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@article{Crawford:2016:10.1192/bjp.bp.115.179747,
author = {Crawford, MJ and Barnicot, K and Patterson, S and Gold, C},
doi = {10.1192/bjp.bp.115.179747},
journal = {British Journal of Psychiatry},
pages = {6--8},
title = {Negative results in phase III trials of complex interventions: cause for concern or just good science?},
url = {http://dx.doi.org/10.1192/bjp.bp.115.179747},
volume = {209},
year = {2016}
}

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TY  - JOUR
AB  - Some phase III trials inevitably fail to replicate benefits of interventions seen in earlier smaller-scale studies. But the high failure rate in recent mental health trials is of concern. Proper consideration of trial processes and greater use of adaptive trial designs could ensure better use of available resources.
AU  - Crawford,MJ
AU  - Barnicot,K
AU  - Patterson,S
AU  - Gold,C
DO  - 10.1192/bjp.bp.115.179747
EP  - 8
PY  - 2016///
SN  - 1472-1465
SP  - 6
TI  - Negative results in phase III trials of complex interventions: cause for concern or just good science?
T2  - British Journal of Psychiatry
UR  - http://dx.doi.org/10.1192/bjp.bp.115.179747
UR  - http://hdl.handle.net/10044/1/30158
VL  - 209
ER  -

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