Publications
516 results found
Kempny A, Dimopoulos K, Alonso-Gonzalez R, et al., 2015, Multivariable mortality risk stratification in adult patients with eisenmenger syndrome, Congress of the European-Society-of-Cardiology (ESC), Publisher: Oxford University Press (OUP), Pages: 1138-1138, ISSN: 1522-9645
Diller G-P, Braeutigam A, Kempny A, et al., 2015, Depression requiring anti-depressant drug therapy in adult congenital heart disease: prevalence, risk factors, and prognostic value, European Heart Journal, Vol: 37, Pages: 771-782, ISSN: 1522-9645
Background Depression is prevalent in adults with congenital heart disease (ACHD), but limited data on the frequency of anti-depressant drug (ADD) therapy and its impact on outcome are available.Methods and results We identified all ACHD patients treated with ADDs between 2000 and 2011 at our centre. Of 6162 patients under follow-up, 204 (3.3%) patients were on ADD therapy. The majority of patients were treated with selective serotonin-reuptake inhibitors (67.4%), while only 17.0% of patients received tricyclic anti-depressants. Twice as many female patients used ADDs compared with males (4.4 vs. 2.2%, P < 0.0001). The percentage of patients on ADDs increased with disease complexity (P < 0.0001) and patient age (P < 0.0001). Over a median follow-up of 11.1 years, 507 (8.2%) patients died. After propensity score matching, ADD use was found to be significantly associated with worse outcome in male ACHD patients [hazard ratio 1.44 (95% confidence interval 1.17–1.84)]. There was no evidence that this excess mortality was directly related to ADD therapy, QT-prolongation, or malignant arrhythmias. However, males taking ADDs were also more likely to miss scheduled follow-up appointments compared with untreated counterparts, while no such difference in clinic attendance was seen in females.Conclusions The use of ADD therapy in ACHD relates to gender, age, and disease complexity. Although, twice as many female patients were on ADDs, it were their male counterparts, who were at increased mortality risk on therapy. Furthermore, males on ADDs had worse adherence to scheduled appointments suggesting the need for special medical attention and possibly psychosocial intervention for this group of patients.
Kempny A, Diller GP, Alonso-Gonzalez R, et al., 2015, Survival Prospects and Circumstance of Death in Contemporary Adult Patients with Congenital Heart Disease: The Shifting Focus of Mortality from the Perioperative Period to Long-Term Complications, Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 1137-1137, ISSN: 0195-668X
Merola A, Montanaro C, Kempny A, et al., 2015, Scimitar syndrome in adults: not always a benign condition, Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 112-112, ISSN: 0195-668X
D'Alto M, Merola A, Dimopoulos K, 2015, Pulmonary hypertension related to congenital heart disease: A comprehensive review, Global Cardiology Science and Practice, Vol: 2015
Pulmonary arterial hypertension (PAH) is a serious complication of congenital heart disease, causing an increase in morbidity and mortality. The progressive and irreversible pulmonary vascular disease is more often the consequence of a significant, uncorrected, left-to-right shunt. The rise in pulmonary vascular resistance may lead to the reversal of the shunt and cyanosis, condition known as Eisenmenger syndrome. The management of this population is challenging and requires specific expertise both for diagnosis and follow-up. The progress in the understanding of the underlying pathophysiology of this condition has promoted recent pharmacological trials. New therapeutic options are now available that could improve the longterm prognosis and the quality of life of these patients, but several controversial points still remain and need to be addressed. 2015 ElMaghawry, licensee Bloomsbury Qatar Foundation Journals.
Dimopoulos K, Kempny A, Alonso-Gonzalez R, et al., 2015, Percutaneous transluminal pulmonary angioplasty for the treatment of chronic thromboembolic pulmonary hypertension: Challenges and future directions, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 187, Pages: 401-403, ISSN: 0167-5273
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- Citations: 9
Di Mario C, Kilic ID, Yeh JSM, et al., 2015, Exclusion of a giant aneurysm post-Kawasaki disease with novel polyurethane covered stents, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 184, Pages: 664-666, ISSN: 0167-5273
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- Citations: 7
Kempny A, Diller G-P, Alonso-Gonzalez R, et al., 2015, Hypoalbuminaemia predicts outcome in adult patients with congenital heart disease, Heart, Vol: 101, Pages: 699-705, ISSN: 1355-6037
Background In patients with acquired heart failure, hypoalbuminaemia is associated with increased risk of death. The prevalence of hypoproteinaemia and hypoalbuminaemia and their relation to outcome in adult patients with congenital heart disease (ACHD) remains, however, unknown.Methods Data on patients with ACHD who underwent blood testing in our centre within the last 14 years were collected. The relation between laboratory, clinical or demographic parameters at baseline and mortality was assessed using Cox proportional hazards regression analysis.Results A total of 2886 patients with ACHD were included. Mean age was 33.3 years (23.6–44.7) and 50.1% patients were men. Median plasma albumin concentration was 41.0 g/L (38.0–44.0), whereas hypoalbuminaemia (<35 g/L) was present in 13.9% of patients. The prevalence of hypoalbuminaemia was significantly higher in patients with great complexity ACHD (18.2%) compared with patients with moderate (11.3%) or simple ACHD lesions (12.1%, p<0.001). During a median follow-up of 5.7 years (3.3–9.6), 327 (11.3%) patients died. On univariable Cox regression analysis, hypoalbuminaemia was a strong predictor of outcome (HR 3.37, 95% CI 2.67 to 4.25, p<0.0001). On multivariable Cox regression, after adjusting for age, sodium and creatinine concentration, liver dysfunction, functional class and disease complexity, hypoalbuminaemia remained a significant predictor of death.Conclusions Hypoalbuminaemia is common in patients with ACHD and is associated with a threefold increased risk of risk of death. Hypoalbuminaemia, therefore, should be included in risk-stratification algorithms as it may assist management decisions and timing of interventions in the growing ACHD population.
