Publications
137 results found
Tassone D, Hartley I, Ding NS, 2023, Letter: Muscle thickness measurement using ultrasound-A step closer to the use of body composition analysis in the management of inflammatory bowel disease., Aliment Pharmacol Ther, Vol: 58, Pages: 729-730
Tassone D, Hartley I, Ding NS, 2023, Letter: Combatting sarcopenia to improve clinical outcomes in inflammatory bowel disease., Aliment Pharmacol Ther, Vol: 58, Pages: 376-377
Hartley I, Lee T, Ding NS, 2023, Editorial: improving the use of Montreal classification through a bidirectional approach., Aliment Pharmacol Ther, Vol: 58, Pages: 112-113
Yu N, Sriranganathan D, Walker GJ, et al., 2023, Prevalence of NUDT15 genetic variants and incidence of thiopurine-induced leukopenia in Inflammatory Bowel Disease: A systematic review and meta-analysis., J Crohns Colitis
BACKGROUND AND AIMS: Nudix hydrolase 15 (NUDT15) genetic variants confer an increased risk of thiopurine-induced leukopenia (TIL), however their global prevalence in Inflammatory Bowel Disease (IBD) patients is unknown. We aimed to evaluate the global prevalence of NUDT15 variants in IBD patients and incidence of TIL in these patients. METHODS: Six databases were searched from inception until July 2022. Studies reporting the frequency of any NUDT15 variant and/or frequency of leukopenia in adult IBD patients with these variants, were included. A random effects model was performed to estimate the pooled prevalence of variants, incidence of early (≤8 weeks) and late (>8 weeks) leukopenia, and relative risk of developing leukopenia. RESULTS: 20 studies comprising 5232 patients were included. The pooled prevalence of the *1/*3 c.415C>T C/T diplotype was 13% (95% CI: 10-18%), *3/*3 c.415C>T T/T diplotype was 2% (95% CI: 1-2%), *1/*5 c.52G>A G/A diplotype was 2% (95% CI: 1-3%) and *1/*6 c.36_37insGGAGTC ins/- diplotype was 7% (95% CI: 4-12%). The pooled prevalence of *1/*3 was high in Japanese (20%, 95% CI: 16-24%) and Chinese patients (18%, 95% CI: 12-27%). The incidence of early leukopenia was 20% (95% CI: 16-26%) in *1/*3 patients, 99% (95% CI: 7-100%) in *3/*3 patients and 49% (95% CI: 29-69%) in *1/*6 patients. The incidence of late leukopenia was 36% (95% CI: 26-49%) in *1/*3 patients. CONCLUSIONS: NUDT15 variants are common and strongly predict TIL in IBD patients. Pre-treatment NUDT15 genotyping should be considered particularly in Asian populations to guide thiopurine dosing and prevent myelotoxicity.
Tassone D, Gilmore R, Lee T, et al., 2023, Letter: diagnostic delay in inflammatory bowel disease., Aliment Pharmacol Ther, Vol: 57, Pages: 1203-1204
Gilmore R, Tassone D, Ding NS, 2023, Letter: tofacitinib in the real world - do clinical trial data stand up?, Aliment Pharmacol Ther, Vol: 57, Pages: 745-746
Noor NM, Sousa P, Bettenworth D, et al., 2023, ECCO Topical Review on Biological Treatment Cycles in Crohn's Disease, JOURNAL OF CROHNS & COLITIS, ISSN: 1873-9946
Ding NS, Tassone D, Al Bakir I, et al., 2022, Systematic review: the impact and importance of body composition in inflammatory bowel disease, Journal of Crohns & Colitis, ISSN: 1873-9946
Background and AimsAlterations in body composition are common in inflammatory bowel disease [IBD] and have been associated with differences in patient outcomes. We sought to consolidate knowledge on the impact and importance of body composition in IBD.MethodsWe performed a systematic search of MEDLINE, EMBASE and conference proceedings by combining two key research themes: inflammatory bowel disease and body composition.ResultsFifty-five studies were included in this review. Thirty-one focused on the impact of IBD on body composition with a total of 2279 patients with a mean age 38.4 years. Of these, 1071 [47%] were male. In total, 1470 [64.5%] patients had Crohn’s disease and 809 [35.5%] had ulcerative colitis. Notably, fat mass and fat-free mass were reduced, and higher rates of sarcopaenia were observed in those with active IBD compared with those in clinical remission and healthy controls. Twenty-four additional studies focused on the impact of derangements in body composition on IBD outcomes. Alterations in body composition in IBD are associated with poorer prognoses including higher rates of surgical intervention, post-operative complications and reduced muscle strength. In addition, higher rates of early treatment failure and primary non-response are seen in patients with myopaenia.ConclusionsPatients with IBD have alterations in body composition parameters in active disease and clinical remission. The impacts of body composition on disease outcome and therapy are broad and require further investigation. The augmentation of body composition parameters in the clinical setting has the potential to improve IBD outcomes in the future.
