Imperial College London
Alternate

Dr Nik Ding

Faculty of Medicine, Department of Surgery & Cancer

Honorary Clinical Lecturer
 
 
 
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n.ding

 
 
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Location

 

Northwick ParkNorthwick Park and St Marks Site

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Summary

 

Publications

Citation

BibTex format

@article{Misra:2022:10.2147/CEG.S371965,
author = {Misra, R and Sarafian, M and Pechlivanis, A and Ding, N and Miguens-Blanco, J and McDonald, J and Holmes, E and Marchesi, J and Arebi, N},
doi = {10.2147/CEG.S371965},
journal = {Clinical and Experimental Gastroenterology},
pages = {199--212},
title = {Ethnicity associated microbial and metabonomic profiling in newly diagnosed ulcerative colitis},
url = {http://dx.doi.org/10.2147/CEG.S371965},
volume = {15},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Introduction:Ulcerative colitis (UC) differs across geography and ethnic groups. Gut microbial diversity plays a pivotal role in disease pathogenesis and differs across ethnic groups. The functional diversity in microbial-driven metabolites may have a pathophysiologic role and offer new therapeutic avenues.Methods:Demographics and clinical data were recorded from newly diagnosed UC patients. Blood, urine and faecal samples were collected at three time points over one year. Bacterial content was analysed by 16S rRNA sequencing. Bile acid profiles and polar molecules in three biofluids were measured using liquid-chromatography mass spectrometry (HILIC) and nuclear magnetic resonance spectroscopy.Results:We studied 42 patients with a new diagnosis of UC (27 South Asians; 15 Caucasians) with 261 biosamples. There were significant differences in relative abundance of bacteria at the phylum, genus and species level. Relative concentrations of urinary metabolites in South Asians were significantly lower for hippurate (positive correlation for Ruminococcus) and 4-cresol sulfate (Clostridia) (p<0.001) with higher concentrations of lactate (negative correlation for Bifidobacteriaceae). Faecal conjugated and primary conjugated bile acids concentrations were significantly higher in South Asians (p=0.02 and p=0.03 respectively). Results were unaffected by diet, phenotype, disease severity and ongoing therapy. Comparison of time points at diagnosis and at 1 year did not reveal changes in microbial and metabolic profile.Conclusion:Ethnic-related microbial metabolite associations were observed in South Asians with UC. This suggests a predisposition to UC may be influenced by environmental factors reflected in a distinct gene-environment interaction. The variations may serve as markers to identify risk factors for UC and modified to enhance therapeutic response.
AU  - Misra,R
AU  - Sarafian,M
AU  - Pechlivanis,A
AU  - Ding,N
AU  - Miguens-Blanco,J
AU  - McDonald,J
AU  - Holmes,E
AU  - Marchesi,J
AU  - Arebi,N
DO  - 10.2147/CEG.S371965
EP  - 212
PY  - 2022///
SN  - 1178-7023
SP  - 199
TI  - Ethnicity associated microbial and metabonomic profiling in newly diagnosed ulcerative colitis
T2  - Clinical and Experimental Gastroenterology
UR  - http://dx.doi.org/10.2147/CEG.S371965
UR  - http://hdl.handle.net/10044/1/101493
VL  - 15
ER  -
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