Imperial College London
Alternate

ProfessorMarinaBotto

Faculty of Medicine, Department of Immunology and Inflammation

Head of Department, Director of Bioservices
 
 
 
//

Contact

 

+44 (0)20 3313 2316m.botto Website

 
 
//

Assistant

 

Miss Claudia Rocchi +44 (0)20 3313 2315

 
//

Location

 

9N10Commonwealth BuildingHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Botto:1996:10.1046/j.1365-2249.1996.33740.x,
author = {Botto, M and Theodoridis, E and Thompson, EM and Beynon, HL and Briggs, D and Isenberg, DA and Walport, MJ and Davies, KA},
doi = {10.1046/j.1365-2249.1996.33740.x},
journal = {Clin Exp Immunol},
pages = {264--268},
title = {Fc gamma RIIa polymorphism in systemic lupus erythematosus (SLE): no association with disease.},
url = {http://dx.doi.org/10.1046/j.1365-2249.1996.33740.x},
volume = {104},
year = {1996}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - An allotypic variant of Fc gamma RIIa, Fc gamma RIIa-HR (Fc gamma RIIa-R131), has been shown in vitro to reduce the capacity of phagocytic cells to bind and internalize IgG-containing immune complexes. Our aim was to determine whether this allotypic variant was associated with susceptibility to SLE and the development of lupus nephritis, as previous studies have suggested. Fc gamma RIIA genotype analysis was performed by amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) in 215 Caucasoid, 70 Afro-Caribbean, and 46 Chinese patients with SLE, and in 259,77 and 49 ethnically matched controls, respectively. Distribution of Fc gamma RIIa genotypes between the patients and ethnically matched controls was not significantly different in the three populations studied. No association between the Fc gamma RIIa-HR allotype and nephritis was found. Our results suggest that the Fc gamma RIIa-HR allotype is not a major factor predisposing to the development of SLE, or to lupus nephritis.
AU  - Botto,M
AU  - Theodoridis,E
AU  - Thompson,EM
AU  - Beynon,HL
AU  - Briggs,D
AU  - Isenberg,DA
AU  - Walport,MJ
AU  - Davies,KA
DO  - 10.1046/j.1365-2249.1996.33740.x
EP  - 268
PY  - 1996///
SN  - 0009-9104
SP  - 264
TI  - Fc gamma RIIa polymorphism in systemic lupus erythematosus (SLE): no association with disease.
T2  - Clin Exp Immunol
UR  - http://dx.doi.org/10.1046/j.1365-2249.1996.33740.x
UR  - https://www.ncbi.nlm.nih.gov/pubmed/8625518
VL  - 104
ER  -
Download