Publications
355 results found
Jayasena CN, Abbara A, Izzi-Engbeaya C, et al., 2014, Reduced Levels of Plasma Kisspeptin During the Antenatal Booking Visit Are Associated With Increased Risk of Miscarriage, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 99, Pages: E2652-E2660, ISSN: 0021-972X
- Author Web Link
- Open Access Link
- Cite
- Citations: 48
Rolls AE, Riga CV, Bicknell CD, et al., 2014, Robot-Assisted Uterine Artery Embolization: A First-in-Woman Safety Evaluation of the Magellan System, JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, Vol: 25, Pages: 1841-1848, ISSN: 1051-0443
- Author Web Link
- Cite
- Citations: 23
Quinn SD, Vedelago J, Gedroyc W, et al., 2014, Safety and five-year re-intervention following magnetic resonance-guided focused ultrasound (MRgFUS) for uterine fibroids., Eur J Obstet Gynecol Reprod Biol, Vol: 182, Pages: 247-251
OBJECTIVE: To examine the safety and re-intervention rates following magnetic resonance-guided focused ultrasound (MRgFUS) for uterine fibroids at 5 years. To assess how the non-perfused volume (NPV), fibroid signal intensity and use of gonadotrophin-releasing hormone analogues (GnRHa) affect the re-intervention rates. STUDY DESIGN: Cohort study of women undergoing MRgFUS for treatment of their uterine fibroids between 2003 and 2010. RESULTS: Of 280 women undergoing MRgFUS the rate of minor complications was 3.9% and there were 3 serious complications (1.1%) including one skin burn, a fibroid expulsion and one case of persistent neuropathy. The NPVs achieved following MRgFUS have increased as the experience with this treatment has grown. In a 5-year follow-up study of 162 women, the overall re-intervention rate was 58.64%, but in those treatments with greater than 50% NPV the re-intervention rate was 50%. CONCLUSION: MRgFUS treatment of uterine fibroids is a safe treatment for uterine fibroids. The re-intervention rate at 5 years is high, but the improvements in NPVs achieved may further improve the long term results.
Gargasole C, Quinn S, Cartwright R, et al., 2014, THE IMPACT OF BULKY FIBROIDS ON LUTS: DOES EITHER THE SIZE OR THE POSITION MAKE A DIFFERENCE?, 44th Annual Meeting of the International-Continence-Society (ICS), Publisher: WILEY-BLACKWELL, Pages: 921-921, ISSN: 0733-2467
Abbara A, Jayasena CN, Izzi-Engbeaya C, et al., 2014, Plasma Kisspeptin Measurement during Early Pregnancy Is a Highly Predictive Marker of Subsequent Miscarriage, Publisher: ENDOCRINE SOC, ISSN: 0163-769X
Saravelos SH, Regan L, 2014, Unexplained Recurrent Pregnancy Loss, OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA, Vol: 41, Pages: 157-+, ISSN: 0889-8545
- Author Web Link
- Cite
- Citations: 43
Demetriou C, Abu-Amero S, Thomas AC, et al., 2014, Paternally expressed, imprinted insulin-like growth factor-2 in chorionic villi correlates significantly with birth weight, PLoS ONE, Vol: 9, ISSN: 1932-6203
Context: Fetal growth involves highly complex molecular pathways. IGF2 is a key paternally expressed growth hormonethat is critical for in utero growth in mice. Its role in human fetal growth has remained ambiguous, as it has only beenstudied in term tissues. Conversely the maternally expressed growth suppressor, PHLDA2, has a significant negativecorrelation between its term placental expression and birth weight.Objective: The aim of this study is to address the role in early gestation of expression of IGF1, IGF2, their receptors IGF1R andIGF2R, and PHLDA2 on term birth weight.Design: Real-time quantitative PCR was used to investigate mRNA expression of IGF1, IGF2, IGF1R, IGF2R and PHLDA2 inchorionic villus samples (CVS) (n = 260) collected at 11–13 weeks’ gestation. Expression was correlated with term birthweight using statistical package R including correction for several confounding factors.Results: Transcript levels of IGF2 and IGF2R revealed a significant positive correlation with birth weight (0.009 and 0.04,respectively). No effect was observed for IGF1, IGF1R or PHLDA2 and birth weight. Critically, small for gestational age (SGA)neonates had significantly lower IGF2 levels than appropriate for gestational age neonates (p = 3?661027).Interpretation: Our findings show that IGF2 mRNA levels at 12 weeks gestation could provide a useful predictor of futurefetal growth to term, potentially predicting SGA babies. SGA babies are known to be at a higher risk for type 2 diabetes. Thisresearch reveals an imprinted, parentally driven rheostat for in utero growth.
