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@article{Dimitrakopoulos:2020:10.1158/0008-5472.can-19-3578,
author = {Dimitrakopoulos, F-ID and Kottorou, AE and Kalofonou, M and Kalofonos, HP},
doi = {10.1158/0008-5472.can-19-3578},
journal = {Cancer Research},
pages = {4025--4036},
title = {The fire within: NF-κB involvement in non–small cell lung cancer},
url = {http://dx.doi.org/10.1158/0008-5472.can-19-3578},
volume = {80},
year = {2020}
}

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TY  - JOUR
AB  - Thirty-four years since its discovery, NF-κB remains a transcription factor with great potential for cancer therapy. However, NF-κB–targeted therapies have yet to find a way to be clinically translatable. Here, we focus exclusively on the role of NF-κB in non-small cell lung cancer (NSCLC) and discuss its contributing effect on cancer hallmarks such as inflammation, proliferation, survival, apoptosis, angiogenesis, epithelial–mesenchymal transition, metastasis, stemness, metabolism, and therapy resistance. In addition, we present our current knowledge of the clinical significance of NF-κB and its involvement in the treatment of patients with NSCLC with chemotherapy, targeted therapies, and immunotherapy.
AU  - Dimitrakopoulos,F-ID
AU  - Kottorou,AE
AU  - Kalofonou,M
AU  - Kalofonos,HP
DO  - 10.1158/0008-5472.can-19-3578
EP  - 4036
PY  - 2020///
SN  - 0008-5472
SP  - 4025
TI  - The fire within: NF-κB involvement in non–small cell lung cancer
T2  - Cancer Research
UR  - http://dx.doi.org/10.1158/0008-5472.can-19-3578
UR  - https://cancerres.aacrjournals.org/content/80/19/4025
VL  - 80
ER  -

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