Imperial College London
Portrait Picture

ProfessorKevinMurphy

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Endocrinology & Metabolism
 
 
 
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Contact

 

+44 (0)20 3313 2156k.g.murphy Website

 
 
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Location

 

6N2DCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

180 results found

McGowan BM, Stanley SA, Donovan J, Thompson EL, Patterson M, Semjonous NM, Gardiner JV, Murphy KG, Ghatei MA, Bloom SRet al., 2008, Relaxin-3 stimulates the hypothalamic-pituitary-gonadal axis, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, Vol: 295, Pages: E278-E286, ISSN: 0193-1849

Journal article

Bech P, Winstanley V, Murphy KG, Sam AH, Meeran K, Ghatei MA, Bloom SRet al., 2008, Elevated cocaine- and amphetamine-regulated transcript immunoreactivity in the circulation of patients with neuroendocrine malignancy, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 93, Pages: 1246-1253, ISSN: 0021-972X

Journal article

Ramachandran R, Patterson M, Murphy KG, Dhillo WS, Patel S, Kazarian A, Ghatei MA, Bloom SRet al., 2008, Preanalytical factors affecting RIA measurement of plasma kisspeptin, CLINICAL CHEMISTRY, Vol: 54, Pages: 615-617, ISSN: 0009-9147

Journal article

le Roux CW, Borg CM, Murphy KG, Vincent RP, Ghatei MA, Bloom SRet al., 2008, Supraphysiological doses of intravenous PYY<sub>3-36</sub> cause nausea, but no additional reduction in food intake, ANNALS OF CLINICAL BIOCHEMISTRY, Vol: 45, Pages: 93-95, ISSN: 0004-5632

Journal article

Chaudhri OB, Salem V, Murphy KG, Bloom SRet al., 2008, Gastrointestinal satiety signals, ANNUAL REVIEW OF PHYSIOLOGY, Vol: 70, Pages: 239-255, ISSN: 0066-4278

Journal article

Dhillo WS, Chaudhri OB, Thompson EL, Murphy KG, Patterson M, Ramachandran R, Nijher GK, Amber V, Kokkinos A, Donaldson M, Ghatei MA, Bloom SRet al., 2007, Kisspeptin-54 stimulates gonadotropin release most potently during the Preovulatory phase of the menstrual cycle in women, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 92, Pages: 3958-3966, ISSN: 0021-972X

Journal article

Dhillo WS, Murphy KG, Bloom SR, 2007, The neuroendocrine physiology of kisspeptin in the human, REVIEWS IN ENDOCRINE & METABOLIC DISORDERS, Vol: 8, Pages: 41-46, ISSN: 1389-9155

Journal article

Murphy KG, Bloom SR, 2007, Nonpeptidic glucagon-like peptide 1 receptor agonists: A magic bullet for diabetes?, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 104, Pages: 689-690, ISSN: 0027-8424

Journal article

Murphy KG, Bloom SR, 2006, Gut hormones and the regulation of energy homeostasis, NATURE, Vol: 444, Pages: 854-859, ISSN: 0028-0836

Journal article

Murphy KG, Dhillo WS, Bloom SR, 2006, Gut peptides in the regulation of food intake and energy homeostasis, ENDOCRINE REVIEWS, Vol: 27, Pages: 719-727, ISSN: 0163-769X

Journal article

Dhillo WS, Savage P, Murphy KG, Chaudhri OB, Patterson M, Nijher GM, Foggo VM, Dancey GS, Mitchell H, Seckl MJ, Ghatei MA, Bloom SRet al., 2006, Plasma kisspeptin is raised in patients with gestational trophoblastic neoplasia and falls during treatment, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, Vol: 291, Pages: E878-E884, ISSN: 0193-1849

Journal article

Thompson EL, Murphy KG, Patterson M, Bewick GA, Stamp GWH, Curtis AE, Cooke JH, Jethwa PH, Todd JF, Ghatei MA, Bloom SRet al., 2006, Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male rats, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, Vol: 291, Pages: E1074-E1082, ISSN: 0193-1849

Journal article

Patterson M, Murphy KG, Thompson EL, Smith KL, Meeran K, Ghatei MA, Bloom SRet al., 2006, Microinjection of galanin-like peptide into the medial preoptic area stimulates food intake in adult male rats, JOURNAL OF NEUROENDOCRINOLOGY, Vol: 18, Pages: 742-747, ISSN: 0953-8194

Journal article

Dhillo WS, Murphy KG, Bloom S, 2006, Endocrinology: the next 60 years, JOURNAL OF ENDOCRINOLOGY, Vol: 190, Pages: 7-10, ISSN: 0022-0795

Journal article

Jethwa PH, Smith KL, Small CJ, Abbott CR, Darch SJ, Murphy KG, Seth A, Semjonous NM, Patel SR, Todd JF, Ghatei MA, Bloom SRet al., 2006, Neuromedin U partially mediates leptin-induced hypothalamo-pituitary adrenal (HPA) stimulation and has a physiological role in the regulation of the HPA axis in the rat, ENDOCRINOLOGY, Vol: 147, Pages: 2886-2892, ISSN: 0013-7227

Journal article

Patterson M, Murphy KG, Thompson EL, Patel S, Ghatei MA, Bloom SRet al., 2006, Administration of kisspeptin-54 into discrete regions of the hypothalamus potently increases plasma luteinising hormone and testosterone in male adult rats, JOURNAL OF NEUROENDOCRINOLOGY, Vol: 18, Pages: 349-354, ISSN: 0953-8194

