Publications
2089 results found
Yacoub MH, Bonow R, Olivotto I, 2012, Editors' page., Glob Cardiol Sci Pract, Vol: 2012, ISSN: 2305-7823
Salhiyyah K, Yacoub MH, Chester AH, 2011, Cellular Mechanisms in Mitral Valve Disease, JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, Vol: 4, Pages: 702-709, ISSN: 1937-5387
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- Citations: 15
El-Hamamsy I, Ibrahim M, Stevens L-M, et al., 2011, Early and long-term results of reoperative total aortic root replacement with reimplantation of the coronary arteries, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Vol: 142, Pages: 1473-1477, ISSN: 0022-5223
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- Citations: 13
Navaratnarajah M, Ibrahim M, Siedlecka U, et al., 2011, Ivabradine Reduces Interstitial Fibrosis and Enhances the Recovery of Cardiomyocyte Excitation-Contraction Coupling Produced by Mechanical Unloading, CIRCULATION, Vol: 124, ISSN: 0009-7322
Siedlecka U, Navaratnarajah M, Gandhi A, et al., 2011, Clenbuterol Affects Cardiomyocyte Contractility Via A β2-Adrenoceptor Independent Pathway, CIRCULATION, Vol: 124, ISSN: 0009-7322
Ibrahim M, Terracciano CM, Yacoub MH, 2011, Bridge to Recovery: What Remains to be Discovered?, CARDIOLOGY CLINICS, Vol: 29, Pages: 531-+, ISSN: 0733-8651
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- Citations: 7
Mocumbi AO, Carrilho C, Sarathchandra P, et al., 2011, Echocardiography accurately assesses the pathological abnormalities of chronic endomyocardial fibrosis., Int J Cardiovasc Imaging, Vol: 27, Pages: 955-964
Endomyocardial fibrosis (EMF) is a cardiomyopathy with high prevalence in Sub-Saharan Africa with unclear etiology, pathogenesis and natural history. Most pathological abnormalities can potentially be diagnosed by echocardiography allowing surgery in some cases. With increasing availability of echocardiography in endemic areas for EMF we designed a study aiming at assessing its accuracy in defining EMF structural abnormalities pre-operatively, and describe pathological findings through detailed intraoperative examination and evaluation of histopathological changes in tissue obtained from excisional biopsies. Transthoracic echocardiography was performed pre-operatively to 29 patients with chronic severe EMF. All patients were submitted to excisional endomyocardial biopsies during surgery and careful standardized intra-operative evaluation was also done. Surgical and histopathological findings were compared to those obtained by echocardiography. Of the 29 patients studied, 16 had moderate lesions while 13 had severe disease. Their mean age was 12 (±4.6) years and 17 were males. All but one patient were in NYHA functional class III or IV at time of surgery. All patients had severe atrioventricular valve regurgitation with valves considered suitable for repair. We evaluated tissue from 25 left ventricles and 12 right ventricles. Endocardial thickening was the most prominent abnormality due to deposition of hyaline and cellular collagen underneath a layer of apparently normal endocardial endothelial cells. The mean endocardial thickness was 2,541 ± 1,707 μm. There was high agreement between echocardiographic and intraoperative findings, with the findings coinciding completely in 24 patients. Severe EMF assessed by echocardiography was associated with intense endocardial fibrosis on histology. In contrast, the presence of inflammation in peripheral blood was not associated with tissue inflammation. Structural abnormalities of chronic severe EMF are accura
Krishnamoorthy N, Yacoub MH, Yaliraki SN, 2011, A computational modeling approach for enhancing self-assembly and biofunctionalisation of collagen biomimetic peptides, BIOMATERIALS, Vol: 32, Pages: 7275-7285, ISSN: 0142-9612
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- Citations: 26
Ibrahim M, Gorelik J, Yacoub MH, et al., 2011, The structure and function of cardiac t-tubules in health and disease, PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 278, Pages: 2714-2723, ISSN: 0962-8452
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- Citations: 97
Camelliti P, Abou Al-Saud S, Smolenski RT, et al., 2011, Adult human heart slices are a multicellular system suitable for electrophysiological and pharmacological studies, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Vol: 51, Pages: 390-398, ISSN: 0022-2828
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- Citations: 61
