Imperial College London
Alternate

ProfessorMartinCowie

Faculty of Medicine, National Heart & Lung Institute

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7351 8856m.cowie

 
 
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Assistant

 

Mr Jacob Chapman +44 (0)20 7351 8856

 
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Location

 

Chelsea WingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cowie:1997,
author = {Cowie, MR and Wood, DA and Coats, A and Thompson, SG and Poole-Wilson, PA and Sutton, GC},
journal = {Heart},
title = {Incidence and aetiology of heart failure in the general population},
volume = {77},
year = {1997}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The contemporary incidence of heart failure in the UK is not known. A prospective survey of incident cases of heart failure presenting to 81 general practitioners and a district general hospital serving a population of 151 000 was conducted over 15 months. Cases were identified from hospital admissions and through a daily rapid access heart failure clinic to which GP's referred all new cases of suspected heart failure. Following a standardised interview, physical examination, ECG, CXR and echocardiogram all cases were reviewed by a panel of 3 cardiologists who determined whether the clinical case definition of heart failure was met and the aetiology. 171 incident cases of heart failure were identified (94M:77F) with no case aged under 35 years. Thirty five cases (20%) were identified from 122 referrals to the clinic, the remainder being acute hospital admissions. The incidence increased dramatically with age from 0.2 per 1000 population per annum in those aged 35-44 years to 11.6 in those aged 85 years or over and was higher in males than females (comparative incidence ratio 1.9 [95% CI 1.5-2.4] p<0.0001). The median age at presentation was 76 years. Aetiologies were ischaemic heart disease (36%), hypertension (15%), valve disease (6%), other (7%) but in 36% of cases the aetiology was unknown. Randomised controlled trials of heart failure are conducted in highly selected hospital cases with a strong bias towards younger patients and those with coronary artery disease as the aetiology. However, in the general population new cases of heart failure largely arise in the elderly and in over a third of cases the aetiology cannot be determined from non-invasive investigation. These findings have important implications for the investigation and management of new cases of heart failure in the general population.
AU  - Cowie,MR
AU  - Wood,DA
AU  - Coats,A
AU  - Thompson,SG
AU  - Poole-Wilson,PA
AU  - Sutton,GC
PY  - 1997///
SN  - 1355-6037
TI  - Incidence and aetiology of heart failure in the general population
T2  - Heart
VL  - 77
ER  -
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