Ghez O, Dimopoulos K, Babu-Narayan SV, et al., 2015, Repair of tetralogy of Fallot-how much can we achieve with a single operation?, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 47, Pages: 535-536, ISSN: 1010-7940
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- Citations: 1
Bedair R, Babu-Narayan SV, Dimopoulos K, et al., 2015, Acceptance and psychological impact of implantable defibrillators amongst adults with congenital heart disease, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 181, Pages: 218-224, ISSN: 0167-5273
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- Citations: 22
Moceri P, Kempny A, Liodakis E, et al., 2015, Physiological differences between various types of Eisenmenger syndrome and relation to outcome, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 179, Pages: 455-460, ISSN: 0167-5273
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- Citations: 32
Moceri P, Bouvier P, Li W, et al., 2015, 0418: Survival advantage of Eisenmenger syndrome patients: the role of right ventricular transverse strain, Archives of Cardiovascular Diseases Supplements, Vol: 7, Pages: 93-93, ISSN: 1878-6480
D'Alto M, Scognamiglio G, Dimopoulos K, et al., 2015, Right Heart and Pulmonary Vessels Structure and Function, ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES, Vol: 32, Pages: 3-10, ISSN: 0742-2822
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- Citations: 19
Habib G, Lancellotti P, Antunes MJ, et al., 2015, [2015 ESC Guidelines for the management of infective endocarditis]., Kardiol Pol, Vol: 73, Pages: 963-1027
Garfield BE, Parfitt L, Harries C, et al., 2014, QUALITY OF LIFE IN IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION IS ASSOCIATED WITH QUADRICEPS FUNCTION AND SIZE, Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A76-A77, ISSN: 0040-6376
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- Citations: 1
Kempny A, Swan L, Dimopoulos K, 2014, Antidepressant Use in Pregnancy and the Risk of Cardiac Defects d, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 371, Pages: 1167-1167, ISSN: 0028-4793
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- Citations: 2
Wustmann K, Davies JE, Borgia F, et al., 2014, Pulmonary wave intensity analysis correlates with main pulmonary artery distensibility in patients with or without pulmonary hypertension, Annual Meeting of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 84-84, ISSN: 0195-668X
Diller GP, Kempny A, Dimopoulos K, et al., 2014, Impact of disease targeting therapies on quality of life and survival in patients with Eisenmenger syndrome: results of a Markov multi-state model of longitudinal data in 297 patients, Annual Meeting of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 43-44, ISSN: 0195-668X
Wustmann K, Davies JE, Borgia F, et al., 2014, Pulmonary artery compliance assessed by wave intensity analysis and its impact on the right ventricle in patients with or without pulmonary hypertension. First in humans, Annual Meeting of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 83-83, ISSN: 0195-668X
Diller GP, Kempny A, Inuzuka R, et al., 2014, Poor survival prospects of treatment naive Eisenmenger patients in the current era - a systematic review and report of own experience, Annual Meeting of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 44-44, ISSN: 0195-668X
Garcia-Aranda B, Revilla-Martinez M, Gonzalez RA, et al., 2014, Relation of the novel pulmonary hypertension EMPHASIS10 quality of life score to BNP and exercise capacity: early results, Annual Meeting of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 78-78, ISSN: 0195-668X
Diller GP, Braeutigam A, Kempny A, et al., 2014, Depressive symptoms requiring antidepressant drug therapy in adult congenital heart disease, relate to gender and disease severity and are independently associated with higher mortality, Annual Meeting of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 517-517, ISSN: 0195-668X
Kempny A, Diller GP, Dimopoulos K, et al., 2014, Attendance of outpatient clinic appointments amongst adults with congenital heart disease: predictors and relation to outcome, Annual Meeting of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 517-518, ISSN: 0195-668X
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- Citations: 1
Kempny A, Diller GP, Alonso-Gonzalez R, et al., 2014, Hypoalbuminemia predicts outcome in adult patients with congenital heart disease, Annual Meeting of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 516-516, ISSN: 0195-668X
Moceri P, Bouvier P, Cerboni P, et al., 2014, Right ventricular transverse strain is an independent predictor of mortality in pulmonary hypertension, Annual Meeting of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 84-84, ISSN: 0195-668X
Diller G-P, Kempny A, Inuzuka R, et al., 2014, Survival prospects of treatment naive patients with Eisenmenger: a systematic review of the literature and report of own experience, HEART, Vol: 100, Pages: 1366-1372, ISSN: 1355-6037
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- Citations: 61
Kempny A, Dimopoulos K, Gatzoulis MA, 2014, Single-ventricle physiology in the UK: an ongoing challenge of growing numbers and of growing complexity of congenital heart disease, HEART, Vol: 100, Pages: 1315-1316, ISSN: 1355-6037
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- Citations: 5
Keir G, Corte T, Dimopoulos K, et al., 2014, Non-invasive haemodynamic measurement to detect treatment response in pulmonary hypertension associated with fibrotic idiopathic interstitial pneumonia, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
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- Citations: 1
Scognamiglio G, Kempny A, Price LC, et al., 2014, C-reactive protein in adults with pulmonary arterial hypertension associated with congenital heart disease and its prognostic value, HEART, Vol: 100, Pages: 1335-1341, ISSN: 1355-6037
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- Citations: 21
Lanigan MJ, Chaney MA, Tissot C, et al., 2014, CASE 10-2014 Eisenmenger Syndrome: Close the Hole?, JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, Vol: 28, Pages: 1146-1153, ISSN: 1053-0770
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- Citations: 2
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