Jakovljevic DG, Birks EJ, George RS, et al., 2011, Relationship between peak cardiac pumping capability and selected exercise-derived prognostic indicators in patients treated with left ventricular assist devices, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 13, Pages: 992-999, ISSN: 1388-9842
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- Citations: 19
Badran H, Elnoamany M, Abdo W, et al., 2011, Aortic biomechanics in hypertrophic cardiomyopathy, EUROPEAN HEART JOURNAL, Vol: 32, Pages: 590-591, ISSN: 0195-668X
Badran H, Elnoamany M, Soltan G, et al., 2011, Relationship of QT prolongation to mechanical dyssynchrony in hypertrophic cardiomyopathy, EUROPEAN HEART JOURNAL, Vol: 32, Pages: 592-593, ISSN: 0195-668X
Mocumbi AO, Songane M, Salomao C, et al., 2011, Lack of Evidence of Myocardial Damage in Children with <i>Plasmodium falciparum</i> Severe and Complicated Malaria from an Endemic Area for Endomyocardial Fibrosis, JOURNAL OF TROPICAL PEDIATRICS, Vol: 57, Pages: 312-314, ISSN: 0142-6338
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- Citations: 9
Yacoub MH, Terracciano CM, 2011, Bridge to Recovery and the Search for Decision Nodes, CIRCULATION-HEART FAILURE, Vol: 4, Pages: 393-+, ISSN: 1941-3289
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- Citations: 8
Taegtmeyer AB, Breen JB, Smith J, et al., 2011, Effect of ABCB1 Genotype on Pre- and Post-Cardiac Transplantation Plasma Lipid Concentrations, JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, Vol: 4, Pages: 304-312, ISSN: 1937-5387
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- Citations: 13
Bertazzo S, Cloyd KL, Gentleman E, et al., 2011, NANO- AND MICRO-STRUCTURE OF CALCIFICATION IN HUMAN AORTIC VALVE, AORTA AND CORONARY WALL, 79th Congress of the European-Atherosclerosis-Society (EAS), Publisher: ELSEVIER IRELAND LTD, Pages: 62-62, ISSN: 1567-5688
Treasure T, Hasan A, Yacoub M, 2011, Is there a risk in avoiding risk for younger patients with aortic valve disease?, BMJ, Vol: 342
Yacoub S, Kotit S, Yacoub MH, 2011, Disease appearance and evolution against a background of climate change and reduced resources, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, Vol: 369, Pages: 1719-1729, ISSN: 1364-503X
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- Citations: 19
Yacoub MH, Terracciano CM, 2011, The Holy Grail of LVAD-induced reversal of severe chronic heart failure: the need for integration, EUROPEAN HEART JOURNAL, Vol: 32, Pages: 1052-1054, ISSN: 0195-668X
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- Citations: 6
Maron BJ, Yacoub M, Dearani JA, 2011, Controversies in cardiovascular medicine. Benefits of surgery in obstructive hypertrophic cardiomyopathy: bring septal myectomy back for European patients., Eur Heart J, Vol: 32, Pages: 1055-1058
Hypertrophic cardiomyopathy (HCM), a heterogeneous genetic heart disease with global distribution, is an important cause of heart failure disability at any age. For 50 years, surgical septal myectomy has been the preferred and primary treatment strategy for most HCM patients with progressive, drug refractory functional limitation due to left ventricular (LV) outflow tract obstruction. With very low surgical mortality at experienced centres, septal myectomy reliably abolishes impedance to LV outflow and heart failure-related symptoms, restores quality of life, and importantly is associated with long-term survival similar to that in the general population. Nevertheless, alternatives to surgical management are necessary for selected HCM patients. For example, after a brief flirtation with dual-chamber pacing 20 years ago, percutaneous alcohol septal ablation has garnered a large measure of enthusiasm and a dedicated following in the interventional cardiology community, achieving benefits for patients, paradoxically, by virtue of producing a transmural myocardial infarct. However, an unintended consequence has been the virtual obliteration of the surgical option for HCM patients in Europe, where several robust myectomy programmes once existed. Therefore, clear differences are now evident internationally regarding management strategies for symptomatic obstructive HCM. The surgical option is now unavailable to many patients based solely on geography, including some who would likely benefit more substantially from surgical myectomy than from catheter-based alcohol ablation. It is our aspiration that this discussion will generate reconsideration and resurgence of interest in surgical septal myectomy as a treatment option for severely symptomatic obstructive HCM patients within Europe.
