Publications
2089 results found
Bowles CT, New SEP, van Loon R, et al., 2010, Hydrodynamic Evaluation of a Bioreactor for Tissue Engineering Heart Valves, Cardiovascular Engineering and Technology, Vol: 1, Pages: 10-17, ISSN: 1869-408X
The principal objective was to develop an autoclavable pulsatile bioreactor capable of subjecting disc-shaped or trileaflet valve tissue constructs to prescribed, reproducible hydrodynamic profiles. The pump actuator consisted of: a computer-controlled stepper motor and a lead-screw attached to the piston of a water filled cylinder which was connected to the outer chamber of a pulsatile sac ventricular assist device with tilting disc valves. Reciprocation of the piston caused circulation of tissue culture medium in a bioreactor comprising a vented low-pressure reservoir and a sealed windkessel (air spring) and flow resistor to simulate arterial compliance and systemic vascular resistance, respectively. Disc-shaped tissue constructs could be interposed between the windkessel and the reservoir to allow them to be subjected to controllable pressure waveforms. Alternatively, the outflow valve of the pulsatile pump could be replaced with a valve-like tissue construct. Evaluation of the hydrodynamic capabilities of the system showed that for both the disc-shaped and the valve constructs a wide range of stable hydrodynamic profiles could be specified and attained, free of pressure transients and valve closure-associated pressure oscillations. Pressure rise within the windkessel was primarily determined by pump driving parameters whereas the time constant of the decay of pressure was determined by the product of windkessel compliance (C) and outflow resistance (R) of the windkessel. In conclusion, the novel bioreactor has a number of characteristics which may be valuable for the development of tissue engineered heart valves. © 2010 Biomedical Engineering Society.
Dib N, Menasche P, Bartunek JJ, et al., 2010, Recommendations for successful training on methods of delivery of biologics for cardiac regeneration: a report of the International Society for Cardiovascular Translational Research., JACC Cardiovasc Interv, Vol: 3, Pages: 265-275
The field of myocardial regeneration (angiogenesis and myogenesis) might prove to play an important role in the future management of cardiovascular disease. Stem cells are currently undergoing testing in Phase I and Phase II clinical trials. Methods of delivery will affect the outcome of such therapies, perhaps significantly. This document provides suggested guidance in 4 methods of delivery: endocardial, intracoronary, coronary sinus, and epicardial.
Smolenski RT, Osman L, Yuen AH, et al., 2010, Effects and catabolism of ATP in heart valve leaflets, PURINERGIC SIGNALLING, Vol: 6, Pages: 138-138, ISSN: 1573-9538
George RS, Yacoub MH, Cheetham A, et al., 2010, LVAD Support Results in a Significant Improvement in the Myocardial Sympathetic Nervous System, as Assessed by <SUP>123</SUP>I-Metaiodobenzylguanidine (<SUP>123</SUP>I-MIBG), Independent of Ventricular Function, 30th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation, Publisher: ELSEVIER SCIENCE INC, Pages: S180-S180, ISSN: 1053-2498
George RS, Yacoub MH, Lister H, et al., 2010, The Effects of Clenbuterol on the Left Ventricular Wall Thickness and Function in Patients Recovered on Left Ventricular Assist Device (LVAD), 30th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation, Publisher: ELSEVIER SCIENCE INC, Pages: S182-S182, ISSN: 1053-2498
Beale J, George RS, Smith J, et al., 2010, Myocardial Recovery Is Associated with Low Levels of Circulating MMP8 at LVAD Implantation, 30th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation, Publisher: ELSEVIER SCIENCE INC, Pages: S65-S66, ISSN: 1053-2498
Birks EJ, George RS, Noor M, et al., 2010, Long Term Outcome of Bridge to Recovery Versus Bridge to Transplantation, 30th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation, Publisher: ELSEVIER SCIENCE INC, Pages: S176-S177, ISSN: 1053-2498
Chambers JC, Zhao J, Terracciano CMN, et al., 2010, Genetic variation in <i>SCN10A</i> influences cardiac conduction, NATURE GENETICS, Vol: 42, Pages: 149-U80, ISSN: 1061-4036
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- Citations: 204
Birks EJ, George RS, Hedger M, et al., 2010, Myocardial Recovery from Advanced Heart Failure Using the Heartmate II LVAD Combined with Drug Therapy: Results from a Prospective Study, 30th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation, Publisher: ELSEVIER SCIENCE INC, Pages: S66-S66, ISSN: 1053-2498
El-Hamamsy I, Clark L, Stevens LM, et al., 2010, Late Outcomes Following Freestyle Versus Homograft Aortic Root Replacement Results From a Prospective Randomized Trial, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 55, Pages: 368-376, ISSN: 0735-1097
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- Citations: 91
Taegtmeyer AB, Breen JB, Smith J, et al., 2010, ATP-Binding Cassette Subfamily B Member 1 Polymorphisms Do Not Determine Cyclosporin Exposure, Acute Rejection or Nephrotoxicity After Heart Transplantation, TRANSPLANTATION, Vol: 89, Pages: 75-82, ISSN: 0041-1337
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- Citations: 12
El-Hamamsy I, Chester AH, Yacoub MH, 2010, Cellular regulation of the structure and function of aortic valves, Journal of Advanced Research, Vol: 1, Pages: 5-12, ISSN: 2090-1232
The aortic valve was long considered a passive structure that opens and closes in response to changes in transvalvular pressure. Recent evidence suggests that the aortic valve performs highly sophisticated functions as a result of its unique microscopic structure. These functions allow it to adapt to its hemodynamic and mechanical environment. Understanding the cellular and molecular mechanisms involved in normal valve physiology is essential to elucidate the mechanisms behind valve disease. We here review the structure and developmental biology of aortic valves; we examine the role of its cellular parts in regulating its function and describe potential pathophysiological and clinical implications. © 2009 University of Cairo.
