We are interested in how the molecular machinery of the cell assembles, functions, and evolves. To tackle this problem we use electron cryo-tomography, a technique that enables us to visualize this machinery inside living cells -- to resolutions capable of discerning individual proteins.
I am co-director of the Department of Life Science's MRes in Structural Molecular Biology. Please click here for more details.
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et al., 2021, Structure of the cytoplasmic domain of SctV (SsaV) from the Salmonella SPI-2 injectisome and implications for a pH sensing mechanism, Journal of Structural Biology, Vol:213, ISSN:1047-8477
et al., 2021, The 'jack-of-all-trades' flagellum from Salmonella and E. coli was horizontally acquired from an ancestral beta-proteobacterium, Frontiers in Microbiology, Vol:12, ISSN:1664-302X
et al., 2021, Analysis of Cell-Cell Bridges in Haloferax volcanii Using Electron Cryo-Tomography Reveal a Continuous Cytoplasm and S-Layer, Frontiers in Microbiology, Vol:11, ISSN:1664-302X
et al., 2020, CryoEM of bacterial secretion systems: A primer for microbiologists, Molecular Microbiology, Vol:115, ISSN:0950-382X, Pages:366-382
et al., 2020, Inter-membrane association of the Sec and BAM translocons for bacterial outer-membrane biogenesis, Elife, Vol:9, ISSN:2050-084X