Demetriou C, Abu-Amero S, Thomas AC, et al., 2013, Paternally expressed, imprinted insulin-like growth factor-2 in chorionic villi correlates significantly with birth weight, 24th Mammalian Genetics and Development Workshop of the Genetics-Society, Publisher: HINDAWI LTD, Pages: 183-183, ISSN: 0016-6723
Quinn SD, Vedelago J, Kashef E, et al., 2013, Measurement of uterine fibroid volume: a comparative accuracy and validation of methods study, EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, Vol: 171, Pages: 161-165, ISSN: 0301-2115
- Author Web Link
- Cite
- Citations: 11
Quinn SD, Vedelago J, Regan L, et al., 2013, Safety and treatment volumes achieved following new developments of the magnetic resonance-guided focused ultrasound system in the treatment of uterine fibroids: a cohort study., J Ther Ultrasound, Vol: 1, Pages: 1-6, ISSN: 2050-5736
BACKGROUND: This research investigates whether modifications to the magnetic resonance-guided focused ultrasound ablation of uterine fibroid (MRgFUS) system used resulted in improved treatment volumes of uterine fibroids, while maintaining safety. METHODS: This study is a prospective cohort analysis of 34 women undergoing the ExAblate 2100 MRgFUS treatment for their uterine fibroids. RESULTS: The percentage of non-perfused volume (NPV) achieved with the ExAblate 2100 system was 54.92% compared with 50.49 % with the ExAblate 2000 system over the preceding year (p = 0.543). The ExAblate 2100 system resulted in a greater NPV in hyper-intense fibroids compared with the ExAblate 200 system (43.20% versus 36.33%, p = 0.005). There have been no recorded hospital admissions, no skins burns, and no reported major adverse events since the introduction of this new system. CONCLUSION: Overall, the new system has thus far shown an encouraging safety record and an improvement in non-perfused volumes achieved, especially in hyper-intense fibroids.
Saravelos S, Addo N, Aziz M, et al., 2013, Pregnancy outcomes in women with primary (no previous live births) versus secondary (one or more previous live births) unexplained recurrent miscarriage: novel findings in over a thousand women referred to a large tertiary centre, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 120, Pages: 513-514, ISSN: 1470-0328
Quinn SD, Vedalago J, Hamady M, et al., 2013, Pain-response and cytokine production following uterine artery embolisation and magnetic resonance guided focused ultrasound treatment for uterine fibroids, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 120, Pages: 360-360, ISSN: 1470-0328
Regan L, 2013, PREGNANCY: LESSONS LEARNT FROM MISCARRIAGE AND FETAL LOSS, Annual Meeting of the British-Society-for-Rheumatology and British-Health-Professionals-in-Rheumatology, Publisher: OXFORD UNIV PRESS, Pages: 13-13, ISSN: 1462-0324
Quinn SD, Regan L, 2012, Magnetic resonance guided focused ultrasound treatment of uterine fibroids: comparison of the Exablate 2000 to the Exablate 2100 system, International Symposium on Focused Ultrasound 2012
Poster
Lo W, Rai R, Hameed A, et al., 2012, The effect of body mass index on the outcome of pregnancy in women with recurrent miscarriage., J Family Community Med, Vol: 19, Pages: 167-171, ISSN: 1319-1683
BACKGROUND: Maternal obesity is associated with menstrual disorders, infertility and sporadic miscarriages. Recurrent miscarriage (RM) affects at least 1% of couples trying to conceive. In over 50% of cases, the cause of the loss of pregnancy remains unexplained. The aim of this study was to determine the relationship between maternal Body Mass Index (BMI) and future outcomes of pregnancy in couples with "unexplained" RM. METHODS AND RESULTS: All couples referred to the specialist recurrent miscarriage clinic at St. Mary's Hospital, London, were investigated for an underlying cause. Those with unexplained RM were eligible. Demographic and clinical data were retrieved from a computerised database and medical records. The World Health Organisation (WHO) classification of BMI was used. Univariate