Imperial College London
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Prof Liz Lightstone

Faculty of Medicine, Department of Immunology and Inflammation

Proconsul and Professor of Renal Medicine
 
 
 
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Contact

 

+44 (0)20 3313 3152l.lightstone Website CV

 
 
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Assistant

 

Miss Anjli Jagpal +44 (0)20 3313 3152

 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Webster:2016:10.2215/CJN.05610516,
author = {Webster, P and Webster, LM and Cook, HT and Horsfield, C and Seed, PT and Vaz, R and Santos, C and Lydon, I and Homsy, M and Lightstone, L and Bramham, K},
doi = {10.2215/CJN.05610516},
journal = {Clinical Journal of the American Society of Nephrology},
pages = {408--416},
title = {A multicenter cohort study of histologic findings and long-term outcomes of kidney disease in women who have been pregnant},
url = {http://dx.doi.org/10.2215/CJN.05610516},
volume = {12},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND AND OBJECTIVES: For many women pregnancy is the first contact with health services, thus providing an opportunity to identify renal disease. This study compares causes and long-term renal outcomes of biopsy-proven renal disease identified during pregnancy or within 1 year postpartum, with nonpregnant women. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Native renal biopsies (1997-2012), in women of childbearing age (16 to <50 years), from 21 hospitals were studied. The pregnancy-related diagnosis group included those women with abnormal urinalysis/raised creatinine identified during pregnancy or within 1 year postpartum. Pregnancy-related and control biopsies were matched for age and ethnicity (black versus nonblack). RESULTS: One hundred and seventy-three pregnancy-related biopsies (19 antenatal, 154 postpregnancy) were identified and matched with 1000 controls. FSGS was more common in pregnancy-related biopsies (32.4%) than controls (9.7%) (P<0.001) but there were no differences in Columbia classification. Women with a pregnancy-related diagnosis were younger (32.1 versus 34.2 years; P=0.004) and more likely to be black (26.0% versus 13.3%; P<0.001) than controls, although there were no differences in ethnicities in women with FSGS. The pregnancy-related group (excluding antenatal biopsies) was more likely to have a decline in Chronic Kidney Disease Epidemiology Collaboration eGFR in the follow-up period than the control group (odds ratio, 1.67; 95% confidence interval, 1.03 to 2.71; P=0.04), and this decline appeared to be more rapid (-1.33 versus -0.56 ml/min per 1.73 m(2) per year, respectively; P=0.045). However, there were no differences between groups in those who required RRT or who died. CONCLUSIONS: Pregnancy is an opportunity to detect kidney disease. FSGS is more common in women who have been pregnant than in controls, and disease identified in pregnancy or within 1 year postpartum is more likely to show a subsequent decline in
AU  - Webster,P
AU  - Webster,LM
AU  - Cook,HT
AU  - Horsfield,C
AU  - Seed,PT
AU  - Vaz,R
AU  - Santos,C
AU  - Lydon,I
AU  - Homsy,M
AU  - Lightstone,L
AU  - Bramham,K
DO  - 10.2215/CJN.05610516
EP  - 416
PY  - 2016///
SN  - 1555-905X
SP  - 408
TI  - A multicenter cohort study of histologic findings and long-term outcomes of kidney disease in women who have been pregnant
T2  - Clinical Journal of the American Society of Nephrology
UR  - http://dx.doi.org/10.2215/CJN.05610516
UR  - http://www.ncbi.nlm.nih.gov/pubmed/27940459
UR  - http://hdl.handle.net/10044/1/43390
VL  - 12
ER  -
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