Imperial College London
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ProfessorNickHopkinson

Faculty of Medicine, National Heart & Lung Institute

Professor of Respiratory Medicine
 
 
 
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n.hopkinson

 
 
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Location

 

Muscle LabSouth BlockRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Brakema:2019:10.1186/s12931-019-1255-z,
author = {Brakema, EA and Tabyshova, A and van, der Kleij RMJJ and Sooronbaev, T and Lionis, C and Anastasaki, M and An, PL and Nguyen, LT and Kirenga, B and Walusimbi, S and Postma, MJ and Chavannes, NH and van, Boven JFM},
doi = {10.1186/s12931-019-1255-z},
journal = {Respiratory Research},
pages = {1--10},
title = {The socioeconomic burden of chronic lung disease in low-resource settings across the globe – an observational FRESH AIR study},
url = {http://dx.doi.org/10.1186/s12931-019-1255-z},
volume = {20},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundLow-resource settings are disproportionally burdened by chronic lung disease due to early childhood disadvantages and indoor/outdoor air pollution. However, data on the socioeconomic impact of respiratory diseases in these settings are largely lacking. Therefore, we aimed to estimate the chronic lung disease-related socioeconomic burden in diverse low-resource settings across the globe. To inform governmental and health policy, we focused on work productivity and activity impairment and its modifiable clinical and environmental risk factors.MethodsWe performed a cross-sectional, observational FRESH AIR study in Uganda, Vietnam, Kyrgyzstan, and Greece. We assessed the chronic lung disease-related socioeconomic burden using validated questionnaires among spirometry-diagnosed COPD and/or asthma patients (total N = 1040). Predictors for a higher burden were studied using multivariable linear regression models including demographics (e.g. age, gender), health parameters (breathlessness, comorbidities), and risk factors for chronic lung disease (smoking, solid fuel use). We applied identical models per country, which we subsequently meta-analyzed.ResultsEmployed patients reported a median [IQR] overall work impairment due to chronic lung disease of 30% [1.8–51.7] and decreased productivity (presenteeism) of 20.0% [0.0–40.0]. Remarkably, work time missed (absenteeism) was 0.0% [0.0–16.7]. The total population reported 40.0% [20.0–60.0] impairment in daily activities. Breathlessness severity (MRC-scale) (B = 8.92, 95%CI = 7.47–10.36), smoking (B = 5.97, 95%CI = 1.73–10.22), and solid fuel use (B = 3.94, 95%CI = 0.56–7.31) were potentially modifiable risk factors for impairment.ConclusionsIn low-resource settings, chronic lung disease-related absenteeism is relatively low compared to the substantial presenteeism and activity im
AU  - Brakema,EA
AU  - Tabyshova,A
AU  - van,der Kleij RMJJ
AU  - Sooronbaev,T
AU  - Lionis,C
AU  - Anastasaki,M
AU  - An,PL
AU  - Nguyen,LT
AU  - Kirenga,B
AU  - Walusimbi,S
AU  - Postma,MJ
AU  - Chavannes,NH
AU  - van,Boven JFM
DO  - 10.1186/s12931-019-1255-z
EP  - 10
PY  - 2019///
SN  - 1465-9921
SP  - 1
TI  - The socioeconomic burden of chronic lung disease in low-resource settings across the globe – an observational FRESH AIR study
T2  - Respiratory Research
UR  - http://dx.doi.org/10.1186/s12931-019-1255-z
UR  - https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-019-1255-z
UR  - http://hdl.handle.net/10044/1/75781
VL  - 20
ER  -
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