analysis demonstrated that BMI, maternal age, number of previous miscarriages and ethnicity were significantly associated with pregnancy outcome. Logistic regression demonstrated that maternal obesity (BMI ≥ 30 kg/m(2)) significantly increased the risk of miscarriage in couples with unexplained RM (OR 1.73; 95% CI 1.06 - 2.83). Asian women with a BMI similar to Caucasian women had a higher risk of a further miscarriage (OR 2.87, 95% CI, 1.52 - 5.39). CONCLUSIONS: Maternal obesity is an independent factor associated with an increased risk of miscarriage in couples with RM. All women with RM should have their BMI recorded at their first clinic visit. The potential effect of weight loss on the outcome of subsequent pregnancies should be assessed in future studies. The increased risk of miscarriage in Asian women needs to be explored further.
Yeung T, Regan L, 2012, Recurrent miscarriage including cervical incompetence, A Textbook of Gynecology for Less-Resourced Locations, Editors: Van Beekhuizen, Unkels, Publisher: Sapiens Publishing
Quinn SD, Disu SA, Regan L, et al., 2012, MRI Guidance of Focused Ultrasound Therapy of Uterine Fibroids: A Review of results from St Mary's Hospital, British International Congress of Obstetrics and Gynaecology
Miller A, Aziz M, Abu-Amero S, et al., 2012, Plasminogen activator inhibitor-1, polycystic ovaries and recurrent miscarriage, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 119, Pages: 128-128, ISSN: 1470-0328
Derpapas A, Ahmed S, Vijaya G, et al., 2012, Racial differences in female urethral morphology and levator hiatal dimensions: An ultrasound study, NEUROUROLOGY AND URODYNAMICS, Vol: 31, Pages: 502-507, ISSN: 0733-2467
- Author Web Link
- Cite
- Citations: 12
Quinn SD, Vedelago J, Murray C, et al., 2012, Safety profile and patient experience following Magnetic guided focused ultrasound in the treatment of uterine fibroids, Society for Gynecological Investigations
Saravelos SH, Regan L, 2012, Early pregnancy failure after ART, Pregnancy following assisted reproductive technology, Editors: Jauniaux, Rizk
Saravelos SH, Regan L, 2011, The Importance of Preconception Counseling and Early Pregnancy Monitoring, SEMINARS IN REPRODUCTIVE MEDICINE, Vol: 29, Pages: 557-568, ISSN: 1526-8004
- Author Web Link
- Cite
- Citations: 7
Salker MS, Christian M, Steel JH, et al., 2011, Deregulation of serum-and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure, Nature Medicine, Vol: 17, Pages: 1509-1513, ISSN: 1546-170X
Infertility and recurrent pregnancy loss (RPL) are prevalent but distinct causes of reproductive failure that often remain unexplained despite extensive investigations1, 2. Analysis of midsecretory endometrial samples revealed that SGK1, a kinase involved in epithelial ion transport and cell survival3, 4, 5, 6, is upregulated in unexplained infertility, most prominently in the luminal epithelium, but downregulated in the endometrium of women suffering from RPL. To determine the functional importance of these observations, we first expressed a constitutively active SGK1 mutant in the luminal epithelium of the mouse uterus. This prevented expression of certain endometrial receptivity genes, perturbed uterine fluid handling and abolished embryo implantation. By contrast, implantation was unhindered in Sgk1−/− mice, but pregnancy was often complicated by bleeding at the decidual-placental interface and fetal growth retardation and subsequent demise. Compared to wild-type mice, Sgk1−/− mice had gross impairment of pregnancy-dependent induction of genes involved in oxidative stress defenses. Relative SGK1 deficiency was also a hallmark of decidualizing stromal cells from human subjects with RPL and sensitized these cells to oxidative cell death. Thus, depending on the cellular compartment, deregulated SGK1 activity in cycling endometrium interferes with embryo implantation, leading to infertility, or predisposes to pregnancy complications by rendering the feto-maternal interface vulnerable to oxidative damage.
