We are interested in how the molecular machinery of the cell assembles, functions, and evolves. To tackle this problem we use electron cryo-tomography, a technique that enables us to visualize this machinery inside living cells -- to resolutions capable of discerning individual proteins.
I am co-director of the Department of Life Science's MRes in Structural Molecular Biology. Please click here for more details.
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Beeby M, 2020, Toward Organism-scale Structural Biology: S-layer Reined in by Bacterial LPS., Trends Biochem Sci, Vol:45, ISSN:0968-0004, Pages:549-551
et al., In situ structure of the Caulobacter crescentus flagellar motor and visualization of binding of a CheY-homolog, Molecular Microbiology, ISSN:0950-382X
et al., 2020, The Brownian and Flow-Driven Rotational Dynamics of a Multicomponent DNA Origami-Based Rotor, Small, Vol:16, ISSN:1613-6810
et al., 2020, Bacterial flagellar motor PL-ring disassembly subcomplexes are widespread and ancient, Proceedings of the National Academy of Sciences of the United States of America, Vol:117, ISSN:0027-8424, Pages:8941-8947
et al., 2020, Propulsive nanomachines: the convergent evolution of archaella, flagella, and cilia, Fems Microbiology Reviews, ISSN:0168-6445