Publications
180 results found
Beale KEL, Murphy KG, Harrison EK, et al., 2011, Accurate Measurement of Body Weight and Food Intake in Environmentally Enriched Male Wistar Rats, OBESITY, Vol: 19, Pages: 1715-1721, ISSN: 1930-7381
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- Citations: 19
Ramachandran R, Bech P, Murphy KG, et al., 2011, PLASMA GASTRIN: SOMATOSTATIN RATIO IS DECREASED IN GASTRINOMAS, Annual Meeting on British-Society-of-Gasenterology, Publisher: B M J PUBLISHING GROUP, Pages: A117-A117, ISSN: 0017-5749
Amin A, Dhillo WS, Murphy KG, 2011, The central effects of thyroid hormones on appetite., J Thyroid Res, Vol: 2011
Obesity is a major public health issue worldwide. Current pharmacological treatments are largely unsuccessful. Determining the complex pathways that regulate food intake may aid the development of new treatments. The hypothalamic-pituitary-thyroid (HPT) axis has well-known effects on energy expenditure, but its role in the regulation of food intake is less well characterised. Evidence suggests that the HPT axis can directly influence food intake. Thyroid dysfunction can have clinically significant consequences on appetite and body weight. Classically, these effects were thought to be mediated by the peripheral effects of thyroid hormone. However, more recently, local regulation of thyroid hormone in the central nervous system (CNS) is thought to play an important role in physiologically regulating appetite. This paper focuses on the role of the HPT and thyroid hormone in appetite and provides evidence for potential new targets for anti-obesity agents.
Ramachandran R, Bech P, Murphy KG, et al., 2011, Plasma Somatostatin: Gastrin Ratio Improves the Diagnosis of Gastrinoma, 8th Annual ENETS Conference for the Diagnosis and Treatment of Neuroendocine Tumor Disease, Publisher: KARGER, Pages: 9-9, ISSN: 0028-3835
Kinsey-Jones JS, Murphy KG, 2011, Current models and strategies in the development of antiobesity drugs, ANIMAL MODELS: THEIR VALUE IN PREDICTING DRUG EFFICACY AND TOXICITY, Vol: 1245, Pages: 3-6
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- Citations: 3
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