Journal article

Murphy KG, Thompson EL, Patterson M, Bewick GA, Jethwa PH, Stamp GWH, Todd JF, Ghatei MA, Bloom SRet al., 2006, Continuous subcutaneous administration of kisspeptin-54 causes testicular degeneration in rats, 6th International Congress of Neuroendocrinology, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: 77-77, ISSN: 0091-3022

Conference paper

Patel AD, Stanley SA, Murphy KG, Frost GS, Gardiner JV, Kent AS, White NE, Ghatei MA, Bloorn SRet al., 2006, Ghrelin stimulates insulin-induced glucose uptake in adipocytes, REGULATORY PEPTIDES, Vol: 134, Pages: 17-22, ISSN: 0167-0115

Journal article

Murphy KG, Bloom SR, 2006, Are all fats created equal?, NATURE MEDICINE, Vol: 12, Pages: 32-33, ISSN: 1078-8956

Journal article

Mahmoodi M, Gardiner JV, Karam GRA, Khaksari M, Murphy KG, Ghatei MA, Bloom SRet al., 2005, Implantation of fibre encapsulated RIN 1056a cells transfected with NPY cDNA into the lateral ventricle of rats alters body weight, REGULATORY PEPTIDES, Vol: 132, Pages: 80-84, ISSN: 0167-0115

Journal article

Dhillo WS, Chaudhri OB, Patterson M, Thompson EL, Murphy KG, Badman MK, McGowan BM, Amber V, Patel S, Ghatei MA, Bloom SRet al., 2005, Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 90, Pages: 6609-6615, ISSN: 0021-972X

Journal article

Murphy KG, Bloom SR, 2005, Peripheral influences on central melanocortin neurons, PEPTIDES, Vol: 26, Pages: 1744-1752, ISSN: 0196-9781

Journal article

Jethwa PH, Small CJ, Smith KL, Seth A, Darch SJ, Abbott CR, Murphy KG, Todd JF, Ghatei MA, Bloom SRet al., 2005, Neuromedin U has a physiological role in the regulation of food intake and partially mediates the effects of leptin, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, Vol: 289, Pages: E301-E305, ISSN: 0193-1849

Journal article

Wynne K, Park AJ, Small CJ, Patterson M, Ellis SM, Murphy KG, Wren AM, Frost GS, Meeran K, Ghatei MA, Bloom SRet al., 2005, Subcutaneous oxyntomodulin reduces body weight in overweight and obese subjects - A double-blind, randomized, controlled trial, DIABETES, Vol: 54, Pages: 2390-2395, ISSN: 0012-1797

Journal article

Bewick GA, Dhillo WS, Darch SJ, Murphy KG, Gardiner JV, Jethwa PH, Kong WM, Ghatei MA, Bloom SRet al., 2005, Hypothalamic cocaine- and amphetamine-regulated transcript (CART) and agouti-related protein (AgRP) neurons coexpress the NOP<sub>1</sub> receptor and nociceptin alters CART and AgRP release, ENDOCRINOLOGY, Vol: 146, Pages: 3526-3534, ISSN: 0013-7227

Journal article

Murphy KG, 2005, Kisspeptins: Regulators of metastasis and the hypothalamic-pituitary-gonadal axis, JOURNAL OF NEUROENDOCRINOLOGY, Vol: 17, Pages: 519-525, ISSN: 0953-8194

Journal article

McGowan BMC, Stanley SA, Smith KL, White NE, Connolly MM, Thompson EL, Gardiner JV, Murphy KG, Ghatei MA, Bloom SRet al., 2005, Central relaxin-3 administration causes hyperphagia in male Wistar rats, ENDOCRINOLOGY, Vol: 146, Pages: 3295-3300, ISSN: 0013-7227

Journal article

Murphy KG, 2005, Dissecting the role of cocaine- and amphetamine-regulated transcript (CART) in the control of appetite., Brief Funct Genomic Proteomic, Vol: 4, Pages: 95-111, ISSN: 1473-9550

Cocaine- and amphetamine-regulated transcript (CART) codes for a neuropeptide system with a number of biological roles. The high conservation of CART across species suggests that it has an important role in mammalian physiology. CART is widely expressed in the central nervous system and the periphery, but is particularly concentrated in the hypothalamus. CART peptides, particularly CART (55-102), appear to have an important function in the regulation of energy homeostasis. This review aims to dissect the role of CART in appetite and energy expenditure. CART interacts with a number of central appetite circuits. Hypothalamic CART expression is regulated by a number of peripheral factors, including the adipose hormone leptin. Intracerebroventricular administration of CART (55-102) reduces appetite and stimulates energy expenditure. Hypothalamic CART may also play an orexigenic role under specific circumstances, however, as injection of CART (55-102) into specific hypothalamic nuclei increases food intake.

Journal article

Patterson M, Murphy KG, le Roux CW, Ghatei MA, Bloom SRet al., 2005, Characterization of ghrelin-like immunoreactivity in human plasma, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 90, Pages: 2205-2211, ISSN: 0021-972X

Journal article

Murphy KG, Abbott CR, Bloom SR, 2005, Editorial overview: Gut hormones come of age, Current Opinion in Endocrinology and Diabetes, Vol: 12, Pages: 53-55, ISSN: 1068-3097

Journal article

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