Summary
We are interested in how the molecular machinery of the cell assembles, functions, and evolves. To tackle this problem we use electron cryo-tomography, a technique that enables us to visualize this machinery inside living cells -- to resolutions capable of discerning individual proteins.
I am co-director of the Department of Life Science's MRes in Structural Molecular Biology. Please click here for more details.
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Publications
Journals
Ahmadi Y, Umrekar TR, Mutter N, et al., 2024, DNA origami-enhanced binding of aptamers to Staphylococcus aureus cells, Biosensors and Bioelectronics: X, Vol:16
Huang X, Torre I, Chiappi M, et al., 2023, Cryo-electron tomography of intact cardiac muscle reveals myosin binding protein-C linking myosin and actin filaments, Journal of Muscle Research and Cell Motility, Vol:44, ISSN:0142-4319, Pages:165-178
Wilkinson MD, Ferreira JL, Beeby M, et al., 2022, The malaria parasite chaperonin containing TCP-1 (CCT) complex: Data integration with other CCT proteomes, Frontiers in Molecular Biosciences, Vol:9
Kaplan M, Oikonomou CM, Wood CR, et al., 2022, Discovery of a Novel Inner Membrane-Associated Bacterial Structure Related to the Flagellar Type III Secretion System, Journal of Bacteriology, Vol:204, ISSN:0021-9193
Kaplan M, Oikonomou CM, Wood CR, et al., 2022, Novel transient cytoplasmic rings stabilize assembling bacterial flagellar motors, Embo Journal, Vol:41, ISSN:0261-4189