Publications
46 results found
Paschalaki KE, Starke RD, Hu Y, et al., 2013, CIRCULATING ENDOTHELIAL PROGENITOR CELLS IN SMOKERS ARE DYSFUNCTIONAL DUE TO INCREASED DNA DAMAGE AND SENESCENCE, Annual Conference of the British-Cardiovascular-Society (BCS), Publisher: BMJ PUBLISHING GROUP, ISSN: 1355-6037
Reed DM, Kirkby NS, Foldes G, et al., 2013, Prostacyclin release pathways in stem cell derived endothelial cells, Experimental Biology 2013
Starke RD, Paschalaki KE, Dyer CE, et al., 2013, Cellular and molecular basis of von Willebrand disease: studies on blood outgrowth endothelial cells, Blood, Vol: 121, Pages: 2773-2784
Von Willebrand disease (VWD) is a heterogeneous bleeding disorder caused by decrease or dysfunction of von Willebrand factor (VWF). A wide range of mutations in the VWF gene have been characterized; however, their cellular consequences are still poorly understood. Here we have used a recently developed approach to study the molecular and cellular basis of VWD. We isolated blood outgrowth endothelial cells (BOECs) from peripheral blood of 4 type 1 VWD and 4 type 2 VWD patients and 9 healthy controls. We confirmed the endothelial lineage of BOECs, then measured VWF messenger RNA (mRNA) and protein levels (before and after stimulation) and VWF multimers. Decreased mRNA levels were predictive of plasma VWF levels in type 1 VWD, confirming a defect in VWF synthesis. However, BOECs from this group of patients also showed defects in processing, storage, and/or secretion of VWF. Levels of VWF mRNA and protein were normal in BOECs from 3 type 2 VWD patients, supporting the dysfunctional VWF model. However, 1 type 2M patient showed decreased VWF synthesis and storage, indicating a complex cellular defect. These results demonstrate for the first time that isolation of endothelial cells from VWD patients provides novel insight into cellular mechanisms of the disease
Starke RD, Paschalaki KE, Dyer CEF, et al., 2013, Cellular and molecular basis of von Willebrand disease: studies on blood outgrowth endothelial cells, BLOOD, Vol: 121, Pages: 2773-2784, ISSN: 0006-4971
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- Citations: 69
Paschalaki KE, Starke RD, Mercado N, et al., 2013, Endothelial progenitor cells in smokers are dysfunctional because of increased DNA damage and senescence, Spring Meeting for Clinician Scientists in Training, Publisher: ELSEVIER SCIENCE INC, Pages: 84-84, ISSN: 0140-6736
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- Citations: 2
Starke RD, Paschalaki KE, Dyer C, et al., 2012, Cellular and molecular basis of Von Willebrand disease: Studies on blood outgrowth endothelial cells, Atherosclerosis, Vol: 225, Pages: e5-e6, ISSN: 0021-9150
Paschalaki K, Starke R, Mercado N, et al., 2012, Blood outgrowth endothelial cells are senescent and dysfunctional in COPD due to increased DNA damage; implications for endothelial dysfunction, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Bikov A, Paschalaki K, Kharitonov S, et al., 2012, Expiratory flow rate and breath hold affect exhaled volatile organic compounds (VOC) in healthy subjects, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Starke RD, Paschalaki KE, Ferraro F, et al., 2012, Endothelial Von Willebrand factor regulates angiogenesis, 6th European Meeting on Vascular Biology and Medicine (EMVBM), Publisher: ELSEVIER SCIENCE INC, Pages: 318-319, ISSN: 1537-1891
Starke RD, Paschalaki KE, Ferraro F, et al., 2011, BLOOD-DERIVED ENDOTHELIAL PROGENITOR CELLS FROM VON WILLEBRAND'S DISEASE PATIENTS DEMONSTRATE THAT VON WILLEBRAND FACTOR REGULATES ANGIOGENESIS, Publisher: B M J PUBLISHING GROUP, Pages: 14-14, ISSN: 1355-6037
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- Citations: 1
Paschalaki K, Starke RD, Mercado N, et al., 2011, ENDOTHELIAL COLONY FORMING CELLS (ECFC) ARE SENESCENT AND DYSFUNCTIONAL IN COPD DUE TO REDUCED SIRTUIN-1 LEVELS, Publisher: B M J PUBLISHING GROUP, Pages: 20-20, ISSN: 1355-6037
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- Citations: 5
Drakopanagiotakis F, Paschalaki K, Abu-Hijleh M, et al., 2011, Cryptogenic and Secondary Organizing Pneumonia Clinical Presentation, Radiographic Findings, Treatment Response, and Prognosis, CHEST, Vol: 139, Pages: 893-900, ISSN: 0012-3692
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- Citations: 120
Starke RD, Ferraro F, Paschalaki KE, et al., 2011, Endothelial von Willebrand factor regulates angiogenesis, BLOOD, Vol: 117, Pages: 1071-1080, ISSN: 0006-4971
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- Citations: 358
Foldes G, Ali NN, Randi A, et al., 2011, PATHOGEN SENSING PATHWAYS IN HUMAN STEM CELL-DERIVED ENDOTHELIAL CELLS, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 4-4, ISSN: 1073-2322
Karakatsani A, Papakosta D, Rapti A, et al., 2009, Epidemiology of interstitial lung diseases in Greece, 15th Annual Congress of the European-Respiratory-Society, Publisher: W B SAUNDERS CO LTD, Pages: 1122-1129, ISSN: 0954-6111
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- Citations: 147
Karagiannidis N, Paschalaki K, Kastanakis E, et al., 2004, Cytokine profile in BAL of COPD patients with or without reversibility, CHEST 2004 Conference, Publisher: AMER COLL CHEST PHYSICIANS, Pages: 922S-922S, ISSN: 0012-3692
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- Citations: 1
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