Imperial College London
Alternate

ProfessorKathMaitland

Faculty of Medicine, Department of Surgery & Cancer

Professor of Tropical Paediatric Infectious Disease
 
 
 
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Contact

 

k.maitland CV

 
 
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Location

 

Based full-time at KEMRI/Wellcome Programme, KenyaQueen Elizabeth and Queen Mary HospitalSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Maitland:2005:10.1111/j.1365-2141.2004.05312.x,
author = {Maitland, K and Pamba, A and English, M and Peshu, N and Levin, M and Marsh, K and Newton, CRJC},
doi = {10.1111/j.1365-2141.2004.05312.x},
journal = {Br J Haematol},
pages = {393--400},
title = {Pre-transfusion management of children with severe malarial anaemia: a randomised controlled trial of intravascular volume expansion.},
url = {http://dx.doi.org/10.1111/j.1365-2141.2004.05312.x},
volume = {128},
year = {2005}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Symptomatic severe malarial anaemia (SMA) has a high fatality rate of 30-40%; most deaths occur in children awaiting blood transfusion. Blood transfusion services in most of Africa are not capable of delivering adequate supplies of safe blood in a timely manner to critically ill children with SMA. Contrary to widely held belief, hypovolaemia, rather than heart failure, has emerged as a common complication in such children. We examined the safety of pre-transfusion management (PTM) by volume expansion, aimed at stabilizing children and obviating the urgency for blood transfusion. Kenyan children with severe falciparum anaemia (haemoglobin <5 g/dl) and respiratory distress were randomly assigned to 20 ml/kg of 4.5% albumin or 0.9% saline or maintenance only (control) while awaiting blood transfusion. PTM was apparently safe since it did not lead to the development of pulmonary oedema or other adverse events. There was no significant difference in the primary outcome [mean percentage reduction in base excess between admission and 8 h (95% confidence interval)] between the control group 42% (19-66%) albumin group 44% (32-57%) and saline group 36% (16-57%); adjusted analysis of variance F=0.31, P=0.7. However, the number of children requiring emergency interventions was significantly greater in the control group, four of 18 (22%) than the saline group 0 of 20 (P=0.03). We have established the safety of this PTM in children with SMA whilst awaiting blood transfusion at a hospital with an adequate blood-banking program. The impact on mortality should be assessed where blood transfusion services are unable to supply emergency transfusions.
AU  - Maitland,K
AU  - Pamba,A
AU  - English,M
AU  - Peshu,N
AU  - Levin,M
AU  - Marsh,K
AU  - Newton,CRJC
DO  - 10.1111/j.1365-2141.2004.05312.x
EP  - 400
PY  - 2005///
SN  - 0007-1048
SP  - 393
TI  - Pre-transfusion management of children with severe malarial anaemia: a randomised controlled trial of intravascular volume expansion.
T2  - Br J Haematol
UR  - http://dx.doi.org/10.1111/j.1365-2141.2004.05312.x
UR  - https://www.ncbi.nlm.nih.gov/pubmed/15667544
VL  - 128
ER  -
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