Imperial College London
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DrMelpomeniKalofonou

Faculty of Engineering, Department of Electrical and Electronic Engineering

Research Fellow in Cancer Technology
 
 
 
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Contact

 

+44 (0)20 7594 1594m.kalofonou Website CV

 
 
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Location

 

B420C - Centre for Bio-Inspired Technology (CBIT)Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dimitrakopoulos:2015:10.1016/j.lungcan.2015.06.006,
author = {Dimitrakopoulos, F-ID and Antonacopoulou, AG and Kottorou, A and Marousi, S and Koukourikou, I and Kalofonou, M and Panagopoulos, N and Scopa, C and Dougenis, D and Papadaki, H and Papavassiliou, AG and Kalofonos, HP},
doi = {10.1016/j.lungcan.2015.06.006},
journal = {Lung Cancer},
pages = {311--319},
title = {Variant of BCL3 gene is strongly associated with five-year survival of non-small-cell lung cancer patients},
url = {http://dx.doi.org/10.1016/j.lungcan.2015.06.006},
volume = {89},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ObjectivesBCL3, a known atypical IκB family member, has been documented to be upregulated in hematological malignancies and in some solid tumors, functioning as a crucial player in tumor development. Recently, rs8100239, a tag-Single Nucleotide Polymorphism (SNP) in BCL3 (T > A) has been identified, but there are no data regarding its involvement in non-small-cell lung cancer (NSCLC) initiation and progression.Materials and methodsTo study the possible association of BCL3 with NSCLC, 268 patients and 279 healthy controls were genotyped for rs8100239. Moreover, BCL3 protein expression was also investigated in 112 NSCLC cases through an immunohistochemical analysis.ResultsNSCLC patients with AA genotype displayed significantly worse prognosis compared to T allele carriers (P < 0.001), who had less frequent intermediate nuclear BCL3 expression (P = 0.042). In addition, overexpression of BCL3 was detected in tumor specimens, compared to normal tissue (P < 0.001). Furthermore, BCL3 protein levels were associated with five-year survival (P  =0.039), maximum diameter of lesion (P = 0.012), grade (P = 0.002) and relapse frequency (P = 0.041).ConclusionsThe present study is the first to show a relationship between the genetic variation rs8100239 of BCL3 and cancer patients’ survival. It also represents the first quantitative evaluation of BCL3 expression in NSCLC. Our findings indicate that rs8100239 may be considered as a novel prognostic indicator, demonstrating also the overexpression of BCL3 protein in NSCLC and implicating this pivotal molecule in the pathogenesis of NSCLC.
AU  - Dimitrakopoulos,F-ID
AU  - Antonacopoulou,AG
AU  - Kottorou,A
AU  - Marousi,S
AU  - Koukourikou,I
AU  - Kalofonou,M
AU  - Panagopoulos,N
AU  - Scopa,C
AU  - Dougenis,D
AU  - Papadaki,H
AU  - Papavassiliou,AG
AU  - Kalofonos,HP
DO  - 10.1016/j.lungcan.2015.06.006
EP  - 319
PY  - 2015///
SN  - 0169-5002
SP  - 311
TI  - Variant of BCL3 gene is strongly associated with five-year survival of non-small-cell lung cancer patients
T2  - Lung Cancer
UR  - http://dx.doi.org/10.1016/j.lungcan.2015.06.006
UR  - http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=21&SID=C6MQWHF6Hot727MmQai&page=1&doc=6
VL  - 89
ER  -
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