Imperial College London
Alternate

DrKostasTsilidis

Faculty of Medicine, School of Public Health

Reader in Cancer Epidemiology and Prevention
 
 
 
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Contact

 

+44 (0)20 7594 2623k.tsilidis

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Seretis:2019:10.1038/s41598-019-45014-4,
author = {Seretis, A and Cividini, S and Markozannes, G and Tseretopoulou, X and Lopez, D and Ntzani, E and Tsilidis, K},
doi = {10.1038/s41598-019-45014-4},
journal = {Scientific Reports},
title = {Association between blood pressure and risk of cancer development: a systematic review and meta-analysis of observational studies},
url = {http://dx.doi.org/10.1038/s41598-019-45014-4},
volume = {9},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - With the exception of renal cell carcinoma, studies assessing the association between hypertension and other cancers are inconsistent. We conducted a meta-analysis to assess this evidence. We included observational studies investigating the association between any definition of hypertension or systolic and diastolic blood pressure and risk of any cancer, after searching PubMed until November 2017. We calculated summary relative risks (RR) and 95% confidence intervals (CI) using inverse-variance weighted random effects methods. A total of 148 eligible publications were identified out of 39,891 initially screened citations. Considering only evidence from 85 prospective studies, positive associations were observed between hypertension and kidney, colorectal and breast cancer. Positive associations between hypertension and risk of oesophageal adenocarcinoma and squamous cell carcinoma, liver and endometrial cancer were also observed, but the majority of studies did not perform comprehensive multivariable adjustments. Systolic and diastolic blood pressure were positively associated with risk of kidney cancer but not with other cancers. In addition to the previously well-described association between hypertension and risk of kidney cancer, the current meta-analysis suggested that hypertensive individuals may also be at higher risk of colorectal and breast cancer. However, careful interpretation is required as most meta-analyses included relatively small number of studies, several relative risks had weak or moderate magnitude and maybe affected by residual confounding.
AU  - Seretis,A
AU  - Cividini,S
AU  - Markozannes,G
AU  - Tseretopoulou,X
AU  - Lopez,D
AU  - Ntzani,E
AU  - Tsilidis,K
DO  - 10.1038/s41598-019-45014-4
PY  - 2019///
SN  - 2045-2322
TI  - Association between blood pressure and risk of cancer development: a systematic review and meta-analysis of observational studies
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-019-45014-4
UR  - http://hdl.handle.net/10044/1/70723
VL  - 9
ER  -
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