Imperial College London
Alternate

DrKostasTsilidis

Faculty of Medicine, School of Public Health

Reader in Cancer Epidemiology and Prevention
 
 
 
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Contact

 

+44 (0)20 7594 2623k.tsilidis

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Papadimitriou:2019:10.1101/668186,
author = {Papadimitriou, N and Dimou, N and Gill, D and Tzoulaki, I and Murphy, N and Riboli, E and Lewis, SJ and Martin, RM and Gunter, MJ and Tsilidis, KK},
doi = {10.1101/668186},
title = {Circulating concentrations of micro-nutrients and risk of breast cancer: A Mendelian randomization study},
url = {http://dx.doi.org/10.1101/668186},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The epidemiological literature reports inconsistent associations between consumption or circulating concentrations of micro-nutrients and breast cancer risk. We investigated associations between genetically determined concentrations of 11 micro-nutrients (beta-carotene, calcium, copper, folate, iron, magnesium, phosphorus, selenium, vitamin B6, vitamin B12 and zinc) and breast cancer risk using Mendelian randomization (MR).</jats:p></jats:sec><jats:sec><jats:title>Materials and methods</jats:title><jats:p>A two-sample MR study was conducted using 122,977 women with breast cancer, of whom 69,501 were estrogen receptor positive (ER<jats:sup>+ve</jats:sup>) and 21,468 were ER<jats:sup>−ve</jats:sup>, and 105,974 controls from the Breast Cancer Association Consortium. MR analyses were conducted using the inverse variance weighted approach, and sensitivity analyses were conducted to assess the impact of potential violations of MR assumptions.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>One standard deviation (SD: 0.08 mmol/L) higher genetically determined concentration of magnesium was associated with a 17% (odds ratio [OR]: 1.17, 95% confidence interval [CI]: 1.10 to 1.25, <jats:italic>P</jats:italic>=9.1 × 10<jats:sup>−7</jats:sup>) and 20% (OR: 1.20, 95% CI: 1.11 to 1.30, <jats:italic>P</jats:italic>=3.17 × 10<jats:sup>−6</jats:sup>) higher risk of overall and ER<jats:sup>+ve</jats:sup> breast cancer, respectively. An inverse association was observed for a SD (0.5 mg/dL) higher genetically determined phosphorus concentration and ER<jats:sup>−ve</jats:sup> breast cancer (OR: 0.84, 95% CI: 0.72 to 0.98, <jats:italic>P&l
AU  - Papadimitriou,N
AU  - Dimou,N
AU  - Gill,D
AU  - Tzoulaki,I
AU  - Murphy,N
AU  - Riboli,E
AU  - Lewis,SJ
AU  - Martin,RM
AU  - Gunter,MJ
AU  - Tsilidis,KK
DO  - 10.1101/668186
PY  - 2019///
TI  - Circulating concentrations of micro-nutrients and risk of breast cancer: A Mendelian randomization study
UR  - http://dx.doi.org/10.1101/668186
ER  -
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