Publications

BibTex format

@article{Gunter:2011,
author = {Gunter, MJ and Cross, AJ and Huang, WY and Stanczyk, FZ and Purdue, M and Xue, X and Schoen, R and Limburg, PJ and Schatzkin, A and Sinha, R and Hayes, RB},
journal = {Cancer Epidemiology Biomarkers and Prevention},
pages = {537--544},
title = {A prospective evaluation of C-reactive protein levels and colorectal adenoma development},
volume = {3},
year = {2011}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND:Inflammation is hypothesized to play a role in colorectal tumorigenesis. Circulating levels of C-reactive protein (CRP), a serologic marker of the inflammatory response, have been positively associated with colorectal cancer development in some studies; however, there are limited data on the relation of CRP with colorectal adenomas, established precursors of colorectal cancer.METHODS:A nested case-control investigation of CRP levels and incident colorectal adenoma was conducted in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, a randomized trial of 154,942 individuals designed to test the efficacy of flexible sigmoidoscopy on colorectal cancer mortality when performed once, and then repeated 3 to 5 years later. Serum CRP levels were measured in baseline blood specimens from participants who were free of polyps in the left-sided colorectum at the baseline screening procedure, but who were found at the subsequent screen to have at least one colorectal adenoma (n=356), and in a set of polyp-free, frequency-matched controls (n=396).RESULTS:In a multivariable logistic regression model that included established colorectal adenoma risk factors, a 1-unit increase in log CRP level was associated with a 15% reduction in risk of developing colorectal adenoma (OR=0.85, 95% CI, 0.75-0.98, Ptrend=0.01). This association did not differ according to body size, smoking behavior, gender, use of nonsteroidal antiinflammatory drugs, or adenoma location.CONCLUSIONS:High circulating CRP levels may be protective against colorectal adenoma development.IMPACT:Though at contrast with mechanistic data on inflammation and colorectal tumorigenesis, this finding is not inconsistent with prior results on CRP and colorectal adenoma and warrants further investigation.
AU  - Gunter,MJ
AU  - Cross,AJ
AU  - Huang,WY
AU  - Stanczyk,FZ
AU  - Purdue,M
AU  - Xue,X
AU  - Schoen,R
AU  - Limburg,PJ
AU  - Schatzkin,A
AU  - Sinha,R
AU  - Hayes,RB
EP  - 544
PY  - 2011///
SP  - 537
TI  - A prospective evaluation of C-reactive protein levels and colorectal adenoma development
T2  - Cancer Epidemiology Biomarkers and Prevention
VL  - 3
ER  -

Download

ProfessorMarcGunter

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)