Tassone D, Singh S, Sheng Ding N, 2021, Editorial: impact of body mass index on clinical outcomes in patients with ulcerative colitis treated with tofacitinib, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Vol: 54, Pages: 206-207, ISSN: 0269-2813
Mattoo VY, Basnayake C, Connell WR, et al., 2021, Systematic review: efficacy of escalated maintenance anti-tumour necrosis factor therapy in Crohn's disease, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Vol: 54, Pages: 249-266, ISSN: 0269-2813
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- Citations: 5
Tambakis G, Lee T, Shah R, et al., 2021, Low failure to attend rates and increased clinic capacity with Telehealth: A highly effective outpatient model that should continue beyond the COVID-19 pandemic, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol: 36, Pages: 1136-1137, ISSN: 0815-9319
Lee T, Kamm MA, Bell S, et al., 2020, Long-term outcomes of perianal fistulizing Crohn's disease in the biologic era, JGH OPEN, Vol: 5, Pages: 235-241, ISSN: 2397-9070
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- Citations: 1
De Gregorio M, Lee T, Krishnaprasad K, et al., 2020, Higher anti-tumor necrosis factor-alpha drug levels are associated with improved radiological outcomes in patients with perianal fistulizing Crohn's disease: A retrospective multicenter study, Publisher: WILEY, Pages: 133-133, ISSN: 0815-9319
Mattoo V, Basnayake C, Connell W, et al., 2020, Escalated anti-tumor necrosis factor agent dosing in inflammatory bowel disease is associated with higher drug levels and a reduction in fecal calprotectin level for infliximab but not adalimumab, Publisher: WILEY, Pages: 140-140, ISSN: 0815-9319
Chan W, Kariyawasam VC, Kim S, et al., 2020, Gastroenterologists' preference and risk perception on the use of immunomodulators and biological therapies in elderly patients with ulcerative colitis: an international survey, EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, Vol: 32, Pages: 976-983, ISSN: 0954-691X
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- Citations: 7
Ding NS, McDonald JAK, Perdones-Montero A, et al., 2020, Metabonomics and the Gut Microbiome Associated With Primary Response to Anti-TNF Therapy in Crohn's Disease, JOURNAL OF CROHNS & COLITIS, Vol: 14, Pages: 1090-1102, ISSN: 1873-9946
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- Citations: 35
Dragoni G, Ding N, Gecse KB, et al., 2020, The prevention and management of Crohn's disease postoperative recurrence: results from the Y-ECCO/ClinCom 2019 Survey, EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, Vol: 32, Pages: 1062-1066, ISSN: 0954-691X
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- Citations: 4
Cordes F, Foell D, Ding JN, et al., 2020, Differential regulation of JAK/STAT-signaling in patients with ulcerative colitis and Crohn's disease, WORLD JOURNAL OF GASTROENTEROLOGY, Vol: 26, Pages: 4055-4075, ISSN: 1007-9327
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- Citations: 19
Ding NS, An P, Dong W, et al., 2020, reply, LANCET GASTROENTEROLOGY & HEPATOLOGY, Vol: 5, Pages: 640-641
Adegbola S, Sarafian M, Sahnan K, et al., 2020, MetabonomicProfiling Distinguishes Crohn's Perianal Fistulas and Idiopathic Idiopathic (Cryptoglandular) Perianal Fistulas - Possible Clues to Underlying Pathogenesis?, International Surgical Conference of the Association-of-Surgeons-in-Training, Publisher: WILEY, Pages: 17-17, ISSN: 0007-1323
An P, Ji M, Ren H, et al., 2020, Prevention of COVID-19 in patients with inflammatory bowel disease in Wuhan, China, LANCET GASTROENTEROLOGY & HEPATOLOGY, Vol: 5, Pages: 525-527
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- Citations: 63
Hui S, Krishna A, Ding NS, et al., 2020, Vedolizumab for induction and maintenance of remission in Crohn’s disease, Cochrane Database of Systematic Reviews, Vol: 2020
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. The primary objective of this systematic review of the literature is to assess the efficacy and safety of vedolizumab in the induction and maintenance of remission in Crohn's disease.
Lee T, Gilbert L, van Langenberg DR, et al., 2020, HIGHER ANTI-TNF alpha TROUGH LEVELS ARE ASSOCIATED WITH INCREASED RADIOLOGICAL RESPONSE IN PERIANAL FISTULISING CROHN'S DISEASE: A MULTI-CENTRE STUDY, Crohn's and Colitis Congress, Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: S1038-S1038, ISSN: 0016-5085
Adegbola S, Sarafian M, Sahnan K, et al., 2020, Metabonomic profiling distinguishes Crohn's perianal fistulas and idiopathic idiopathic (cryptoglandular) perianal fistulas: possible clues to underlying pathogenesis?, Publisher: OXFORD UNIV PRESS, Pages: S174-S174, ISSN: 1873-9946
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- Citations: 1
Wann S, Norris R, Williams R, et al., 2020, Endoscopic and histological activity is associated with non-response to biologic therapy in ulcerative colitis, Publisher: OXFORD UNIV PRESS, Pages: S376-S376, ISSN: 1873-9946
Lee T, Gilbert L, Srinivasan A, et al., 2020, Higher anti-TNF alpha trough levels are not associated with increased radiological response in perianal fistulising Crohn's disease: A multicentre study, Publisher: OXFORD UNIV PRESS, Pages: S449-S449, ISSN: 1873-9946
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- Citations: 1
Tassone D, Ding N, 2020, A review of adverse events associated with immunosuppressive treatments in inflammatory bowel disease patients, Publisher: OXFORD UNIV PRESS, Pages: S453-S453, ISSN: 1873-9946
Ferguson A, Ding N, Connell W, et al., 2020, Validation of the 'IBD Disk' in clinical practice, Publisher: OXFORD UNIV PRESS, Pages: S472-S472, ISSN: 1873-9946
Lee T, Yong E, Ding NS, 2019, Radiological outcomes in perianal fistulizing Crohn's disease: A systematic review and meta-analysis, JGH OPEN, Vol: 4, Pages: 340-344, ISSN: 2397-9070
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- Citations: 12
Bokemeyer A, Tepasse PR, Quill L, et al., 2019, Quantitative Phase Imaging Using Digital Holographic Microscopy Reliably Assesses Morphology and Reflects Elastic Properties of Fibrotic Intestinal Tissue, SCIENTIFIC REPORTS, Vol: 9, ISSN: 2045-2322
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- Citations: 13
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