Quinn SD, Regan L, 2011, MRgFUS for uterine fibroids, 9th Congress of the European Society of Gynaecology
Cronly M, Behan P, Foley B, et al., 2011, Determination of eleven coccidiostats in animal feed by liquid chromatography-tandem mass spectrometry at cross contamination levels, 6th International Symposium on Hormone and Veterinary Drug Residue Analysis (VRDA), Publisher: ELSEVIER SCIENCE BV, Pages: 26-33, ISSN: 0003-2670
- Author Web Link
- Cite
- Citations: 31
Papamichael E, Aylward GW, Regan L, 2011, Obstetric opinions regarding the method of delivery in women that have had surgery for retinal detachment., JRSM Short Reports, Vol: 2, Pages: 1-24, ISSN: 2042-5333
OBJECTIVES: We sought to determine international obstetric opinions regarding the influence of a history of rhegmatogenous retinal detachment on the management of labour and to review the evidence base. DESIGN: A questionnaire containing closed questions, with pre-coded response opinions, was designed to obtain a cross-section of the obstetric opinions. SETTING: Questionnaires were distributed at the 20th European Congress of Obstetrics and Gynaecology in Lisbon, Portugal. PARTICIPANTS: One hundred questionnaires were distributed among obstetricians attending the congress and 74 agreed to participate. MAIN OUTCOME MEASURES: Participants were asked to state their preferred method of delivery in such patients and the reasons for their recommendation. Furthermore, we questioned whether there was any difference in opinions depending on generation. RESULTS: The majority of respondents (76%) would recommend assisted delivery (either Caesarean section or instrumental delivery), whereas the remaining 24% would advise normal delivery. Generation is not a factor influencing this decision. The majority (58%) based their decision to alter the management of labour on their personal opinion of standard of care. CONCLUSION: The literature shows that there is little evidence to support the belief that previous retinal surgery increases the risk of re-detachment of the retina during spontaneous vaginal delivery. This short survey shows that the majority of an international sample of obstetricians questioned does not share this viewpoint. Therefore, unnecessary interventions may be occurring in otherwise fit women with a history of retinal detachment.
Zaher S, Lyons D, Regan L, 2011, Successful <i>in vitro</i> fertilization pregnancy following magnetic resonance-guided focused ultrasound surgery for uterine fibroids, JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, Vol: 37, Pages: 370-373, ISSN: 1341-8076
- Author Web Link
- Cite
- Citations: 16
Quinn SD, Regan L, Gedroyc W, 2011, Effects of Uterine Artery Embolism and MR-Guided Focused Ultrasound Treatment on Sexual and Urinary Function in Women with Uterine Fibroids, REPRODUCTIVE SCIENCES, Vol: 18, Pages: 97A-98A, ISSN: 1933-7191
Aziz M, Rai R, Regan L, 2011, Thromboelastography and Recurrent Miscarriages - A Role for Aspirin, REPRODUCTIVE SCIENCES, Vol: 18, Pages: 114A-114A, ISSN: 1933-7191
Quinn SD, Regan L, Gedroyc W, 2011, Demographics and Outcomes of Women Undergoing MR-Guided Focused Ultrasound Treatment of Their Uterine Fibroids, REPRODUCTIVE SCIENCES, Vol: 18, Pages: 98A-98A, ISSN: 1933-7191
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.