Navaratnarajah M, van Doorn C, Siedlecka U, et al., 2011, Ivabradine Enhances the Sarcoplasmic Reticulum Calcium Content in Ventricular Myocytes during Mechanical Unloading in a Rodent Model of Heart Failure, 31st Annual Meeting and Scientific Sessions on International-Society-for-Heart-and-Lung-Transplantation, Publisher: ELSEVIER SCIENCE INC, Pages: S188-S188, ISSN: 1053-2498
Aaronson KD, Pagani FD, Maybaum SW, et al., 2011, Combination Therapy with Pulsatile Left Ventricular Assist Device, Heart Failure Medication and Clenbuterol in Chronic Heart Failure: Results from HARPS, 31st Annual Meeting and Scientific Sessions on International-Society-for-Heart-and-Lung-Transplantation, Publisher: ELSEVIER SCIENCE INC, Pages: S8-S9, ISSN: 1053-2498
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- Citations: 11
El-Hamamsy I, Ibrahim M, Yacoub MH, 2011, 30-Year Outcome of Anatomic Correction of Anomalous Origin of the Left Coronary Artery From the Pulmonary Artery, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 57, Pages: 1493-1493, ISSN: 0735-1097
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- Citations: 1
Drakos SG, Terrovitis JV, Nanas JN, et al., 2011, Reverse Electrophysiologic Remodeling After Cardiac Mechanical Unloading for End-Stage Nonischemic Cardiomyopathy, ANNALS OF THORACIC SURGERY, Vol: 91, Pages: 764-769, ISSN: 0003-4975
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- Citations: 26
Birks EJ, George RS, Hedger M, et al., 2011, Reversal of Severe Heart Failure With a Continuous-Flow Left Ventricular Assist Device and Pharmacological Therapy A Prospective Study, CIRCULATION, Vol: 123, Pages: 381-U299, ISSN: 0009-7322
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- Citations: 282
Fukushima S, Campbell NG, Coppen SR, et al., 2011, Quantitative assessment of initial retention of bone marrow mononuclear cells injected into the coronary arteries, JOURNAL OF HEART AND LUNG TRANSPLANTATION, Vol: 30, Pages: 227-233, ISSN: 1053-2498
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- Citations: 11
Chester AH, Yacoub MH, Taylor PM, 2011, Heart Valve Tissue Engineering, Studies in Mechanobiology, Tissue Engineering and Biomaterials, Pages: 243-266
Extensive research into the structural and functional properties of heart valves shows that they perform sophisticated functions which depend on their unique properties at the tissue, cellular and molecular levels. Furthermore, there is accumulating evidence that these complex functional properties translate into clinically relevant end points to all patients undergoing valve replacement surgery, particularly in children and young adults. Tissue engineering a heart valve offers the potential of replicating these functions and benefits via the production of a ‘living’ valve that resembles the shape and function of the native valve. This chapter will review the biology of heart valves and discuss strategies and advances that have been made towards the goal of producing a living tissue engineered heart valve.
Colazzo F, Sarathchandra P, Smolenski RT, et al., 2011, Extracellular matrix production by adipose-derived stem cells: Implications for heart valve tissue engineering, BIOMATERIALS, Vol: 32, Pages: 119-127, ISSN: 0142-9612
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- Citations: 68
Lewinsohn AD, Anssari-Benham A, Lee DA, et al., 2011, Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment, PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE, Vol: 225, Pages: 821-830, ISSN: 0954-4119
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- Citations: 23
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