Imperial College London
Portrait Picture

Professor Neil Fairweather

Faculty of Natural Sciences, Department of Life Sciences

Emeritus Professor
 
 
 
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Contact

 

+44 (0)20 7594 5247n.fairweather

 
 
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Location

 

1.44Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dang:2012:10.1016/j.bmc.2011.06.042,
author = {Dang, THT and Fagan, RP and Fairweather, NF and Tate, EW},
doi = {10.1016/j.bmc.2011.06.042},
journal = {Bioorganic & Medicinal Chemistry},
pages = {614--621},
title = {Novel inhibitors of surface layer processing in Clostridium difficile},
url = {http://dx.doi.org/10.1016/j.bmc.2011.06.042},
volume = {20},
year = {2012}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Clostridium difficile, a leading cause of hospital-acquired bacterial infection, is coated in a dense surface layer (S-layer) that is thought to provide both physicochemical protection and a scaffold for host-pathogen interactions. The key structural components of the S-layer are two proteins derived from a polypeptide precursor, SlpA, via proteolytic cleavage by the protease Cwp84. Here, we report the design, synthesis and in vivo characterization of a panel of protease inhibitors and activity-based probes (ABPs) designed to target S-layer processing in live C. difficile cells. Inhibitors based on substrate-mimetic peptides bearing a C-terminal Michael acceptor warhead were found to be promising candidates for further development.
AU  - Dang,THT
AU  - Fagan,RP
AU  - Fairweather,NF
AU  - Tate,EW
DO  - 10.1016/j.bmc.2011.06.042
EP  - 621
PY  - 2012///
SN  - 1464-3391
SP  - 614
TI  - Novel inhibitors of surface layer processing in Clostridium difficile
T2  - Bioorganic & Medicinal Chemistry
UR  - http://dx.doi.org/10.1016/j.bmc.2011.06.042
UR  - http://hdl.handle.net/10044/1/26863
VL  - 20
ER  -
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