDAMENTAL & CLINICAL PHARMACOLOGY, Vol: 8, Pages: 162-172, ISSN: 0767-3981
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- Citations: 1
Direskeneli H, Boyle J, Ozdemir F, et al., IDENTIFICATION OF JAK1 AS A CANDIDATE INFLAMMATORY SIGNALLING PATHWAY BY GENOME-WIDE EXPRESSION PROFILING IN MONOCYTES FROM PATIENTS WITH BEHCET'S DISEASE, CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, Vol: 28, Pages: S108-S108, ISSN: 0392-856X
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- Citations: 1
Iqbal MB, Boyle JJ, Laffan MA, et al., DEXAMETHASONE EXERTS DUAL ACTIONS IN REDUCING MONOCYTE THROMBOGENIC PROFILE BY ENHANCING FIBRINOLYTIC ACTIVITY AND REDUCING PROCOAGULANT ACTIVITY, CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, Vol: 28, Pages: S156-S156, ISSN: 0392-856X
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