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@article{Agier:2019:10.1016/S2542-5196(19)30010-5,
author = {Agier, L and Basagaña, X and Maitre, L and Granum, B and Bird, PK and Casas, M and Oftedal, B and Wright, J and Andrusaityte, S and de, Castro M and Cequier, E and Chatzi, L and Donaire-Gonzalez, D and Grazuleviciene, R and Haug, LS and Sakhi, AK and Leventakou, V and McEachan, R and Nieuwenhuijsen, M and Petraviciene, I and Robinson, O and Roumeliotaki, T and Sunyer, J and Tamayo-Uria, I and Thomsen, C and Urquiza, J and Valentin, A and Slama, R and Vrijheid, M and Siroux, V},
doi = {10.1016/S2542-5196(19)30010-5},
journal = {Lancet Planetary Health},
pages = {e81--e92},
title = {Early life exposome and lung function in children in Europe: An analysis of data  from the longitudinal, population-based HELIX cohort},
url = {http://dx.doi.org/10.1016/S2542-5196(19)30010-5},
volume = {3},
year = {2019}
}

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TY  - JOUR
AB  - BackgroundSeveral single-exposure studies have documented possible effects of environmental factors on lung function, but none has relied on an exposome approach. We aimed to evaluate the association between a broad range of prenatal and postnatal lifestyle and environmental exposures and lung function in children.MethodsIn this analysis, we used data from 1033 mother–child pairs from the European Human Early-Life Exposome (HELIX) cohort (consisting of six existing longitudinal birth cohorts in France, Greece, Lithuania, Norway, Spain, and the UK of children born between 2003 and 2009) for whom a valid spirometry test was recorded for the child. 85 prenatal and 125 postnatal exposures relating to outdoor, indoor, chemical, and lifestyle factors were assessed, and lung function was measured by spirometry in children at age 6–12 years. Two agnostic linear regression methods, a deletion-substitution-addition (DSA) algorithm considering all exposures simultaneously, and an exposome-wide association study (ExWAS) considering exposures independently, were applied to test the association with forced expiratory volume in 1 s percent predicted values (FEV1%). We tested for two-way interaction between exposures and corrected for confounding by co-exposures.FindingsIn the 1033 children (median age 8·1 years, IQR 6·5–9·0), mean FEV1% was 98·8% (SD 13·2). In the ExWAS, prenatal perfluorononanoate (p=0·034) and perfluorooctanoate (p=0·030) exposures were associated with lower FEV1%, and inverse distance to nearest road during pregnancy (p=0·030) was associated with higher FEV1%. Nine postnatal exposures were associated with lower FEV1%: copper (p=0·041), ethyl-paraben (p=0·029), five phthalate metabolites (mono-2-ethyl 5-carboxypentyl phthalate [p=0·016], mono-2-ethyl-5-hydroxyhexyl phthalate [p=0·023], mono-2-ethyl-5-oxohexyl phthalate [p=0·0085], mono-4-methyl-7-oxooctyl
AU  - Agier,L
AU  - Basagaña,X
AU  - Maitre,L
AU  - Granum,B
AU  - Bird,PK
AU  - Casas,M
AU  - Oftedal,B
AU  - Wright,J
AU  - Andrusaityte,S
AU  - de,Castro M
AU  - Cequier,E
AU  - Chatzi,L
AU  - Donaire-Gonzalez,D
AU  - Grazuleviciene,R
AU  - Haug,LS
AU  - Sakhi,AK
AU  - Leventakou,V
AU  - McEachan,R
AU  - Nieuwenhuijsen,M
AU  - Petraviciene,I
AU  - Robinson,O
AU  - Roumeliotaki,T
AU  - Sunyer,J
AU  - Tamayo-Uria,I
AU  - Thomsen,C
AU  - Urquiza,J
AU  - Valentin,A
AU  - Slama,R
AU  - Vrijheid,M
AU  - Siroux,V
DO  - 10.1016/S2542-5196(19)30010-5
EP  - 92
PY  - 2019///
SN  - 2542-5196
SP  - 81
TI  - Early life exposome and lung function in children in Europe: An analysis of data  from the longitudinal, population-based HELIX cohort
T2  - Lancet Planetary Health
UR  - http://dx.doi.org/10.1016/S2542-5196(19)30010-5
UR  - http://hdl.handle.net/10044/1/66942
VL  - 3
ER  -

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