Imperial College London
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Dr Joseph Kwan MD FRCP FESO FAHA

Faculty of Medicine, Department of Brain Sciences

Honorary Senior Lecturer
 
 
 
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Contact

 

joseph.kwan

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gruia:2023:10.1136/bmjopen-2023-076653,
author = {Gruia, D-C and Trender, W and Hellyer, P and Banerjee, S and Kwan, J and Zetterberg, H and Hampshire, A and Geranmayeh, F},
doi = {10.1136/bmjopen-2023-076653},
journal = {BMJ Open},
title = {IC3 Protocol: a longitudinal observational study of cognition after stroke using novel digital health technology},
url = {http://dx.doi.org/10.1136/bmjopen-2023-076653},
volume = {13},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Introduction Stroke is a major cause of death and disability worldwide, frequently resulting in persistent cognitive deficits among survivors. These deficits negatively impact recovery and therapy engagement, and their treatment is consistently rated as high priority by stakeholders and clinicians. Although clinical guidelines endorse cognitive screening for poststroke management, there is currently no gold-standard approach for identifying cognitive deficits after stroke, and clinical stroke services lack the capacity for long-term cognitive monitoring and care. Currently, available assessment tools are either not stroke-specific, not in-depth or lack scalability, leading to heterogeneity in patient assessments.Methods and analysis To address these challenges, a cost-effective, scalable and comprehensive screening tool is needed to provide a stroke-specific assessment of cognition. The current study presents such a novel digital tool, the Imperial Comprehensive Cognitive Assessment in Cerebrovascular Disease (IC3), designed to detect both domain-general and domain-specific cognitive deficits in patients after stroke with minimal input from a health professional. To ensure its reliability, we will use multiple validation approaches, and aim to recruit a large normative sample of age-matched, gender-matched and education-matched UK-based controls. Moreover, the IC3 assessment will be integrated within a larger prospective observational longitudinal clinical trial, where poststroke cognition will be examined in tandem with brain imaging and blood biomarkers to identify novel multimodal biomarkers of recovery after stroke. This study will enable deeper cognitive phenotyping of patients at a large scale, while identifying those with highest risk of progressive cognitive decline, as well as those with greatest potential for recovery.Ethics and dissemination This study has been approved by South West—Frenchay Research Ethics Committee (IRAS 299333) and authorised by
AU  - Gruia,D-C
AU  - Trender,W
AU  - Hellyer,P
AU  - Banerjee,S
AU  - Kwan,J
AU  - Zetterberg,H
AU  - Hampshire,A
AU  - Geranmayeh,F
DO  - 10.1136/bmjopen-2023-076653
PY  - 2023///
SN  - 2044-6055
TI  - IC3 Protocol: a longitudinal observational study of cognition after stroke using novel digital health technology
T2  - BMJ Open
UR  - http://dx.doi.org/10.1136/bmjopen-2023-076653
UR  - http://hdl.handle.net/10044/1/108013
VL  - 13
ER  -
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