Summary
We are interested in how the molecular machinery of the cell assembles, functions, and evolves. To tackle this problem we use electron cryo-tomography, a technique that enables us to visualize this machinery inside living cells -- to resolutions capable of discerning individual proteins.
I am co-director of the Department of Life Science's MRes in Structural Molecular Biology. Please click here for more details.
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Publications
Journals
Huang X, Torre I, Chiappi M, et al., 2023, Cryo-electron tomography of intact cardiac muscle reveals myosin binding protein-C linking myosin and actin filaments., J Muscle Res Cell Motil
Kaplan M, Oikonomou CM, Wood CR, et al., 2022, Discovery of a Novel Inner Membrane-Associated Bacterial Structure Related to the Flagellar Type III Secretion System, Journal of Bacteriology, Vol:204, ISSN:0021-9193
Ortega D, Beeby M, 2022, How did the archaellum get its rotation?, Frontiers in Microbiology, Vol:12, ISSN:1664-302X, Pages:1-6
Kaplan M, Oikonomou CM, Wood CR, et al., 2022, Novel transient cytoplasmic rings stabilize assembling bacterial flagellar motors, Embo Journal, Vol:41, ISSN:0261-4189
Mandela E, Stubenrauch CJ, Ryoo D, et al., 2022, Adaptation of the periplasm to maintain spatial constraints essential for cell envelope processes and cell viability, Elife, Vol:11, ISSN:2050-084X