Imperial College London
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PROFESSOR NICHOLAS LONG

Faculty of Natural Sciences, Department of Chemistry

Sir Edward Frankland BP Chair -Inorganic Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 5781n.long Website CV

 
 
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Location

 

501jMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gallo:2014:10.1002/anie.201405442,
author = {Gallo, J and Kamaly, N and Lavdas, I and Stevens, E and Nguyen, Q and Wylezinska-Arridge, M and Aboagye, EO and Long, NJ},
doi = {10.1002/anie.201405442},
journal = {Angewandte Chemie International Edition},
pages = {9550--9554},
title = {CXCR4-targeted and MMP-responsive iron oxide nanoparticles for enhanced magnetic resonance imaging},
url = {http://dx.doi.org/10.1002/anie.201405442},
volume = {53},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - MRI offers high spatial resolution with excellent tissue penetration but it has limited sensitivity and the commonly administered contrast agents lack specificity. In this study, two sets of iron oxide nanoparticles (IONPs) were synthesized that were designed to selectively undergo copper-free click conjugation upon sensing of matrix metalloproteinase (MMP) enzymes, thereby leading to a self-assembled superparamagnetic nanocluster network with T2 signal enhancement properties. For this purpose, IONPs with bioorthogonal azide and alkyne surfaces masked by polyethylene glycol (PEG) layers tethered to CXCR4-targeted peptide ligands were synthesized and characterized. The IONPs were tested invitro and T2 signal enhancements of around 160 % were measured when the IONPs were incubated with cells expressing MMP2/9 and CXCR4. Simultaneous systemic administration of the bioorthogonal IONPs in tumor-bearing mice demonstrated the signal-enhancing ability of these ‘smart’ self-assembling nanomaterials.
AU  - Gallo,J
AU  - Kamaly,N
AU  - Lavdas,I
AU  - Stevens,E
AU  - Nguyen,Q
AU  - Wylezinska-Arridge,M
AU  - Aboagye,EO
AU  - Long,NJ
DO  - 10.1002/anie.201405442
EP  - 9554
PY  - 2014///
SN  - 1521-3773
SP  - 9550
TI  - CXCR4-targeted and MMP-responsive iron oxide nanoparticles for enhanced magnetic resonance imaging
T2  - Angewandte Chemie International Edition
UR  - http://dx.doi.org/10.1002/anie.201405442
UR  - https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201405442
UR  - http://hdl.handle.net/10044/1/26353
VL  - 53
ER  -
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