Imperial College London
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ProfessorNickOliver

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Wynn Chair in Human Metabolism (Clinical)
 
 
 
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Contact

 

+44 (0)20 7594 1796nick.oliver

 
 
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Location

 

7S7aCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hudson:2023:10.1016/S2666-7568(23)00169-1,
author = {Hudson, J and Cruickshank, M and Quinton, R and Aucott, L and Wu, F and Grossmann, M and Bhasin, S and Snyder, PJ and Ellenberg, SS and Travison, TG and Brock, GB and Gianatti, EJ and van, der Schouw YT and Emmelot-Vonk, MH and Giltay, EJ and Hackett, G and Ramachandran, S and Svartberg, J and Hildreth, KL and Antonic, KG and Tenover, JL and Tan, HM and Ho, Chee Kong C and Tan, WS and Marks, LS and Ross, RJ and Schwartz, RS and Manson, P and Roberts, SA and Skovsager, Andersen M and Velling, Magnussen L and Aceves-Martins, M and Gillies, K and Hernández, R and Oliver, N and Dhillo, WS and Bhattacharya, S and Brazzelli, M and Jayasena, CN},
doi = {10.1016/S2666-7568(23)00169-1},
journal = {Lancet Healthy Longev},
pages = {e561--e572},
title = {Symptomatic benefits of testosterone treatment in patient subgroups: a systematic review, individual participant data meta-analysis, and aggregate data meta-analysis.},
url = {http://dx.doi.org/10.1016/S2666-7568(23)00169-1},
volume = {4},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Testosterone replacement therapy is known to improve sexual function in men younger than 40 years with pathological hypogonadism. However, the extent to which testosterone alleviates sexual dysfunction in older men and men with obesity is unclear, despite the fact that testosterone is being increasingly prescribed to these patient populations. We aimed to evaluate whether subgroups of men with low testosterone derive any symptomatic benefit from testosterone treatment. METHODS: We did a systematic review and meta-analysis to evaluate characteristics associated with symptomatic benefit of testosterone treatment versus placebo in men aged 18 years and older with a baseline serum total testosterone concentration of less than 12 nmol/L. We searched major electronic databases (MEDLINE, Embase, Science Citation Index, and the Cochrane Central Register of Controlled Trials) and clinical trial registries for reports published in English between Jan 1, 1992, and Aug 27, 2018. Anonymised individual participant data were requested from the investigators of all identified trials. Primary (cardiovascular) outcomes from this analysis have been published previously. In this report, we present the secondary outcomes of sexual function, quality of life, and psychological outcomes at 12 months. We did a one-stage individual participant data meta-analysis with a random-effects linear regression model, and a two-stage meta-analysis integrating individual participant data with aggregated data from studies that did not provide individual participant data. This study is registered with PROSPERO, CRD42018111005. FINDINGS: 9871 citations were identified through database searches. After exclusion of duplicates and publications not meeting inclusion criteria, 225 full texts were assessed for inclusion, of which 109 publications reporting 35 primary studies (with a total 5601 participants) were included. Of these, 17 trials provided individual participant data (3431 participants; m
AU  - Hudson,J
AU  - Cruickshank,M
AU  - Quinton,R
AU  - Aucott,L
AU  - Wu,F
AU  - Grossmann,M
AU  - Bhasin,S
AU  - Snyder,PJ
AU  - Ellenberg,SS
AU  - Travison,TG
AU  - Brock,GB
AU  - Gianatti,EJ
AU  - van,der Schouw YT
AU  - Emmelot-Vonk,MH
AU  - Giltay,EJ
AU  - Hackett,G
AU  - Ramachandran,S
AU  - Svartberg,J
AU  - Hildreth,KL
AU  - Antonic,KG
AU  - Tenover,JL
AU  - Tan,HM
AU  - Ho,Chee Kong C
AU  - Tan,WS
AU  - Marks,LS
AU  - Ross,RJ
AU  - Schwartz,RS
AU  - Manson,P
AU  - Roberts,SA
AU  - Skovsager,Andersen M
AU  - Velling,Magnussen L
AU  - Aceves-Martins,M
AU  - Gillies,K
AU  - Hernández,R
AU  - Oliver,N
AU  - Dhillo,WS
AU  - Bhattacharya,S
AU  - Brazzelli,M
AU  - Jayasena,CN
DO  - 10.1016/S2666-7568(23)00169-1
EP  - 572
PY  - 2023///
SP  - 561
TI  - Symptomatic benefits of testosterone treatment in patient subgroups: a systematic review, individual participant data meta-analysis, and aggregate data meta-analysis.
T2  - Lancet Healthy Longev
UR  - http://dx.doi.org/10.1016/S2666-7568(23)00169-1
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37804846
VL  - 4
ER  -
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