Drakos SG, Athanasoulis T, Malliaras KG, et al., 2010, Myocardial Sympathetic Innervation and Long-Term Left Ventricular Mechanical Unloading, JACC-CARDIOVASCULAR IMAGING, Vol: 3, Pages: 64-70, ISSN: 1936-878X
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- Citations: 63
Borkowski T, Slominska EM, Orlewska C, et al., 2010, Protection of Mouse Heart Against Hypoxic Damage by AMP Deaminase Inhibition, NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, Vol: 29, Pages: 449-452, ISSN: 1525-7770
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- Citations: 5
Borkowski T, Slominska EM, Orlewska C, et al., 2010, Biological Efficiency of AMP Deaminase Inhibitor: 3-[2-(3-CARBOXY-4-BROMO-5,6,7,8-Tetrahydronaphthyl)Ethyl]-3,6,7,8-Tetrahydroimidazo[4,5]-[1,3]Diazepin-8-OL, NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, Vol: 29, Pages: 457-460, ISSN: 1525-7770
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- Citations: 2
Terracciano CM, Miller LW, Yacoub MH, 2010, Contemporary Use of Ventricular Assist Devices, ANNUAL REVIEW OF MEDICINE, Vol: 61, Pages: 255-270, ISSN: 0066-4219
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- Citations: 33
Wang L, Lekadir K, El-Hamamsy I, et al., 2010, Subject Specific Shape Modeling with Incremental Mixture Models, 5th International Workshop on Medical Imaging and Augmented Reality, Publisher: SPRINGER-VERLAG BERLIN, Pages: 21-+, ISSN: 0302-9743
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- Citations: 5
Klieverik LMA, Yacoub MH, Edwards S, et al., 2009, Surgical Treatment of Active Native Aortic Valve Endocarditis With Allografts and Mechanical Prostheses, ANNALS OF THORACIC SURGERY, Vol: 88, Pages: 1814-1821, ISSN: 0003-4975
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- Citations: 60
El-Hamamsy I, Yacoub MH, 2009, Cellular and molecular mechanisms of thoracic aortic aneurysms, NATURE REVIEWS CARDIOLOGY, Vol: 6, Pages: 771-786, ISSN: 1759-5002
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- Citations: 220
Yacoub MH, El-Hamamsy I, Said K, et al., 2009, The Left Ventricular Outflow in Hypertrophic Cardiomyopathy: From Structure to Function, JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, Vol: 2, Pages: 510-517, ISSN: 1937-5387
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- Citations: 8
Nistri S, Olivotto I, Girolami F, et al., 2009, Looking for Hypertrophic Cardiomyopathy in the Community: Why Is It Important?, JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, Vol: 2, Pages: 392-397, ISSN: 1937-5387
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- Citations: 7
Olivotto I, Girolami F, Nistri S, et al., 2009, The Many Faces of Hypertrophic Cardiomyopathy: From Developmental Biology to Clinical Practice, JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, Vol: 2, Pages: 349-367, ISSN: 1937-5387
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- Citations: 51
El-Hamamsy I, Clark LA, Stevens LM, et al., 2009, Late Outcomes Following Freestyle versus Homograft Aortic Root Replacement: Results From a Prospective Randomized Trial, 82nd Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S848-S849, ISSN: 0009-7322
El-Hamamsy I, Lekadir K, Merrifield R, et al., 2009, Pattern and Degree of Reverse Remodelling Following Extended Septal Myectomy for Hypertrophic Cardiomyopathy: An MRI Study, 82nd Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S794-S795, ISSN: 0009-7322
George RS, Yacoub MH, Webb C, et al., 2009, Contractile Reserve Assessment in DCM Patients Supported With Continuous Flow Left Ventricular Assist Device (LVAD), 82nd Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S726-S727, ISSN: 0009-7322
Siedlecka U, Gandhi A, Navaratnarajah M, et al., 2009, The Effects of SN-6, a Novel Sodium-Calcium Exchange Inhibitor, on Contractility and Calcium Handling in Isolated Failing Rat Cardiomyocytes, 82nd Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S886-S886, ISSN: 0009-7322
George RS, Yacoub MH, Webb C, et al., 2009, The Extent of Myocardial Recovery as Assessed by the Response of Echocardiographic Parameters to Exercise in Patients With Heartmate I and Heartmate II Left Ventricular Assist Devices (LVADs), 82nd Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S798-S798, ISSN: 0009-7322
Din S, Sarathchandra P, Yacoub MH, et al., 2009, Interaction between bone morphogenetic proteins and endothelin-1 in human pulmonary artery smooth muscle, VASCULAR PHARMACOLOGY, Vol: 51, Pages: 344-349, ISSN: 1537-1891
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- Citations: 9
El-Hamamsy I, Zaki M, Stevens LM, et al., 2009, Rate of Progression and Functional Significance of Aortic Root Calcification After Homograft Versus Freestyle Aortic Root Replacement, CIRCULATION, Vol: 120, Pages: S269-S275, ISSN: 0009-7322
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- Citations: 20
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